Abstract: An FXR small molecule agonist and a preparation method therefor and a use thereof, having a structure as shown in formula (I). The compound represented by formula (I) has FXR agonistic activity and is capable of preparing drugs for treatment of FXR-related diseases.

Abstract: The present invention discloses a disaster prevention, early warning and production decision support method and system for a power distribution network, and relates to the technical field of the power distribution network. Various data is fused, a maximum wind load, a lightning trip-out rate, a maximum carrying capacity at a highest operation temperature and an average failure frequency and time under an environmental factor are calculated, and a power outage risk is evaluated and classified; and after an emergency, a power grid topology is analyzed, and a device outage probability is calculated to obtain a load power outage probability and risk and provide disaster early warning, monitoring and rush repair decision support.

Abstract: A polypyrrole-graphene/polyurethane antifouling coating as well as a preparation method and an application thereof are provided. The polypyrrole-graphene/polyurethane antifouling coating includes component A and component B, wherein the component A mainly includes the following raw materials in parts by weight: 500 parts of group-hydrolyzable polyurethane prepolymer, 25-50 parts of bentonite, 25-50 parts of titanium dioxide, 60-120 parts of zinc oxide, 15-30 parts of talcum powder, and 15-30 parts of polypyrrole-graphene nanofiller; and the component B mainly includes the following raw materials in parts by weight: 5-7 parts of leveling agent, 5-7 parts of defoamer, 6-15 parts of chain extender, 10-25 parts of silane coupling agent, and 1-2 parts of catalyst. The two-component polyurethane coating of the present invention has relatively good adhesion, collision resistance and cracking resistance, and the antifouling property and the antifouling durability can be improved.

Abstract: The present disclosure provides an array substrate including a driving circuit board, and a first electrode layer, an insulating layer, and an anode structure sequentially stacked thereon. The anode structure includes a reflective layer, an intermediate dielectric layer, and a transparent conductive layer sequentially provided in a direction away from the driving circuit board. The array substrate has first, second, and third pixel regions. The anode structure includes first, second, and third anode structures. The first electrode layer includes first, second and third sub-portions. The first, second and third anode structures are coupled with the first, second and third sub-portions through first, second and third via holes in the insulating layer, respectively. A surface of the insulating layer in contact with the first, second and third anode structures is flush; and a thickness of the intermediate dielectric layer in the second, first and third anode structures increases sequentially.

Abstract: A port determining method and apparatus, a terminal, and a readable storage medium. The port determining method according to embodiments of this application includes: determining, by a terminal, a scheme used for uplink transmission; and determining a demodulation reference signal (DMRS) port for the uplink transmission according to the scheme.

Abstract: The present application discloses an information transmission method and apparatus, a terminal, and a readable storage medium. The information transmission method of embodiments of the present application includes: determining, by a terminal, a first PTRS port and a transmission layer or DMRS port corresponding to the first PTRS port according to a first TPMI field, where the first TPMI field is a TPMI field associated with a target object associated with uplink transmission of the terminal, and the first PTRS port is a PTRS port actually used by the terminal; and performing uplink transmission by using the first PTRS port and the transmission layer or DMRS port corresponding to the first PTRS port.

Abstract: A computer system obtains the image including one or more text areas, and generates a sequence of feature maps from the image based on a downsampling rate. Each feature map has a first dimension and a second dimension, and the feature maps include a first feature map and a second feature map. Each of the first and second dimensions of the first feature map has a respective size that is reduced to that of a respective dimension of the second feature map by the downsampling rate. The second feature map is upsampled by an upsampling rate using a local context-aware upsampling network. The upsampled second feature map is aggregated with the first feature map to generate an aggregated first feature map. The one or more text areas are identified in the image based on the aggregated first feature map.

Abstract: One example method includes receiving, by a machine learning (“ML”) model of a conference client application, audio signals received from a microphone of a client device, the client device connected to a virtual meeting via the conference client application, the virtual meeting hosted by a virtual conference provider; determining, by the ML model, a plurality of candidate reactions associated with the audio signals, the ML comprising a plurality of convolutional neural network (“CNN”) layers and at least one fully connected layer; selecting a reaction from the plurality of candidate reactions; and transmitting the reaction to the virtual conference provider.

Abstract: This application is directed to audio purification. An audio purification method, a computer system and a non-transitory computer-readable medium are provided. The audio purification method includes: obtaining image data corresponding to a sequence of image frames that focus on lip movement of a person; obtaining audio data that is synchronous with the lip movement in the sequence of image frames; and modifying the audio data using the image data.

Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z—R15, Z-A-Z—R16, Z-A-Z—R17, Z-A-Z—R18 or Z-G-N(R8)R9 is released that is immobilized on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.

Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z—R15, Z-A-Z—R16, Z-A-Z—R17, Z-A-Z—R18 or Z-G-N(R8)R9 is released that is immobilized on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.

Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z—R15, Z-A-Z—R16, Z-A-Z—R17, Z-A-Z—R18 or Z-G-N(R8)R9 is released that is immobilised on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.

Abstract: The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanotube of a metal, boron nitride and/or carbon. The respective metal is capable of forming one of a covalent bond, a coordinative bond and a non-covalent interaction with a thio or a seleno group. The sample is contacted with a compound of one of general formulas (I)-(III) and (VII)-(IX). At least one beta-lactam moiety of the compound is cleaved by the beta-lactamase activity in the sample. As a result a cleavage moiety Z-A-Z, Z-A-Z-R15, Z-A-Z-R16, Z-A-Z-R17, Z-A-Z-R18 or Z-G-N(R8)R9 is released that is immobilised on the surface of the nanoparticulate tag by a covalent bond via a Z atom. The presence of beta-lactamase activity is determined based on the presence of the cleavage moiety immobilized onto the surface of the nanoparticulate tag.