Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

Abstract: Provided herein are compounds of Formula I, or a pharmaceutically acceptable salt thereof: which are useful as PARP inhibitors, as well as pharmaceutical compositions comprising them and methods for their use in treating disorders.

Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

Abstract: Provided herein are compounds of Formula I, or a pharmaceutically acceptable salt thereof: which are useful as PARP inhibitors, as well as pharmaceutical compositions comprising them and methods for their use in treating disorders.

Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

Abstract: Apparatus for displaying a band representation, e.g. a bar graph or column graph, of a signal comprises a series connected array of light-emission devices such as LED.s and a preferably constant current source connected to one end of the series. Transistorised control means is arranged to bypass the constant current around selected ones of the devices in dependence upon the magnitude of an input signal to be displayed so that the devices remaining lit form a band representation of the signal. A center-zero display is provided by applying an offset voltage to the input signal.

Abstract: Display apparatus receives from a transducer a voltage analogue signal representing the parameter to be measured and uses the signal to produce an illuminated band-representation of the parameter by a series of semiconductor light emission devices. A zero value of the analogue signal is represented by a band terminating intermediate the ends of the series so that positive and negative analogue values are measured, and it is indicated, for example by flashing the illuminated band on and off, when the analogue value exceeds predetermined positive and negative tolerance limits which are both within the measuring range of the apparatus, the indication being such as to draw an operator's attention to the displayed out-of tolerance value.