Abstract: The invention provides isolated nucleic acids molecules, designated 65552 nucleic acid molecules, which encode matrix metalloproteinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 65552 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 65552 gene has been introduced or disrupted. The invention still further provides isolated 65552 proteins, fusion proteins, antigenic peptides and anti-65552 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 58860 nucleic acid molecules, which encode cholesteryl ester hydrolases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 58860 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 58860 gene has been introduced or disrupted. The invention still further provides isolated 58860 proteins, fusion proteins, antigenic peptides and anti-58860 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 15985 nucleic acid molecules, which encode novel serine/threonine protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 15985 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 15985 gene has been introduced or disrupted. The invention still further provides isolated 15985 proteins, fusion proteins, antigenic peptides and anti-15985 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 32612 nucleic acid molecules, which encode a novel human peptide transporter protein. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 32612 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 32612 gene has been introduced or disrupted. The invention still further provides isolated 32612 proteins, fusion proteins, antigenic peptides and anti-32612 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 23565 nucleic acid molecules, which encode novel zinc carboxypeptidase members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 23565 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 23565 gene has been introduced or disrupted. The invention still further provides isolated 23565 proteins, fusion proteins, antigenic peptides and anti-23565 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 59079 and 12599 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 59079 or 12599 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 59079 or 12599 gene has been introduced or disrupted. The invention still further provides isolated 59079 and 12599 proteins, fusion proteins, antigenic peptides and anti-59079 and anti-12599 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 14089 nucleic acid molecules, which encode novel trypsin serine protease members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14089 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14089 gene has been introduced or disrupted. The invention still further provides isolated 14089 proteins, fusion proteins, antigenic peptides and anti-14089 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: Novel adenylate cyclase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length adenylate cyclase proteins, the invention further provides isolated adenylate cyclase fusion proteins, antigenic peptides, and anti-adenylate cyclase antibodies. The invention also provides adenylate cyclase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an adenylate cyclase gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 47174 nucleic acid molecules, which encode novel glycosyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47174 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47174 gene has been introduced or disrupted. The invention still further provides isolated 47174 proteins, fusion proteins, antigenic peptides and anti-47174 antibodies. Diagnostic methods utilizing compositions of the invention are also provided. The invention also provides methods of modulating pain or pain related disorders utilizing the compositions of the invention. Accordingly, methods of treating, preventing and/or diagnosing neurological disorders are disclosed.

Abstract: The invention provides isolated nucleic acids molecules, designated 84241 nucleic acid molecules, which encode novel RING finger members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 84241 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 84241 gene has been introduced or disrupted. The invention still further provides isolated 84241 proteins, fusion proteins, antigenic peptides and anti-84241 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 56739 nucleic acid molecules, which encode novel CUB family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 56739 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 56739 gene has been introduced or disrupted. The invention still further provides isolated 56739 proteins, fusion proteins, antigenic peptides and anti-56739 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 13245 nucleic acid molecules, which encode a novel myotonic dystrophy type protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13245 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 13245 gene has been introduced or disrupted. The invention still further provides isolated 13245 proteins, fusion proteins, antigenic peptides and anti-13245 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The present invention relates to a newly identified human carboxypeptidase. The invention also relates to polynucleotides encoding the carboxypeptidase. The invention further relates to methods using the carboxypeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in carboxypeptidase-related disorders. The invention further relates to drug-screening methods using the carboxypeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the carboxypeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the carboxypeptidase polypeptides and polynucleotides.

Abstract: The present invention relates to a newly identified human ubiquitin protease belonging to the family of mammalian deubiquitinating enzymes. The invention also relates to polynucleotides encoding the ubiquitin protease. The invention further relates to methods using the ubiquitin protease polypeptides and polynucleotides as a target for diagnosis and treatment in ubiquitin-mediated or -related disorders. The invention further relates to drug-screening methods using the ubiquitin protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ubiquitin protease polypeptides and polynucleotides. The invention further relates to procedures for producing the ubiquitin protease polypeptides and polynucleotides.

Abstract: The invention provides isolated nucleic acids molecules, designated HK nucleic acid molecules, which encode novel protein kinase family molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an HK gene has been introduced or disrupted. The invention still further provides isolated HK polypeptides, fusion polypeptides, antigenic peptides and anti-HK antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 69109 nucleic acid molecules, which encode a novel human protein tyrosine phosphatase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 69109 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 69109 gene has been introduced or disrupted. The invention still further provides isolated 69109 proteins, fusion proteins, antigenic peptides and anti-69109 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides isolated nucleic acids molecules, designated 55054 nucleic acid molecules, which encode a novel metalloproteinase/metallopeptidase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 55054 nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a 55054 gene has been introduced or disrupted. The invention still further provides isolated 55054 proteins, fusion proteins, antigenic peptides and anti-55054 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

Abstract: The invention provides an isolated nucleic acid molecule, designated as a kinase nucleic acid molecule, which encodes a novel protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing kinase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. The invention still further provides isolated 14790 proteins, fusion proteins, antigenic peptides and anti-kinase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The present invention relates to a newly identified human ubiquitin protease belonging to the family of mammalian deubiquitinating enzymes. The invention also relates to polynucleotides encoding the ubiquitin protease. The invention further relates to methods using the ubiquitin protease polypeptides and polynucleotides as a target for diagnosis and treatment in ubiquitin-mediated or -related disorders. The invention further relates to drug-screening methods using the ubiquitin protease polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the ubiquitin protease polypeptides and polynucleotides. The invention further relates to procedures for producing the ubiquitin protease polypeptides and polynucleotides.

Abstract: The invention provides isolated nucleic acid molecules, designated MAGK nucleic acid molecules, which encode novel guanylate kinase related molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MAGK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a MAGK gene has been introduced or disrupted. The invention still further provides isolated MAGK proteins, fusion proteins, antigenic peptides and anti-MAGK antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.