Abstract: Novel solid supported intermediate products of the general formula coupled to a solid polymeric support through one or both of the R1 groups or through the R4 group which are suitable for synthesis of heterocyclic compounds are disclosed. Methods for preparing such intermediate products are also disclosed and also the use of the intermediate products in simple and fast methods on solid phase for synthesis of heterocycles.

Abstract: Novel solid supported intermediate products of the general formula coupled to a solid polymeric support through one or both of the R1 groups or through the R4 group which are suitable for synthesis of heterocyclic compounds are disclosed. Methods for preparing such intermediate products are also disclosed and also the use of the intermediate products in simple and fast methods on solid phase for synthesis of heterocycles.

Abstract: Novel solid supported intermediate products of the general formula 1

Abstract: Straight or cyclic pentapeptides with receptor affinity to .mu. or .delta. opioid receptors having a primary sequence backbone of Tyr-X-Phe-Leu-Z, Seq. ID Nos. 1, 2, and 3. X and Z can be covalently coupled to provide a heterocyclic structure according to the following conditions:i) when the pentapeptide is straight X is selected from the group consisting of Ser, Gly, Pro, AMCA and D-Ala and Z is selected from the group consisting of Glu, Gln or amino derivatives of Glu or Gln, Seq. ID No. 1, with the proviso that if X is Ser, then Z is Glu or amino derivatives of Glu; andii) where the pentapeptide is cyclic X is selected from the group consisting of D- or L-2,4-diaminobutyric acid, D- or L-lysine, D- or L-ornithine and D or L-cysteine and Z is selected from the group consisting of Gln or Glu or amino derivatives of Gln or Glu, Seq. ID No. 2, and 3, with the proviso that if X is D-or L-Cys, then Z is Cys, Seq. ID No. 3.

Abstract: A process for manufacturing crystals of growth hormone (GH) comprising the steps of:i) mixing GH with an aqueous solution comprising a buffer and a chemical compound with the general formula (1):Ar--?--CR.sub.1 R.sub.2 --!n--?--C R.sub.3 R.sub.4 --!m--C R.sub.5 R.sub.6 --OH (1)in which Ar is phenyl, alkyl-substituted phenyl, naphthyl, or alkyl-substituted naphthyl, R.sub.1 to R.sub.6 is H, OH or alkyl and n and m is 0 or 1;ii) incubating; andiii) isolating the crystals is provided. The crystals are in the form of needles, trigonal forms, cubes or parallelepipeds with a length of at least 20 microns.