Patents by Inventor Rongzhen SHI

Rongzhen SHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMORPH OF KRAS INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
    Publication number: 20250051333
    Abstract: Provided are a polymorph of a KRAS inhibitor, a preparation method therefor, and a use thereof. Specifically disclosed is a pharmaceutically acceptable salt of a compound 1 or a polymorph of the compound or pharmaceutically acceptable salt thereof, and further disclosed are a preparation method for the salt or polymorph and an application of the salt or polymorph in the treatment and/or prevention of KRAS G12C mutation-related diseases.
    Type: Application
    Filed: December 23, 2022
    Publication date: February 13, 2025
    Applicants: GENFLEET THERAPEUTICS (SHANGHAI) INC., ZHEJIANG GENFLEET THERAPEUTICS CO., LTD.
    Inventors: Fusheng ZHOU, Jinzhu ZHAO, Yudong CAO, Lun XIONG, Rongzhen SHI, Jiong LAN
  • Preparation of (?)-huperzine A
    Patent number: 9586904
    Abstract: The present invention relates to a method for preparing (?)-huperzine A. The method involves: allowing a mixture of (±)-huperzine A obtained from chemical synthesis and a chiral acid to form (±)-huperzine A chiral acid salt under suitable conditions; recrystallizing the chiral acid salt from an organic solvent and basifying with an alkali to obtain optically pure (?)-huperzine A. The method is convenient to operate and suitable for industrial production. The chemical purity and optical purity of (?)-huperzine A obtained by the method are each greater than 99.5%, satisfying the requirement for raw pharmaceutical purity in the pharmaceutical industry.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: March 7, 2017
    Assignee: ZHEJIANG WANBANG PHARMACEUTICAL PLC.
    Inventors: Shouming Zhao, Ping Chen, Shaoping Peng, Yinqiang Zhuang, Rongzhen Shi, Jinsheng Xie, Weihua Xie
  • PREPARATION OF (-)-HUPERZINE A
    Publication number: 20160159745
    Abstract: The present invention relates to a method for preparing (?)-huperzine A. The method involves: allowing a mixture of (±)-huperzine A obtained from chemical synthesis and a chiral acid to form (±)-huperzine A chiral acid salt under suitable conditions; recrystallizing the chiral acid salt from an organic solvent and basifying with an alkali to obtain optically pure (?)-huperzine A. The method is convenient to operate and suitable for industrial production. The chemical purity and optical purity of (?)-huperzine A obtained by the method are each greater than 99.5%, satisfying the requirement for raw pharmaceutical purity in the pharmaceutical industry.
    Type: Application
    Filed: June 17, 2014
    Publication date: June 9, 2016
    Inventors: Shouming ZHAO, Ping CHEN, Shaoping PENG, Yinqiang ZHUANG, Rongzhen SHI, Jinsheng XIE, Weihua XIE