Patents by Inventor Rongshi Li

Rongshi Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolomycins and methods of using the same
    Patent number: 10954192
    Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: March 23, 2021
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Kenneth Bayles, Rongshi Li, Yan Liu
  • PYRROLOMYCINS AND METHODS OF USING THE SAME
    Publication number: 20190330147
    Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 31, 2019
    Inventors: Kenneth Bayles, Rongshi Li, Yan Liu
  • Pyrrolomycins and methods of using the same
    Patent number: 10414725
    Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: September 17, 2019
    Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Kenneth Bayles, Rongshi Li, Yan Liu
  • Marinopyrrole derivatives and methods of making and using same
    Patent number: 10358454
    Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: July 23, 2019
    Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., CHONGQING ZEIN PHARMACEUTICAL CO., LTD
    Inventors: Rongshi Li, Said Sebti, Yan Liu, Yong Qin, Hao Song, Chunwei Cheng
  • MARINOPYRROLE DERIVATIVES AND METHODS OF MAKING AND USING SAME
    Publication number: 20180265522
    Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
    Type: Application
    Filed: January 12, 2018
    Publication date: September 20, 2018
    Inventors: Rongshi Li, Said Sebti, Yan Liu, Yong Qin, Hao Song, Chunwei Cheng
  • PYRROLOMYCINS AND METHODS OF USING THE SAME
    Publication number: 20180194725
    Abstract: Provided herein are pyrrolomycin derivatives, which can be used to modulate Mcl-1, inhibit proliferation of bacteria and pathogens, as well as to treat infectious diseases and cancers.
    Type: Application
    Filed: July 15, 2016
    Publication date: July 12, 2018
    Inventors: Kenneth Bayles, Rongshi Li, Yan Liu
  • Marinopyrrole derivatives and methods of making and using same
    Patent number: 9868747
    Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: January 16, 2018
    Assignees: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., CHONGQING ZEIN PHARMACEUTICAL CO., LTD
    Inventors: Rongshi Li, Said Sebti, Yan Liu, Yong Qin, Hao Song, Chunwei Cheng
  • Inhibitors of Rho associated protein kinases (ROCK) and methods of use
    Patent number: 9808447
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: November 7, 2017
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • Symmetrical marinopyrrole derivatives as potential antibiotic agents
    Patent number: 9700044
    Abstract: Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: July 11, 2017
    Assignees: H. Lee Moffitt Cancer Center and Research Institute, Inc., Chongqing Zein Pharmaceutical Co., Ltd.
    Inventors: Yong Qin, Chunwei Cheng, Hao Song, Rongshi Li, Yan Liu
  • INHIBITORS OF RHO ASSOCIATED PROTEIN KINASES (ROCK) AND METHODS OF USE
    Publication number: 20170049760
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Application
    Filed: August 8, 2016
    Publication date: February 23, 2017
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • MARINOPYRROLE DERIVATIVES AND METHODS OF MAKING AND USING SAME
    Publication number: 20170050981
    Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
    Type: Application
    Filed: February 18, 2015
    Publication date: February 23, 2017
    Inventors: Rongshi Li, Said Sebti, Yan Liu, Yong Qin, Hao Song, Chunwei Cheng
  • Inhibitors of rho associated protein kinases (ROCK) and methods of use
    Patent number: 9409868
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: August 9, 2016
    Assignee: H. Lee Moffin Cancer Center and Research Institute, Inc.
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • Marinopyrrole derivatives as anticancer agents
    Patent number: 9340501
    Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing cancer.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: May 17, 2016
    Assignee: H. Lee Moffitt Cancer Center and Research Institute, Inc.
    Inventors: Rongshi Li, Said M. Sebti, Yan Liu
  • SYMMETRICAL MARINOPYRROLE DERIVATIVES AS POTENTIAL ANTIBIOTIC AGENTS
    Publication number: 20150366197
    Abstract: Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.
    Type: Application
    Filed: January 22, 2014
    Publication date: December 24, 2015
    Inventors: Yong Qin, Chunwei Cheng, Hao Song, Rongshi Li, Yan Liu
  • MARINOPYRROLE DERIVATIVES AS ANTICANCER AGENTS
    Publication number: 20150080632
    Abstract: Marinopyrrole derivatives and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing cancer.
    Type: Application
    Filed: February 1, 2013
    Publication date: March 19, 2015
    Inventors: Rongshi Li, Said M. Sebti, Yan Liu
  • INHIBITORS OF RHO ASSOCIATED PROTEIN KINASES (ROCK) AND METHODS OF USE
    Publication number: 20140336440
    Abstract: Compounds and compositions having activity as inhibitors of Rho-associated proteinkinases (ROCKs), and methods of making and using the subject compounds are disclosed.
    Type: Application
    Filed: January 24, 2013
    Publication date: November 13, 2014
    Inventors: Ernst Schonbrunn, Rongshi Li, Said M. Sebti
  • Inhibitors of metazoan parasite proteases
    Patent number: 6194421
    Abstract: Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I A—X—B wherein A is a substituted or unsubstituted heteroaromatic ring system comprising one to three rings which binds to at least one of the S2, S1 and S1′ subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which binds to at least one of the S1′, S1 and S2 subsites; and X is —C═C—C(═O)—. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria and other infectious diseases.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: February 27, 2001
    Assignee: The Regents of the University of California
    Inventors: Fred E. Cohen, James H. McKerrow, George L. Kenyon, Zhe Li, Xiaowu Chen, Baoqing Gong, Rongshi Li
  • Inhibitors of metazoan parasite proteases
    Patent number: 5739170
    Abstract: Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula IA--X--Bwherein A is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which bind to at least one of the S2, S1 and S1' subsites; B is a substituted or unsubstituted homoaromatic ring system comprising one to three rings which bind to at least one of the S1', S1 and S2 subsites; and X is --C.dbd.C--C(.dbd.O)--. These compositions and methods have particular utility in the treatment of schistosomiasis, malaria, and other infectious diseases.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: April 14, 1998
    Assignee: The Regents of the University of California
    Inventors: Fred E. Cohen, James H. McKerrow, George L. Kenyon, Zhe Li, Xiaowu Chen, Baoqing Gong, Rongshi Li