Patents by Inventor Rosa Armstrong

Rosa Armstrong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5413989
    Abstract: Activin is administered systemically and locally to induce the growth of mature bone. Activin enhances the level of bone formation and the quality of the bone formed when administered locally with BMP or bone marrow. Administration of activin by subcutaneous route promotes systemic increase in the bone mass.
    Type: Grant
    Filed: May 3, 1993
    Date of Patent: May 9, 1995
    Assignee: Celtrix Pharmaceuticals, Inc.
    Inventors: Yasushi Ogawa, David K. Schmidt, Rosa Armstrong, Ranga Nathan, Andrea Y. Thompson, Saeid M. Seyedin
  • Patent number: 5393739
    Abstract: Bone morphogenetic proteins -2 and -3 (BMPs -2 and -3) work in synergistic combination with TGF-.beta.z to provide compositions with increased osteogenic activity. Methods of treating bone defects, inducing bone growth and increasing bone marrow cell production using these compositions are also disclosed.
    Type: Grant
    Filed: September 15, 1993
    Date of Patent: February 28, 1995
    Assignee: Celtrix Pharmaceuticals, Inc.
    Inventors: Hanne Bentz, Andrea Y. Thompson, Rosa Armstrong, David M. Rosen
  • Patent number: 5258029
    Abstract: Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optionally in combination with a TGF-beta cofactor, in a pharmaceutically acceptable carrier. The carrier is preferably either a collagen composition or a ceramic.
    Type: Grant
    Filed: May 23, 1990
    Date of Patent: November 2, 1993
    Assignee: Collagen Corporation
    Inventors: George H. Chu, Rosa Armstrong, Robert Chang
  • Patent number: 5207710
    Abstract: Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optionally in combination with a TGF-beta cofactor, in a pharmaceutically acceptable carrier. The carrier is preferably either a collagen composition or a ceramic.
    Type: Grant
    Filed: January 10, 1992
    Date of Patent: May 4, 1993
    Assignee: Collagen Corporation
    Inventors: George H. Chu, Rosa Armstrong, Robert Chang
  • Patent number: 5208219
    Abstract: Activin is administered systemically and locally to induce the growth of mature bone. Activin enhances the level of bone formation and the quality of the bone formed when administered locally with BMP or bone marrow. Administration of activin by subcutaneous route promotes systemic increase in the bone mass.
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: May 4, 1993
    Assignee: Celtrix Pharmaceuticals Inc.
    Inventors: Yasushi Ogawa, David K. Schmidt, Rosa Armstrong, Ranga Nathan, Andrea Y. Thompson, Saeid M. Seyedin
  • Patent number: 5118667
    Abstract: Bone growth factors are used to stimulate new bone formation when administered with agents that inhibit bone resorption. These therapeutic combinations result in an enhanced rate of bone formation with an increase in bone mass.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: June 2, 1992
    Assignee: Celtrix Pharmaceuticals, Inc.
    Inventors: Steven W. Adams, Rosa Armstrong, David Rosen
  • Patent number: 5108436
    Abstract: Stress-bearing prostheses for replacement or partial replacement of stress-bearing bone are fixed in place by bony ingrowth by providing a stress-bearing member having a porous region in combination with an osteogenic factor extract or a purified osteogenic inductive protein, optionally in combination with a TGF-beta cofactor, in a pharmaceutically acceptable carrier. The carrier is preferably either a collagen composition or a ceramic.
    Type: Grant
    Filed: November 23, 1988
    Date of Patent: April 28, 1992
    Assignee: Collagen Corporation
    Inventors: George H. Chu, Rosa Armstrong, Robert Chang
  • Patent number: 5008240
    Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration or activator or cofactor for efficacy.
    Type: Grant
    Filed: August 9, 1988
    Date of Patent: April 16, 1991
    Assignee: Collagen Corporation
    Inventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 4971952
    Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-beta). The CIF may be administered locally or systemically, depending upon the indication, and does not require coadministration of activator or cofactor for efficacy.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: November 20, 1990
    Assignee: Collagen Corporation
    Inventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 4843063
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to hmogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: June 8, 1988
    Date of Patent: June 27, 1989
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 4810691
    Abstract: Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: March 7, 1989
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 4806523
    Abstract: Inflammation, acute and/or chronic, is treated with a CIF (TGF-.beta.). The CIF may be administered locally or symstemically, depending upon the indication, and does not require coadministraion of activator or cofactor for efficacy.
    Type: Grant
    Filed: March 6, 1986
    Date of Patent: February 21, 1989
    Assignee: Collagen Corporation
    Inventors: Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 4789663
    Abstract: A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats.
    Type: Grant
    Filed: July 5, 1985
    Date of Patent: December 6, 1988
    Assignee: Collagen Corporation
    Inventors: Donald G. Wallace, Thomas L. Smestad, John M. McPherson, Karl A. Piez, Saeid Seyedin, Rosa Armstrong
  • Patent number: 4774322
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 27, 1988
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: 4774228
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: December 10, 1987
    Date of Patent: September 27, 1988
    Assignee: Collagen Corporation
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: RE34090
    Abstract: Two proteins that are found is bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: March 5, 1991
    Date of Patent: October 6, 1992
    Assignee: Celtrix Laboratories, Inc.
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong
  • Patent number: RE35694
    Abstract: Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-.beta. assay. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each is reduced to a single polypeptide indicating that the proteins are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta. whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two proteins may be purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: December 16, 1997
    Assignee: Celtrix Pharmaceuticals, Inc.
    Inventors: Saeid Seyedin, Thomas Thomas, Hanne Bentz, Larry Ellingsworth, Rosa Armstrong