Abstract: A peritoneal dialysis (“PD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; a manifold assembly including a rigid manifold having first and second chambers (110a, 110b), the rigid manifold configured and arranged to be abutted against the actuation surface for operation, a peristaltic pump tube (124gh) extending from the first chamber (110a) to the second chamber (110b) of the rigid manifold, a dialysis fluid container line (124b) extending from the first chamber (110a), and a branch line (124c) extending between the dialysis fluid container line (124b) and the second chamber (110b); and a control unit configured to cause the peristaltic pump actuator to actuate the peristaltic pump tube (124gh) to pump dialysis fluid from the branch line (124c) into the second chamber (110b) and from the second chamber (110b) into the first chamber (110a).

Abstract: A peritoneal dialysis (“PD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; at least one pair of capacitive sensing plates; a manifold assembly including a rigid manifold having at least one chamber, the rigid manifold configured and arranged to be abutted against the actuation surface for operation, wherein the at least one pair of capacitive sensing plates is positioned to be operable with the at least one chamber; a peristaltic pump tube; and a control unit configured to actuate the peristaltic pump actuator to pump an amount of dialysis fluid to the at least one chamber, receive a signal from the pair of capacitive sensing plates, count a number of revolutions of the peristaltic pump actuator, determine a current volume per revolution for the peristaltic pump actuator, and use the current volume per revolution for a subsequent operation of the peristaltic pump actuator.

Abstract: A peritoneal dialysis (“RD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; a manifold assembly including a rigid manifold having first and second chambers (110a, 110b), the rigid manifold configured and arranged to be abutted against the actuation surface for operation, a peristaltic pump tube (124gh) extending from the first chamber (110a) to the second chamber (110b) of the rigid manifold, a dialysis fluid container line (124b) extending from the first chamber (110a), and a branch line (124c) extending between the dialysis fluid container line (124b) and the second chamber (110b); and a control unit configured to cause the peristaltic pump actuator to actuate the peristaltic pump tube (124gh) to pump dialysis fluid from the branch line (124c) into the second chamber (100b) and from the second chamber (110b) into the first chamber (110a).

Abstract: A disposable set (100) includes a tube; and a sensing member (104) press-fittingly insertable into the tube, the sensing member including: a first end (106) having a first diameter and including at least one through hole (112) positioned along a perimeter of the first end; a second end (108) having a second diameter and including at least one through hole positioned along a perimeter of the second end, the first diameter and the second diameter being substantially equal to an interior diameter of the tube; and a middle portion (110) located between the first end and the second end having a diameter that is less than the first diameter, the middle portion including at least one SERS sensing element (114), wherein the through holes in the first and second ends enable fluid to pass through the sensing member.

Abstract: A disposable set (100) includes a tube; and a sensing member (104) press-fittingly insertable into the tube, the sensing member including: a first end (106) having a first diameter and including at least one through hole (112) positioned along a perimeter of the first end; a second end (108) having a second diameter and including at least one through hole positioned along a perimeter of the second end, the first diameter and the second diameter being substantially equal to an interior diameter of the tube; and a middle portion (110) located between the first end and the second end having a diameter that is less than the first diameter, the middle portion including at least one SERS sensing element (114), wherein the through holes in the first and second ends enable fluid to pass through the sensing member.

Abstract: Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodialysis and electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source, an ED/EDI unit. The carbon source, urease source, and/or the ED/EDI unit can be in the form of removable cartridges.

Abstract: Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodialysis and electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source, an ED/EDI unit. The carbon source, urease source, and/or the ED/EDI unit can be in the form of removable cartridges.

Abstract: Systems and methods for hemodialysis or peritoneal dialysis having integrated electrodialysis and electrodeionization capabilities are provided. In an embodiment, the dialysis system includes a carbon source, a urease source, an ED/EDI unit. The carbon source, urease source, and/or the ED/EDI unit can be in the form of removable cartridges.

Abstract: A medical fluid infusion system including: a fluid pathway for transporting a pulsatile flow of fluid; a dampening element in communication with the fluid pathway, the dampening element configured to actively dampen pressure fluctuations of the pulsatile flow to smoothen the pulsatile fluid flow, the dampening element operable in any orientation; and a fluid flow sensor disposed along the fluid pathway downstream of the dampening element to measure the flow rate of the smoothened fluid flow.

Abstract: Systems and methods for providing dialysis therapies are provided. In a general embodiment, the present disclosure provides an apparatus for dialysis treatment comprising first and second fluid flow pathways in a parallel arrangement. The first fluid flow pathway contains a first cation exchange resin, wherein greater than 90% of exchange sites of the first cation exchange resin are populated with hydrogen ions. The second fluid flow pathway contains a second cation exchange resin, wherein greater than 90% of exchange sites of the second cation exchange resin are populated with sodium ions. The apparatus can be used to maintain a constant and safe level of sodium in a constantly regenerated dialysis fluid over an extended period of time.

Abstract: A medical fluid infusion system including: a fluid pathway for transporting a pulsatile flow of fluid; a dampening element in communication with the fluid pathway, the dampening element configured to actively dampen pressure fluctuations of the pulsatile flow to smoothen the pulsatile fluid flow, the dampening element operable in any orientation; and a fluid flow sensor disposed along the fluid pathway downstream of the dampening element to measure the flow rate of the smoothened fluid flow.