Patents by Inventor Rosana Esteller

Rosana Esteller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240359016
    Abstract: An Implantable Pulse Generator (IPG) or External Trial Stimulator (ETS) system is disclosed that is capable of sensing an Evoked Compound Action Potential (ECAP), and (perhaps in conjunction with an external device) is capable of adjusting a stimulation program while keeping a location of a Central Point of Stimulation (CPS) constant. Specifically, one or more features of measured ECAP(s) indicative of its shape and size are determined, and compared to thresholds or ranges to modify the electrode configuration of the stimulation program.
    Type: Application
    Filed: May 14, 2024
    Publication date: October 31, 2024
    Inventors: Rosana Esteller, Goran N. Marnfeldt, Natalie A. Brill, David M. Wagenbach, Pujitha Weerakoon, Jordi Parramon
  • Patent number: 12130753
    Abstract: An implantable device includes a memory and a processor coupled to the memory and configured to perform actions, including: receiving electrical signals from tissue of a patient; and in response to each of a plurality of triggers, storing a portion of the received electrical signals, occurring after the trigger and extending for a limited duration, in the memory on a first-in-first-out basis. Another an implantable device includes a memory; and a processor coupled to the memory and configured to perform actions, including: receiving electrical signals from tissue of a patient; and in response to each of a plurality of triggers, determining at least one feature of the received electrical signals; and storing the at least one feature in the memory on a first-in-first-out basis.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: October 29, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventor: Rosana Esteller
  • Publication number: 20240335653
    Abstract: A method is disclosed for programming a patient's stimulator device using an external device. The method provides a Graphical User Interface (GUI) on the external device that allows the patient to select from a plurality of displayed stimulation modes to program stimulation provided by one or more electrodes of the stimulator device. The external device stores a model derived for the patient, which model comprises information indicative of a plurality of frequency/pulse width/amplitude coordinates predicted to provide optimal stimulation for the patient. Each stimulation mode corresponds with a subset of coordinates defined in accordance with the plurality of coordinates in the model. Selection of one of the stimulation modes limits programming the stimulator device with coordinates that are within the corresponding subset of coordinates.
    Type: Application
    Filed: June 20, 2024
    Publication date: October 10, 2024
    Inventors: Ismael Huertas Fernandez, Que T. Doan, Changfang Zhu, Rosana Esteller, Michael A. Moffitt
  • Publication number: 20240335655
    Abstract: Disclosed are solutions for providing a sensing reference electrode useful for sensing tissue signal in a Deep Brain Stimulation application. The sensing reference electrode is head-positioned and placed proximate to the patient's brain tissue, but not within the brain tissue itself where the primary sensing electrode is located. The sensing reference electrode may be placed under the scalp, within a burr hole plug used to secure the DBS leads, or within the cerebrospinal fluid just under the skull. The sensing reference electrode can comprise one or more electrodes on a scalp-implantable lead separate from the brain-implantable lead that includes the primary sensing electrodes. The sensing reference electrode can also comprise an additional electrode added to an otherwise standard brain-implantable lead, with the sensing reference electrode being significantly proximal on the lead such that it is not brain-implantable.
    Type: Application
    Filed: March 20, 2024
    Publication date: October 10, 2024
    Inventors: Rosana Esteller, Goran Marnfeldt, Peter Yoo
  • Publication number: 20240316352
    Abstract: A sensing electrode selection algorithm is disclosed for use with an implantable pulse generator having an electrode array. The algorithm automatically selects optimal sensing electrodes in the array to be used with a pre-determined stimulation therapy appropriate for the patient. The algorithm preferably senses stimulation artifacts using different sensing electrodes, and more specifically different sensing electrode pairs as is appropriate when differential sensing is used. The algorithm further preferably senses these stimulation artifacts with the patient placed in two or more postures. The algorithm processes the stimulation artifact features measured at the different sensing electrodes and at the different postures to automatically determine one or more sensing electrode pairs that best distinguishes the two or more postures given the prescribed stimulation therapy.
    Type: Application
    Filed: June 6, 2024
    Publication date: September 26, 2024
    Inventors: Tianhe Zhang, Rosana Esteller, Thomas W. Stouffer
  • Patent number: 12053632
    Abstract: Methods and systems for making adjustments to electrical stimulation based on patient-specific factors can includes the following instructions or actions: receiving information regarding at least one of i) electrical response of patient tissue, ii) patient response to stimulation, or iii) an arrangement of the implanted lead or the electrodes of the implanted lead with respect to patient anatomy; and calculating an electrode weight for each of a plurality of the electrodes of the implanted lead based on the received information.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: August 6, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Jessica Block, Andrew James Haddock, Rosana Esteller
  • Publication number: 20240238591
    Abstract: Methods and systems for spinal cord stimulation (SCS) are disclosed. The methods and systems involve using electrode leads implanted within the patient's spinal column to record neural responses evoked by the stimulation. The disclosed neural responses are different in several respects from electrical responses that have previously been measured in the context of SCS, such as stimulation artifacts and evoked compound action potentials (ECAPs). The disclosed neural responses typically occur later in time following the evoking stimulation pulse. Another distinguishing feature is that disclosed neural responses are generally most prominently observed with consistent, relatively unchanging amplitudes when the evoking stimulation frequency is ultra-low, for example, about 10 Hz or less.
    Type: Application
    Filed: December 21, 2023
    Publication date: July 18, 2024
    Inventors: Tianhe Zhang, Rosana Esteller, Rafael Carbunaru
  • Publication number: 20240226558
    Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.
    Type: Application
    Filed: March 21, 2024
    Publication date: July 11, 2024
    Inventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
  • Patent number: 12023505
    Abstract: A sensing electrode selection algorithm is disclosed for use with an implantable pulse generator having an electrode array. The algorithm automatically selects optimal sensing electrodes in the array to be used with a pre-determined stimulation therapy appropriate for the patient. The algorithm preferably senses stimulation artifacts using different sensing electrodes, and more specifically different sensing electrode pairs as is appropriate when differential sensing is used. The algorithm further preferably senses these stimulation artifacts with the patient placed in two or more postures. The algorithm processes the stimulation artifact features measured at the different sensing electrodes and at the different postures to automatically determine one or more sensing electrode pairs that best distinguishes the two or more postures given the prescribed stimulation therapy.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: July 2, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Tianhe Zhang, Rosana Esteller, Thomas W. Stouffer
  • Patent number: 12017074
    Abstract: An Implantable Pulse Generator (IPG) or External Trial Stimulator (ETS) system is disclosed that is capable of sensing an Evoked Compound Action Potential (ECAP), and (perhaps in conjunction with an external device) is capable of adjusting a stimulation program while keeping a location of a Central Point of Stimulation (CPS) constant. Specifically, one or more features of measured ECAP(s) indicative of its shape and size are determined, and compared to thresholds or ranges to modify the electrode configuration of the stimulation program.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: June 25, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Rosana Esteller, Goran N. Marnfeldt, Natalie A. Brill, David M. Wagenbach, Pujitha Weerakoon, Jordi Parramon
  • Patent number: 12017061
    Abstract: A method is disclosed for programming a patient's stimulator device using an external device. The method provides a Graphical User Interface (GUI) on the external device that allows the patient to select from a plurality of displayed stimulation modes to program stimulation provided by one or more electrodes of the stimulator device. The external device stores a model derived for the patient, which model comprises information indicative of a plurality of frequency/pulse width/amplitude coordinates predicted to provide optimal stimulation for the patient. Each stimulation mode corresponds with a subset of coordinates defined in accordance with the plurality of coordinates in the model. Selection of one of the stimulation modes limits programming the stimulator device with coordinates that are within the corresponding subset of coordinates.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: June 25, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Ismael Huertas Fernandez, Que T. Doan, Changfang Zhu, Rosana Esteller, Michael A. Moffitt
  • Patent number: 11998743
    Abstract: Methods and systems for providing closed loop control of stimulation provided by an implantable stimulator device are disclosed herein. The disclosed methods and systems use a neural feature prediction model to predict a neural feature, which is used as a feedback control variable for adjusting stimulation. The predicted neural feature is determined based on one or more stimulation artifact features. The disclosed methods and systems can be used to provide closed loop feedback in situations, such as sub-perception therapy, when neural features cannot be readily directly measured.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: June 4, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Rosana Esteller, Tianhe Zhang, Qi An, Gezheng Wen
  • Patent number: 11998745
    Abstract: Methods and systems for providing neuromodulation therapy are disclosed. The methods and systems are configured to sense an evoked neural response and use the evoked neural response as feedback for providing neuromodulation therapy. Methods of reducing stimulation artifacts that obscure the sensed evoked neural response are disclosed. The methods of artifact reduction include recording a stimulation artifact in the absence of an evoked neural response, aligning and scaling the stimulation artifact with respect to the obscured signal, and subtracting the aligned and scaled artifact from the obscured signal.
    Type: Grant
    Filed: January 13, 2022
    Date of Patent: June 4, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Rosana Esteller, Pranjali Borkar, Tianhe Zhang, Kiran K. Gururaj
  • Publication number: 20240139525
    Abstract: An example of a neurostimulation system may include a storage device for storing data representing physiological signals and a user interface including a user input, a display screen, and a presentation control circuit. The user input may be configured to receive a selection of signal(s) from the physiological signals and a selection of viewing mode from viewing modes including a metric mode and/or a presence mode. The metric mode allows for visualization of a signal property indicated by a parameter measured from the selected signal(s). The presence mode allows for viewing presence of a feature in the selected signal(s). The presentation control circuit may be configured to allow for the selection of the signal(s) and the viewing mode, to determine a segment of each of the selected signal(s) for presentation according to the selected viewing mode, and to present the determined segment on the display screen.
    Type: Application
    Filed: October 27, 2022
    Publication date: May 2, 2024
    Inventors: Tianhe Zhang, Rosana Esteller
  • Patent number: 11963779
    Abstract: An implantable device includes one or more electrodes to sense an electrical signal from a brain and a waveform analyzer to identify a half wave in the electrical signal; determine an amplitude and a duration of the half wave; determine if the amplitude satisfies a half wave amplitude criterion defined by a set of amplitude parameters comprising a minimum half wave amplitude and a maximum half wave amplitude; determine if the duration satisfies a half wave duration criterion defined by a set of duration parameters comprising a minimum half wave duration and a maximum half wave duration; and identify the half wave as a qualified half wave when the half wave amplitude criterion and the half wave duration criterion is satisfied. A neurological event may be detected based on one or more qualified half waves and electrical stimulation therapy may be delivered to the brain in response to the detection.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: April 23, 2024
    Assignee: NeuroPace, Inc.
    Inventor: Rosana Esteller
  • Publication number: 20240123234
    Abstract: An examples of a system for delivering neurostimulation to a patient may include a stimulation output circuit configured to deliver the neurostimulation, a sensing circuit configured to sense a neural signal indicative of neural responses to the neurostimulation, and stimulation control circuit. The stimulation control circuit may be configured to control the delivery of the neurostimulation using a plurality of stimulation parameters and may be configured to detect morphological features of the neural responses, to produce a neural response parameter using the detected morphological features, to detect a change in the sensed neural signal, to analyze the produced neural response parameter for attributing the detected change to one of a neural activation change in the patient or a body movement of the patient, and to control a dynamically controlled stimulation parameter of the plurality of stimulation parameters using the sensed neural signal and an outcome of the analysis.
    Type: Application
    Filed: October 13, 2023
    Publication date: April 18, 2024
    Inventors: Rosana Esteller, Max Witwer, Tianhe Zhang, Michael A. Moffitt
  • Patent number: 11944816
    Abstract: Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: April 2, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Que T. Doan, Jianwen Gu, Ismael Huertas Fernandez, Rosana Esteller, Michael A. Moffitt
  • Patent number: 11890465
    Abstract: Methods and systems for providing neuromodulation therapy are disclosed. The systems include an Implantable Pulse Generator (IPG) or External Trial Stimulator (ETS) that is capable of sensing an Evoked Compound Action Potential (ECAP), and (perhaps in conjunction with an external device) is capable of adjusting a stimulation program while based on the sensed ECAP. The stimulation program may include a pre-pulse component that may be adjusted based on the sensed ECAP. Moreover, stimulation may be applied to neural elements timed to coincide with the arrival of ECAPs at those neural elements. The stimulation may enhance or suppress activation of those neural elements.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: February 6, 2024
    Assignee: Boston Scientific Neuromodulation Corporation
    Inventors: Tianhe Zhang, Rosana Esteller, Natalie Brill
  • Publication number: 20240033525
    Abstract: Methods and systems for spinal cord stimulation (SCS) are disclosed. The methods and systems involve using electrode leads implanted within the patient's spinal column to record neural responses evoked by the stimulation. The disclosed neural responses are different in several respects from electrical responses that have previously been measured in the context of SCS, such as stimulation artifacts and evoked compound action potentials (ECAPs). The disclosed neural responses typically occur later in time following the evoking stimulation pulse. Another distinguishing feature is that disclosed neural responses are generally most prominently observed with consistent, relatively unchanging amplitudes when the evoking stimulation frequency is ultra-low, for example, about 10 Hz or less.
    Type: Application
    Filed: July 26, 2023
    Publication date: February 1, 2024
    Inventors: Tianhe Zhang, Rosana Esteller, Marom Bikson
  • Publication number: 20240033526
    Abstract: Methods and systems are described for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.
    Type: Application
    Filed: October 9, 2023
    Publication date: February 1, 2024
    Inventors: Rosana Esteller, Mahsa Malekmohammadi, Andrew Haddock, Tianhe Zhang