Patents by Inventor Rosemary Chang

Rosemary Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant BCG tuberculosis vaccine designed to elicit immune responses to mycobacterium tuberculosis in all physiological stages of infection and disease
    Patent number: 8361482
    Abstract: A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: January 29, 2013
    Assignee: Aeras Global TB Vaccine Foundation
    Inventors: Avigdor Shafferman, Anat Zvi, Naomi Ariel, John Fulkerson, Roaggai Sun, Rosemary Chang, Jerald C. Sadoff
  • Novel Recombinant BCG Tuberculosis Vaccine Designed to Elicit Immune Responses to Mycobacterium Tuberculosis in all Physiological Stages of Infection and Disease
    Publication number: 20110117133
    Abstract: A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
    Type: Application
    Filed: November 13, 2009
    Publication date: May 19, 2011
    Inventors: Avigdor Shafferman, Anat Zvi, Naomi Ariel, John Fulkerson, Roaggai Sun, Rosemary Chang, Jerald C. Sadoff
  • Recombinant BCG tuberculosis vaccine designed to elicit immune responses to in all physiological stages of infection and disease
    Patent number: 7670609
    Abstract: A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
    Type: Grant
    Filed: November 27, 2007
    Date of Patent: March 2, 2010
    Assignee: Aeras Global TB Vaccine Foundation
    Inventors: Avigdor Shafferman, Anat Zvi, Naomi Ariel, John Fulkerson, Ronggai Sun, Rosemary Chang, Jerald C. Sadoff
  • NOVEL RECOMBINANT BCG TUBERCULOSIS VACCINE DESIGNED TO ELICIT IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS IN ALL PHYSIOLOGICAL STAGES OF INFECTION AND DISEASE
    Publication number: 20090136534
    Abstract: A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
    Type: Application
    Filed: November 27, 2007
    Publication date: May 28, 2009
    Inventors: Avigdor Shafferman, Anat Zvi, Naomi Ariel, John Fulkerson, Ronggai Sun, Rosemary Chang, Jerald C. Sadoff