Abstract: One aspect of the invention relates to a nucleic acid agent targeting a long non-coding RNA target selected from ENSG00000253616 (CHiLL1; SEQ ID NO 001) and ENSG00000272808 (CHiLL2; SEQ ID NO 002) for use in treatment or prevention of recurrence of non-small-cell lung cancer. In another aspect, the invention relates to a pharmaceutical composition comprising a first nucleic acid agent targeting CHiLL1 and a second nucleic acid agent targeting CHiLL2. Particular embodiments provide for the agents and compositions provided in treatment of cancers characterized by KRAS activating mutations, and/or drug resistance. Other particular embodiments provide their combination with platinum anticancer drugs.

Abstract: An example of a display control system displays, on a display device, an image of a three-dimensional space representing a real world or a virtual world. The object is arranged in the three-dimensional space on the basis of a line-of-sight direction determined in the three-dimensional space. In addition, an image in a field-of-view range, determined on the basis of the line-of-sight direction, of the three-dimensional space is displayed on the display device. The display control system arranges the object in either a first control mode in which the object is arranged on a reference plane set in the three-dimensional space or in an area near the reference plane or a second control mode in which the object is arranged away from the area. In addition, the display control system switches between the first control mode and the second control mode in accordance with the line-of-sight direction.

Abstract: A hand-held underwater net assembly with a snare closure that easily and rapidly closes the netting to prevent fish and crustaceans from escaping. The net assembly ideally includes a brightly colored net closure cord which serves to draw the netting together and close the netting when the snare handle and telescopic draw stem are proximally pulled outward and retracted by a user. The extension of the handle of the net assembly, pulls the netting into a closed position. The brightly colored net closure cord makes it easy for the underwater user to determine when the net is in the closed position and the catch is securely contained within the netting.

Abstract: A hand-held underwater net assembly with a snare closure that easily and rapidly closes the netting to prevent fish and crustaceans from escaping. The net assembly ideally includes a brightly colored net closure cord which serves to draw the netting together and close the netting when the snare handle and telescopic draw stem are proximally pulled outward and retracted by a user. The extension of the handle of the net assembly, pulls the netting into a closed position. The brightly colored net closure cord makes it easy for the underwater user to determine when the net is in the closed position and the catch is securely contained within the netting.

Abstract: An example of a display control system displays, on a display device, an image of a three-dimensional space representing a real world or a virtual world. The object is arranged in the three-dimensional space on the basis of a line-of-sight direction determined in the three-dimensional space. In addition, an image in a field-of-view range, determined on the basis of the line-of-sight direction, of the three-dimensional space is displayed on the display device. The display control system arranges the object in either a first control mode in which the object is arranged on a reference plane set in the three-dimensional space or in an area near the reference plane or a second control mode in which the object is arranged away from the area. In addition, the display control system switches between the first control mode and the second control mode in accordance with the line-of-sight direction.

Abstract: A rolling diaphragm boot is adapted for coupling to a boot-can connector. The boot includes an annular member having a longitudinal axis and a crimping lip for being received by the boot-can connector. The crimping lip has a plurality of radially distributed apertures which are oriented parallel to the longitudinal axis for reducing the stiffness and increasing the compressibility of the crimping lip.