Patents by Inventor Rosamund Carol Smith

Rosamund Carol Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants of human GDNF
    Patent number: 9243046
    Abstract: The present invention relates to novel variants of human glial cell-derived neurotrophic factor (GDNF) and methods for their use.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: January 26, 2016
    Assignee: Eli Lilly and Company
    Inventors: Donmienne Doen Mun Leung, Jirong Lu, Kalpana Mahesh Merchant, Mahmoud Ghanem, Linda Maureen O'Bryan, Rosamund Carol Smith
  • Therapeutic uses of soluble alpha-Klotho
    Patent number: 8778887
    Abstract: The present invention relates to therapeutic uses of soluble alpha-Klotho.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: July 15, 2014
    Assignee: Eli Lilly and Company
    Inventors: Matthew Douglas Breyer, Linda Maureen O'Bryan, Rosamund Carol Smith
  • VARIANTS OF HUMAN GDNF
    Publication number: 20130324474
    Abstract: The present invention relates to novel variants of human glial cell-derived neurotrophic factor (GDNF) and methods for their use.
    Type: Application
    Filed: April 3, 2012
    Publication date: December 5, 2013
    Applicant: Eli Lilly and Company
    Inventors: Donmienne Doen Mun Leung, Jirong Lu, Kalpana Mahesh Merchant, Mahmoud Ghanem, Linda Maureen O'Bryan, Rosamund Carol Smith
  • THERAPEUTIC USES OF SOLUBLE ALPHA-KLOTHO
    Publication number: 20120232024
    Abstract: The present invention relates to therapeutic uses of soluble alpha-Klotho.
    Type: Application
    Filed: December 15, 2010
    Publication date: September 13, 2012
    Applicant: ELI LILLY AND COMPANY
    Inventors: Matthew Douglas Breyer, Linda Maureen O'Bryan, Rosamund Carol Smith
  • Anti-myostatin antibodies
    Patent number: 8066995
    Abstract: Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bond density, or for the treatment of various disorders in mammalian and avian species, X17251.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: November 29, 2011
    Assignee: Eli Lilly and Company
    Inventors: Julian Davies, Bryan Edward Jones, Andrew Ihor Korytko, Pamela Jean Mitchell, Rosamund Carol Smith, Linda O'Bryan (Nee Tobias), Rong Wang
  • Anti-myostatin antibodies
    Patent number: 7745583
    Abstract: A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing hone density, or for the treatment of various disorders in mammalian and avian species.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: June 29, 2010
    Assignee: Eli Lilly and Company
    Inventors: Bomie Han, Andrew Ihor Korytko, Pamela Jean Mitchell, Rosamund Carol Smith, Linda O'Bryan (Nee Tobias), Rong Wang
  • ANTI-MYOSTATIN ANTIBODIES
    Publication number: 20100087631
    Abstract: A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may he chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing hone density, or for the treatment of various disorders in mammalian and avian species.
    Type: Application
    Filed: November 4, 2009
    Publication date: April 8, 2010
    Applicant: ELI LILLY AND COMPANY
    Inventors: BOMIE HAN, ANDREW KORYTKO, PAMELA JEAN MITCHELL, LINDA O'BRYAN (NEE TOBIAS), RONG WANG, ROSAMUND CAROL SMITH
  • ANTI-MYOSTATIN ANTIBODIES
    Publication number: 20100080811
    Abstract: Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
    Type: Application
    Filed: November 3, 2009
    Publication date: April 1, 2010
    Inventors: JULIAN DAVIES, BRYAN EDWARD JONES, ANDREW IHOR KORYTKO, PAMELA JEAN MITCHELL, ROSAMUND CAROL SMITH, LINDA MAUREEN O'BRYAN (NEE TOBIAS), RONG WANG
  • Anti-myostatin antibodies
    Patent number: 7635760
    Abstract: A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: December 22, 2009
    Assignee: Eli Lilly and Company
    Inventors: Bomie Han, Andrew Korytko, Pamela Jean Mitchell, Linda O'Bryan, Rong Wang, Rosamund Carol Smith
  • Anti-myostatin antibodies
    Patent number: 7632499
    Abstract: Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: December 15, 2009
    Assignee: Eli Lilly and Company
    Inventors: Julian Davies, Bryan Edward Jones, Andrew Ihor Korytko, Pamela Jean Mitchell, Rosamund Carol Smith, Linda Maureen O'Bryan, Rong Wang
  • ANTI-MYOSTATIN ANTIBODIES
    Publication number: 20090131638
    Abstract: Anti-myostatin antibodies are identified that are characterized as having high affinity and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
    Type: Application
    Filed: October 5, 2006
    Publication date: May 21, 2009
    Inventors: Julian Davies, Bryan Edward Jones, Andrew Ihor Korytko, Pamela Jean Mitchell, Rosamund Carol Smith, Linda Maureen O'Bryan (nee Tobias), Rong Wang
  • Anti-Myostatin Antibodies
    Publication number: 20080299126
    Abstract: A neutralizing epitope is identified within amino acids 40-64 of the mature form of human myostatin. Antibodies that bind this epitope with high affinity preferentially bind GDF-8 over GDF-11 and may be chimeric, humanized or fully human antibodies, immunoconjugates of the antibodies or antigen-binding fragments thereof. The antibodies of the invention are useful for increasing muscle mass, increasing bone density, or for the treatment of various disorders in mammalian and avian species.
    Type: Application
    Filed: October 5, 2006
    Publication date: December 4, 2008
    Inventors: Bomie Han, Andrew Korytko, Pamela Jean Mitchell, Linda O'Bryan (nee Tobias), Rong Wang, Rosamund Carol Smith
  • Lp mammalian proteins; related reagents
    Publication number: 20040126777
    Abstract: Isolated nucleic acid molecules encoding polypeptides from a human, reagents related thereto (including purified polypeptidesspecific antibodies) are provided. Methods of using said reagentsand diagnostic kits are also provided.
    Type: Application
    Filed: July 25, 2003
    Publication date: July 1, 2004
    Inventors: Ramesh Rajani Bhatt, John Nels Calley, Josef Georg Heuer, Gerald Patrick Keleher, Joanne Sloan Lancaster, Qingqin Li, Deshun Lu, Bradley Jay Mills, Santosh Kumar Mishra, Douglas Raymond Perkins, Scott William Rowlinson, Rosamund Carol Smith, Eric Wen Su, He Wang, Yu Zhi
  • Nucleic acids, vectors, host cells, polypeptides, and uses thereof
    Publication number: 20030215913
    Abstract: The present invention provides nucleic acid sequences encoding novel human proteins. These novel nucleic acids are useful for constructing the claimed DNA vectors and host cells of the invention and for preparing the claimed recombinant proteins and antibodies that are useful in the claimed methods and medical uses.
    Type: Application
    Filed: December 18, 2002
    Publication date: November 20, 2003
    Inventors: Enrique Alvarez, Jacquelyn Kaye McEntire, Rosamund Carol Smith, Eric Wen Su