Patents by Inventor Ronnie C. Mease

Ronnie C. Mease has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rigid bifunctional chelating agents
    Patent number: 6022522
    Abstract: Bicyclo[2.2.2]octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo[2.2.1]heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.
    Type: Grant
    Filed: March 23, 1998
    Date of Patent: February 8, 2000
    Assignee: Brookhaven Science Associates
    Inventors: Mark P. Sweet, Ronnie C. Mease, Suresh C. Srivastava
  • (Aminostyryl)pyridinium compounds for radiolabelling cell membranes
    Patent number: 5840859
    Abstract: A compound is provided of formula I: ##STR1## wherein n is 4-16, Det is an organic group comprising a radioisotope or capable of chelating a radioisotope, and Z.sup.- is one equivalent of a biologically acceptable anion, which compounds are useful to radiolabel cellular membranes, as of hematopoietic cells.
    Type: Grant
    Filed: June 27, 1996
    Date of Patent: November 24, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Carol Lambert, Ronnie C. Mease, John G. McAfee
  • Rigid bifunctional chelating agents
    Patent number: 5783169
    Abstract: Bicyclo?2.2.2! octane-2,3 diamine-N,N,N',N'-tetraacetic acids (BODTA) and bicyclo?2.2.1! heptane-2,3 diamine-N,N,N',N'-tetraacetic acid (BHDTA) are chelating agents useful in forming detectably labeled bioconjugate compounds for diagnostic and therapeutic purposes. New compounds and processes of forming BODTA and BHDTA are disclosed. Radioimmunoconjugates of the present invention show high and prolonged tumor uptake with low normal tissue uptakes.
    Type: Grant
    Filed: July 26, 1995
    Date of Patent: July 21, 1998
    Assignee: Brookhaven Science Associates LLC
    Inventors: Mark P. Sweet, Ronnie C. Mease, Suresh C. Srivastava
  • Macrocyclic polyaminocarboxylates for stable radiometal antibody conjugates for therapy, spect and pet imaging
    Patent number: 5639879
    Abstract: A simple method for the synthesis of 1,4,7, 10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7, 10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.
    Type: Grant
    Filed: February 2, 1995
    Date of Patent: June 17, 1997
    Assignee: Associated Universities, Inc.
    Inventors: Ronnie C. Mease, Leonard F. Mausner, Suresh C. Srivastava
  • Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
    Patent number: 5635157
    Abstract: Cyclohexyl chelating agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N, N, N', N'-tetra acetic acid.
    Type: Grant
    Filed: October 6, 1993
    Date of Patent: June 3, 1997
    Inventors: Ronnie C. Mease, Kathryn L. Kolsky, Leonard F. Mausner, Suresh C. Srivastava
  • Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging
    Patent number: 5428156
    Abstract: A simple method for the synthesis of 1,4,7,10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.
    Type: Grant
    Filed: April 2, 1993
    Date of Patent: June 27, 1995
    Assignee: Associated Universities, Inc.
    Inventors: Ronnie C. Mease, Leonard F. Mausner, Suresh C. Srivastava
  • Stable radiometal antibody immunoconjugates
    Patent number: 5334729
    Abstract: The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.
    Type: Grant
    Filed: November 4, 1991
    Date of Patent: August 2, 1994
    Assignee: Associated Universities, Inc.
    Inventors: Ronnie C. Mease, Suresh C. Srivastava, Jean-Francois Gestin
  • Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
    Patent number: 5292938
    Abstract: Cyclo agents useful in forming antibody-metal conjugates useful for diagnostic and therapeutic purposes. New compounds and processes of forming these compounds are disclosed including 4-haloacetamido-trans-1,2-diaminocyclohexyl polyaminocarboxylate and 4-isothiocyanato-trans-1,2-diamino cyclohexane-N,N,N',N'-tetra acetic acid.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: March 8, 1994
    Assignee: Associated Universities, Inc.
    Inventors: Ronnie C. Mease, Leonard F. Mausner, Suresh C. Srivastava
  • Cyclohexyl-triethylenetetraamine hexacetic acid
    Patent number: 5089663
    Abstract: The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.
    Type: Grant
    Filed: April 2, 1991
    Date of Patent: February 18, 1992
    Assignee: Associated Universities, Inc.
    Inventors: Ronnie C. Mease, Suresh C. Srivastava, Jean-Francois Gestin
  • Cyclohexyl EDTA monoanhydride
    Patent number: 5021571
    Abstract: The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the transforms of cyclohexyl DTPA and TTHA and derivatives of these cyclohexyl polyaminocarboxylate materials.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: June 4, 1991
    Assignee: Associated Universities, Inc.
    Inventors: Ronnie C. Mease, Suresh C. Srivastava