Abstract: The present invention relates to methods and combination therapies for enhancing the activity and function of non-B cell immune cells (such as T cells) using genetically modified B cells. These methods and combinations can be used, for example, for the treatment of a variety of diseases and disorders, including cancer, heart disease, inflammatory disease, muscle wasting disease, neurological disease, and the like.

Abstract: An emergency shut-off device for use in the event of the breakage of pipes (2) for conveying fluids includes two adjacent valves (4) arranged in series in the pipe (2) wherein each valve (4) includes a hollow body (8) having a joint (14,12) with a predetermined breaking load for joining it to the body (8) of the other valve (2) and connectors (12,18) for connecting it to the adjacent portion of pipe (2). An obturator (24) is rotatable in the body (8) so that it can assume a shut-off position transverse the pipe (2) and an open position substantially perpendicular to its shut-off position. The obturator (24) has an engagement device (40) for engaging the obturator (24) of the other valve (4) fixing the two obturators (24) in a contiguous arrangement in their open positions, which they assume normally, and releasing the obturators (24) so that they can assume their shut-off configurations when the valves (4) move apart because the joint has been subjected to loads equal to or greater than the breaking load.