Patents by Inventor Rosa Maria Ayala Diaz

Rosa Maria Ayala Diaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining the presence or absence of minimal residual disease (MRD) in a subject who has been treated for a disease
    Patent number: 11781189
    Abstract: The present invention is focused on a method, kit and system for determining the presence or absence of minimal residual disease in a subject who has been treated for a proliferative disease wherein said method, kit and system comprise: (A) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject prior to treatment for said disease, to obtain a first list of characters reading from left to right; (B) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject after treatment for said disease, to obtain a second list of characters reading from left to right, wherein when a nucleotide sequence is mutated it is a genetic marker for said proliferative disease; (C) determining, for each second list of characters obtained in step (B), the degree of similarity, DS, with each first list of characters obtained in step (A); (D) selecting, for each second list of c
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: October 10, 2023
    Inventors: Santiago Barrio García, Rosa María Ayala Díaz, María Inmaculada Rapado Martinez, Eva María Garrido Martín, Luis Paz-Ares Rodriguez, Maria Esther Onecha De La Fuente, Joaquín Martínez López
  • Method of treatment of disease and method for quantifying the level of minimal residual disease in a subject
    Patent number: 11702692
    Abstract: The present invention belongs to the field of diagnosis of disease.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: July 18, 2023
    Inventors: Santiago Barrio García, Joaquín Martínez López, Carlos Marín Sebastián, María Inmaculada Rapado Martínez, Rosa María Ayala Díaz, Beatriz Sánchez Vega Carrión
  • METHOD FOR DETERMINING THE PRESENCE OR ABSENCE OF MINIMAL RESIDUAL DISEASE (MRD) IN A SUBJECT WHO HAS BEEN TREATED FOR A DISEASE
    Publication number: 20220380852
    Abstract: The present invention is focused on a method, kit and system for determining the presence or absence of minimal residual disease in a subject who has been treated for a proliferative disease wherein said method, kit and system comprise: (A) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject prior to treatment for said disease, to obtain a first list of characters reading from left to right; (B) amplifying and sequencing at least one nucleotide sequence comprised in genomic DNA from a biological sample obtained from said subject after treatment for said disease, to obtain a second list of characters reading from left to right, wherein when a nucleotide sequence is mutated it is a genetic marker for said proliferative disease; (C) determining, for each second list of characters obtained in step (B), the degree of similarity, DS, with each first list of characters obtained in step (A); (D) selecting, for each second list of c
    Type: Application
    Filed: August 27, 2020
    Publication date: December 1, 2022
    Inventors: Santiago BARRIO GARCÍA, Rosa María AYALA DÍAZ, María Inmaculada RAPADO MARTINEZ, Eva María GARRIDO MARTÍN, Luis PAZ-ARES RODRIGUEZ, María Esther ONECHA DE LA FUENTE, Joaquín MARTÍNEZ LÓPEZ
  • Method of Treatment of Disease and Method for Quantifying the Level of Minimal Residual Disease in a Subject
    Publication number: 20190017114
    Abstract: The present invention belongs to the field of diagnosis of disease.
    Type: Application
    Filed: February 16, 2018
    Publication date: January 17, 2019
    Inventors: Santiago Barrio Garcia, Joaquin Martinez Lopez, Carlos Marin Sebastian, Maria Inmaculada Rapado Martinez, Rosa Maria Ayala Diaz, Beatriz Sanchez Vega Carrion
  • METHOD FOR QUANTIFYING THE LEVEL OF MINIMAL RESIDUAL DISEASE IN A SUBJECT
    Publication number: 20180127821
    Abstract: The present invention belongs to the field of diagnosis of disease.
    Type: Application
    Filed: December 20, 2017
    Publication date: May 10, 2018
    Inventors: Santiago BARRIO GARCÍA, Joaquín MARTÍNEZ LÓPEZ, Carlos MARÍN SEBASTIÁN, María Inmaculada RAPADO MARTÍNEZ, Rosa María AYALA DÍAZ, Beatriz SÁNCHEZ VEGA CARRIÓN
  • METHOD FOR QUANTIFYING THE LEVEL OF MINIMAL RESIDUAL DISEASE IN A SUBJECT
    Publication number: 20160122819
    Abstract: The present invention belongs to the field of diagnosis of disease.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Inventors: Santiago BARRIO GARCÍA, Joaquín MARTÍNEZ LÓPEZ, Carlos MARÍN SEBASTIÁN, María Inmaculada RAPADO MARTÍNEZ, Rosa María AYALA DÍAZ, Beatriz SÁNCHEZ VEGA CARRIÓN