Patents by Inventor Rosa Peracaula

Rosa Peracaula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLYOSYLATION MARKERS FOR CANCER AND CHRONIC INFLAMMATION
    Publication number: 20110143351
    Abstract: The present invention provides novel biomarkers for use in the diagnosis and prognosis of cancerous and malignant conditions and further of diseases which are mediated by a proinflammatory immune response. The biomarkers are glycoproteins, the levels of expression of which have been correlated by the inventors to correspond to particular disease conditions. The invention further extends to methods for use in monitoring the response to therapy of a treatment for use in the treatment of a cancerous condition or proinflammatory disease.
    Type: Application
    Filed: July 21, 2008
    Publication date: June 16, 2011
    Inventors: Pauline Rudd, James Arnold, Radka Saldova, Louise Royle, Umi Marshida Abd Hamid, Raymond Dwek, Rosa Peracaula, Rafael De Llorens
  • Glycosylation markers for cancer diagnosing and monitoring
    Patent number: 7892752
    Abstract: One can identify and quantify one or more glycosylation markers of cancer by utilizing quantitative HPLC analysis of glycans which have been released from unpurified glycoproteins. The unpurified glycoproteins can be total glycoproteins or a selection of the total glycoproteins. The identified glycosylation marker can be a native glycan or a digestion product which has been segregated and amplified by exoglycosidase digestions. One can utilize the identified glycosylation marker, for example, for diagnosing and/or monitoring cancer in a subject. One can also use the glycosylation marker to identify glycoprotein biomarkers that carry the glycosylation marker. Such biomarkers can also be used for monitoring and/or diagnosing cancer. The biomarker may also be a subset of glycoforms of a glycoprotein that are separated in trains of spots on 2D gel.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: February 22, 2011
    Inventors: Raymond A. Dwek, Umi Marshida Abd Hamid, Rafael de Llorens, Rosa Peracaula, Catherine M. Radcliffe, John Robertson, Louise Royle, Pauline M. Rudd, Nicole Zitzmann
  • Glycosylation markers for cancer diagnosing and monitoring
    Publication number: 20060269974
    Abstract: One can identify and quantify one or more glycosylation markers of cancer by utilizing quantitative HPLC analysis of glycans which have been released from unpurified glycoproteins. The unpurified glycoproteins can be total glycoproteins or a selection of the total glycoproteins. The identified glycosylation marker can be a native glycan or a digestion product which has been segregated and amplified by exoglycosidase digestions. One can utilize the identified glycosylation marker, for example, for diagnosing and/or monitoring cancer in a subject. One can also use the glycosylation marker to identify glycoprotein biomarkers that carry the glycosylation marker. Such biomarkers can also be used for monitoring and/or diagnosing cancer. The biomarker may also be a subset of glycoforms of a glycoprotein that are separated in trains of spots on 2D gel.
    Type: Application
    Filed: April 26, 2006
    Publication date: November 30, 2006
    Inventors: Raymond Dwek, Umi Hamid, Rafael Llorens, Rosa Peracaula, Catherine Radcliffe, John Robertson, Louise Royle, Pauline Rudd, Nicole Zitzmann