Patents by Inventor Rosa Rademakers

Rosa Rademakers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detecting and treating dementia
    Patent number: 9486541
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: November 8, 2016
    Assignees: Mayo Foundation for Medical Education and Research, VIB VZW, Universteit Antwerpen, The University of British Columbia, The University of Manchester
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • DETECTING FRONTOTEMPORAL DEMENTIA AND AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20140255936
    Abstract: This document provides methods and materials for detecting a nucleic acid expansion. For example, methods and materials for detecting the presence of an expanded number (e.g., greater than 30, 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, or more copies) of a hexanucleotide repeat (e.g., GGGGCC) in the non-coding region of a C9ORF72 gene are provided.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 11, 2014
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Rosa Rademakers, Mariely DeJesus Hernandez
  • DETECTING AND TREATING DEMENTIA
    Publication number: 20130345142
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Application
    Filed: July 1, 2013
    Publication date: December 26, 2013
    Applicants: Mayo Foundation for Medical Education and Research, Vib VZW, The University of Manchester, The University of British Columbia, Universiteit Antwerpen
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • Detecting and treating dementia
    Patent number: 8486635
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: July 16, 2013
    Assignees: Mayo Foundation for Medical Education and Research, The University of British Columbia, The University of Manchester, VIB VZW, Universiteit Antwerpen
    Inventors: Michael L. Hutton, Matthew Charles Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts, Ashley Diane Cannon
  • DETECTING AND TREATING DEMENTIA
    Publication number: 20100105034
    Abstract: This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
    Type: Application
    Filed: May 30, 2007
    Publication date: April 29, 2010
    Inventors: Michael L. Hutton, Matthew Colin Baker, Jennifer Mae Gass, Rosa Rademakers, Jason Eriksen, Stuart M. Pickering-Brown, Ian Reid Alexander Mackenzie, Howard Feldman, Samir Kumar-Singh, Christine Van Broeckhoven, Marc Cruts
  • METHODS AND MATERIALS FOR DETECTING AND TREATING DEMENTIA
    Publication number: 20090291444
    Abstract: This document relates to methods and materials involved in detecting mutations linked to dementia (e.g., frontotemporal lobar degeneration). For example, methods and materials for determining whether or not a mammal is homozygous for a mutant T allele of rs5848 are provided. This document also relates to methods and materials involved in treating mammals having or being susceptible to developing neurodegenerative disorders (e.g., frontotemporal lobar degeneration). For example, methods and materials for inhibiting the ability of miRNA to suppress GRN polypeptide expression in mammals are provided.
    Type: Application
    Filed: March 30, 2009
    Publication date: November 26, 2009
    Inventors: Jason Eriksen, Dennis W. Dickson, Matthew C. Baker, Rosa Rademakers, Todd Robinson