Abstract: The disclosed method presents a method of fabrication of wrapped multi-scale nano-to-micro fibrous structures near-similar to extracellular matrix (ECM) structure. The resulting materials finely mingle nano-scale fibers on micro-scale fibers to form a composite structure with defined responsibility of each fiber category for diffident application including soft-tissue engineering. This composite-like structure of the fibrous material may be helpful in cell differential regulation when different cell types are necessary in a tissue. This hierarchically structure of nanofibers, as a cell-adhesive matrix, on the micro-scale fibers, as an elastomeric structural component, present a favorable structure most similar to the natural ECM and therefor acts as a growth factors for recruitment and cell proliferation within the structure.