Patents by Inventor Rosalyn D. Blumenthal

Rosalyn D. Blumenthal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of determining cytokine dosage for improving myelosuppressive state
    Patent number: 7465551
    Abstract: The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose. Measured levels of one or more cytokines in a patient subjected to cytotoxic therapy, relative to a normal population, may be used to determine the dose of a hematopoietic cytokine to be administered to the patient.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: December 16, 2008
    Assignee: Center For Molecular Medicine and Immunology
    Inventors: Rosalyn D. Blumenthal, David M. Goldenberg
  • Method of evaluating myelosuppressive state
    Patent number: 7279289
    Abstract: The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: October 9, 2007
    Assignee: Center for Molecular Medicine and Immunology
    Inventors: Rosalyn D. Blumenthal, David M. Goldenberg
  • Method of determining cytokine dosage for myelosuppressive state
    Patent number: 7112409
    Abstract: The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: September 26, 2006
    Assignee: Center for Molecular Medicine and Immunology
    Inventors: Rosalyn D. Blumenthal, David M. Goldenberg
  • Use of antioxidants to mitigate radioimmunotherapy-induced radiation toxicity
    Publication number: 20040265231
    Abstract: The instant invention provides a method of using antioxidant, e.g., vitamins, as radioprotective agents to mitigate gastrointestinal and hemopoietic toxicity of the radioimmunotherapy., The instant invention further provides a method of combining the administration of antioxidant with BMT to produce an additive radioprotective effect against radiation damage to healthy tissues during the radioimmunotherapy.
    Type: Application
    Filed: July 19, 2004
    Publication date: December 30, 2004
    Applicant: Center for Molecular Medicine and Immunology
    Inventors: Rosalyn D. Blumenthal, David M. Goldenberg
  • Method of evaluating myelosuppressive state
    Patent number: 6649352
    Abstract: The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: November 18, 2003
    Assignee: Center for Molecular Medicine and Immunology
    Inventors: Rosalyn D. Blumenthal, Walter Lew, Malik Juweid, Rita Alisauskas, Zhiliang Ying, David M. Goldenberg
  • Method of detecting endometriosis
    Patent number: 6540980
    Abstract: Kits for detecting and treating endometriosis are provided, which contain a targeting molecule comprising an eosinophil peroxidase-binding component. Methods of detecting and treating endometriosis using eosinophil peroxidase-specific targeting molecules are also provided Targeting molecules comprise an eosinophil peroxidase-binding component and an accessory component; the accessory component comprising an agent conferring detectability or a therapeutic effect.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 1, 2003
    Assignee: Center for Molecular Medicine and Immunology
    Inventors: Rosalyn D. Blumenthal, David M. Goldenberg, Michael Samoszuk