Patents by Inventor Rosalia Kaufman

Rosalia Kaufman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the CNS
    Patent number: 11406670
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 9, 2022
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • METHOD OF IDENTIFYING AGENTS THAT AFFECT MATURATION, SURVIVAL AND MYELINATION
    Publication number: 20200003757
    Abstract: The present invention discloses a method of identifying agents that affect maturation and survival of oligodendrocytes or myelination of neuronal cells using ex-vivo differentiated embryonic stem cells.
    Type: Application
    Filed: July 15, 2019
    Publication date: January 2, 2020
    Applicant: KADIMASTEM, LTD.
    Inventors: Michel Revel, Judith Chebath, Arye Hasson, Michal Izrael, Rosalia Kaufman
  • METHODS OF GENERATING GLIAL AND NEURONAL CELLS AND USE OF SAME FOR THE TREATMENT OF MEDICAL CONDITIONS OF THE CNS
    Publication number: 20190175658
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Application
    Filed: February 21, 2019
    Publication date: June 13, 2019
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the CNS
    Patent number: 10258651
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: April 16, 2019
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • METHODS OF GENERATING GLIAL AND NEURONAL CELLS AND USE OF SAME FOR THE TREATMENT OF MEDICAL CONDITIONS OF THE CNS
    Publication number: 20170362570
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Application
    Filed: March 23, 2017
    Publication date: December 21, 2017
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the CNS
    Patent number: 9631175
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: April 25, 2017
    Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • Insulin producing cells derived from pluripotent stem cells
    Patent number: 9404087
    Abstract: A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: August 2, 2016
    Assignee: Kadimastem Ltd.
    Inventors: Michel Revel, Judith Chebath, Guy Slutsky, Alon Levy, Michal Izrael, Arik Hasson, Kfir Molakandov, Rosalia Kaufman
  • METHODS OF GENERATING GLIAL AND NEURONAL CELLS AND USE OF SAME FOR THE TREATMENT OF MEDICAL CONDITIONS OF THE CNS
    Publication number: 20140322179
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Application
    Filed: July 11, 2014
    Publication date: October 30, 2014
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • METHOD OF IDENTIFYING AGENTS THAT AFFECT MATURATION, SURVIVAL AND MYELINATION
    Publication number: 20140296107
    Abstract: The present invention discloses a method of identifying agents that affect maturation and survival of oligodendrocytes or myelination of neuronal cells using ex-vivo differentiated embryonic stem cells.
    Type: Application
    Filed: August 5, 2012
    Publication date: October 2, 2014
    Applicant: KADIMASTEM, LTD.
    Inventors: Michel Revel, Judith Chebath, Arye Hasson, Michal Izrael, Rosalia Kaufman
  • Methods of generating mature oligodendrocytes
    Patent number: 8809052
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: August 19, 2014
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman
  • INSULIN PRODUCING CELLS DERIVED FROM PLURIPOTENT STEM CELLS
    Publication number: 20130273013
    Abstract: A method of generating islet cells from pluripotent stem cells is disclosed. The method comprises: (a) culturing the pluripotent stem cells in a differentiation medium so as to differentiate the pluripotent stem cells into endoderm cells; and (b) culturing the endoderm cells in a medium comprising at least one growth factor, a cAMP inducer and retinoic acid (RA), said at least one growth factor being selected from the group consisting of FGF10, bFGF and FGF7 so as to generate further differentiated cells; and (c) culturing the further differentiated cells in a medium comprising a maturation factor selected from the group consisting of nicotinamide, GLP-1 and exendin 4, thereby generating islet cells from pluripotent stem cells. Further methods of generating islet cells are also disclosed, isolated cell populations comprising same and uses thereof.
    Type: Application
    Filed: December 15, 2011
    Publication date: October 17, 2013
    Inventors: Michel Revel, Judith Chebath, Guy Slutsky, Alon Levy, Michal Izrael, Arik Hasson, Molakandov Kfir, Rosalia Kaufman
  • Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns
    Publication number: 20100003751
    Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
    Type: Application
    Filed: August 15, 2007
    Publication date: January 7, 2010
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Michel Revel, Judith Chebath, Michal Izrael, Rosalia Kaufman