Abstract: Disclosed is a composition for intravaginal and/or for internal mucosal application, comprising an effective amount of a sulfated polysaccharide, one or more of a natural quaternary polymer, a quaternary molecular compound, a metalloproteinase inhibitor, one or more anti-inflammatory agent, an acid pH control buffering system or any combination thereof, and a pharmaceutically acceptable carrier. Further disclosed is a method of treating or alleviating vaginal infection, vaginal dryness, vaginal or vulvo vaginal atrophy, vaginal itching, dyspareunia, vaginal or vulvar pain, vaginal or perivaginal inflammation or for promoting vaginal or wound healing, vaginal atrophy/dryness caused by radiotherapy, chemotherapy and/or hormonal treatment and decreased vaginal boundary lubrication or a disease or condition associated therewith or of improving vaginal boundary lubrication.

Abstract: A method for noninvasive analysis of subcutaneous tissue includes irradiating a surface of the tissue with short wave infrared (SWIR) radiation in a first spectral band that is strongly absorbed by water, and with SWIR radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical. An intensity of the radiation in each of the spectral bands that emerges from the tissue is measured. A relative absorption by the tissue of radiation in one of spectral bands relative to absorption by the tissue of radiation in the other of the spectral bands is calculated. A state of the tissue is determined in accordance with the calculated relative absorption.

Abstract: Systems, devices and methods for noninvasive analysis of tissue, by irradiating a surface of the tissue with infrared radiation such that an interaction of the radiation with a component of the tissue other than water in two spectral bands is substantially identical, measuring an intensity of the radiation that emerges from the tissue in each of the spectral bands, determining change in at least one of shape and intensity of signals received by the at least one radiation detector, calculating a relative absorption by the tissue of radiation in one of the first and second spectral bands relative to absorption by the tissue of radiation in the other of the first and second spectral bands, and determining concentration of a predetermined substance, in accordance with the calculated relative absorption and in accordance with determined change in the received signal.

Abstract: A method for noninvasive analysis of subcutaneous tissue includes irradiating a surface of the tissue with short wave infrared (SWIR) radiation in a first spectral band that is strongly absorbed by water, and with SWIR radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical. An intensity of the radiation in each of the spectral bands that emerges from the tissue is measured. A relative absorption by the tissue of radiation in one of spectral bands relative to absorption by the tissue of radiation in the other of the spectral bands is calculated. A state of the tissue is determined in accordance with the calculated relative absorption.

Abstract: The present invention relates to a composition for intravaginal and/or for internal mucosal application, comprising an effective amount of a sulfated polysaccharide, one or more of a natural quaternary polymer, a quaternary molecular compound, a metalloproteinase inhibitor, one or more anti-inflammatory agent, an acid pH control buffering system or any combination thereof, and a pharmaceutically acceptable carrier. The invention is further related to a method of treating or alleviating vaginal infection, vaginal dryness, vaginal or vulvo vaginal atrophy, vaginal itching, dyspareunia, vaginal or vulvar pain, vaginal or perivaginal inflammation or for promoting vaginal or wound healing, vaginal atrophy/dryness caused by radiotherapy, chemotherapy and/or hormonal treatment and decreased vaginal boundary lubrication or a disease or condition associated therewith or of improving vaginal boundary lubrication.

Abstract: Disclosed is a composition for intravaginal and/or for internal mucosal application, comprising an effective amount of a sulfated polysaccharide, one or more of a natural quaternary polymer, a quaternary molecular compound, a metalloproteinase inhibitor, one or more anti-inflammatory agent, an acid pH control buffering system or any combination thereof, and a pharmaceutically acceptable carrier.

Abstract: A method for noninvasive analysis of subcutaneous tissue includes irradiating a surface of the tissue with short wave infrared (SWIR) radiation in a first spectral band that is strongly absorbed by water, and with SWIR radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical. An intensity of the radiation in each of the spectral bands that emerges from the tissue is measured. A relative absorption by the tissue of radiation in one of spectral bands relative to absorption by the tissue of radiation in the other of the spectral bands is calculated. A state of the tissue is determined in accordance with the calculated relative absorption.

Abstract: Systems, devices and methods for noninvasive analysis of tissue, by irradiating a surface of the tissue with infrared radiation such that an interaction of the radiation with a component of the tissue other than water in two spectral bands is substantially identical, measuring an intensity of the radiation that emerges from the tissue in each of the spectral bands, determining change in at least one of shape and intensity of signals received by the at least one radiation detector, calculating a relative absorption by the tissue of radiation in one of the first and second spectral bands relative to absorption by the tissue of radiation in the other of the first and second spectral bands, and determining concentration of a predetermined substance, in accordance with the calculated relative absorption and in accordance with determined change in the received signal.

Abstract: A hybrid Attenuated Total Reflection fiber optic probe device having a radiation source; a detecting system; a core-only solid optical fiber probe tip having an input end and an output end; an input hollow fiber waveguide configured for association with the radiation source at a first end and interconnection with the input end of the core-only solid optical fiber probe tip at a second end; an output hollow fiber waveguide configured for interconnection with the output end of the core-only solid optical fiber probe tip at a first end and association with the detection system at a second end; an inwardly tapered solid fiber input radiation collector element configured at a tapered end for interconnection with the second end of the output hollow fiber waveguide so as to receive radiation from the radiation source; wherein an outside diameter of the core-only solid optical fiber probe tip and an inside diameter of each one of the input hollow fiber waveguide and the output hollow fiber waveguide is such that the

Abstract: The present invention relates to a composition for intravaginal and/or for internal mucosal application, comprising an effective amount of a sulfated polysaccharide, one or more of a natural quaternary polymer, a quaternary molecular compound, a metalloproteinase inhibitor, one or more anti-inflammatory agent, an acid pH control buffering system or any combination thereof, and a pharmaceutically acceptable carrier.

Abstract: A hybrid Attenuated Total Reflection fiber optic probe device having a radiation source; a detecting system; a core-only solid optical fiber probe tip having an input end and an output end; an input hollow fiber waveguide configured for association with the radiation source at a first end and interconnection with the input end of the core-only solid optical fiber probe tip at a second end; an output hollow fiber waveguide configured for interconnection with the output end of the core-only solid optical fiber probe tip at a first end and association with the detection system at a second end; an inwardly tapered solid fiber input radiation collector element configured at a tapered end for interconnection with the second end of the output hollow fiber waveguide so as to receive radiation from the radiation source; wherein an outside diameter of the core-only solid optical fiber probe tip and an inside diameter of each one of the input hollow fiber waveguide and the output hollow fiber waveguide is such that the

Abstract: An applicator device for applying a fluid substance within a body cavity includes an applicator body for insertion into the body cavity. A chamber within the applicator body holds the fluid substance. A plunger applies pressure to the fluid substance in the chamber when pushed into the chamber, and creates suction when withdrawn. Lateral openings are each provided with one-way valves that enable outflow of the fluid substance through the opening from the chamber to an outer surface of the applicator when the pressure is applied by the plunger, and inhibit inflow of a fluid through the opening from outside the applicator into the chamber when the suction is created by the plunger. A stopping structure inhibits pushing motion at a stop position, enables motion past the stop position when an additional pushing force is applied, and enables withdrawal through the stop position without interference.

Abstract: A method for noninvasive analysis of subcutaneous tissue includes irradiating a surface of the tissue with short wave infrared (SWIR) radiation in a first spectral band that is strongly absorbed by water, and with SWIR radiation in a second spectral band such that an interaction of the radiation in both spectral bands with a component of the tissue other than water is substantially identical. An intensity of the radiation in each of the spectral bands that emerges from the tissue is measured. A relative absorption by the tissue of radiation in one of spectral bands relative to absorption by the tissue of radiation in the other of the spectral bands is calculated. A state of the tissue is determined in accordance with the calculated relative absorption.

Abstract: A syringe pump including a syringe including a plunger that slides in a body which has a discharge port, a driving mechanism coupled to the syringe, including a cylinder in which a piston slides, and a plurality of biasing devices arranged about the piston operative to apply urging forces on the piston to drive the piston distally in the cylinder and thereby cause the plunger to slide in the body and discharge a substance found in the body through the discharge port, wherein if one of the biasing devices fails another of the biasing devices continues to apply a force on the piston to drive the piston distally in the cylinder, and a safety catch that initially prevents the biasing device from moving the piston, the safety catch being removable to permit the biasing device to move the piston.

Abstract: A syringe pump including a syringe including a plunger that slides in a body which has a discharge port, a driving mechanism coupled to the syringe, including a cylinder in which a piston slides, and a plurality of biasing devices arranged about the piston operative to apply urging forces on the piston to drive the piston distally in the cylinder and thereby cause the plunger to slide in the body and discharge a substance found in the body through the discharge port, wherein if one of the biasing devices fails another of the biasing devices continues to apply a force on the piston to drive the piston distally in the cylinder, and a safety catch that initially prevents the biasing device from moving the piston, the safety catch being removable to permit the biasing device to move the piston.

Abstract: An insemination device including a sperm reservoir including sperm therein, a pump in fluid communication with the sperm reservoir and operative to pump sperm therefrom, and a filter in fluid communication with the pump adapted to filter the sperm to form a sperm filtrate that has a higher fertility potential than the sperm before being filtered by the filter, wherein the filter includes a multi-layer membrane for sperm filtration, including at least one first layer with a shape and pore size for preliminary filtration of relatively large particles and at least one second layer with a shape and pore size for filtration of relatively smaller particles.

Abstract: A syringe pump including a syringe including a plunger that slides in a body which has a discharge port, a driving mechanism coupled to the syringe, including a cylinder in which a piston mounted on a shaft slides, and a biasing device operative to apply an urging force on the piston to drive the piston distally in the cylinder, and a safety catch that initially prevents the biasing device from moving the piston, the safety catch being removable to permit the biasing device to move the piston.

Abstract: An insemination device including a sperm reservoir including sperm therein, a pump in fluid communication with the sperm reservoir and operative to pump sperm therefrom, and a filter in fluid communication with the pump adapted to filter the sperm to form a sperm filtrate that has a higher fertility potential than the sperm before being filtered by the filter, wherein the filter includes a multi-layer membrane for sperm filtration, including at least one first layer with a shape and pore size for preliminary filtration of relatively large particles and at least one second layer with a shape and pore size for filtration of relatively smaller particles.

Abstract: A slow-release insemination device is disclosed, which enables in-vivo, real time sperm improvement. The present invention may minimize loss of sperm by slow-release of fluid. The sperm may be injected directly into the uterus of a female, avoiding the cervical hostile environment. The female may be free to ambulate within, for example, 2-6 hours of injection, minimizing discomfort.