Patents by Inventor Rosevelt L. Pardy

Rosevelt L. Pardy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of detecting and quantifying endotoxins
    Publication number: 20040029104
    Abstract: The present invention relates to a method of detecting and quantifying a contaminant in a sample utilizing an insect based bioassay system. The method comprises exposing insect hemocytes, either in vivo or in vitro, to the sample to be tested followed by analyzing the cellular and biochemical behavior of the cells in the hemolymph subsequent to the exposure.
    Type: Application
    Filed: August 7, 2003
    Publication date: February 12, 2004
    Applicant: BOARD OF REGENTS OF UNIVERSITY OF NEBRASKA
    Inventors: David W. Stanley, Rosevelt L. Pardy
  • Isolated asgal lipopolysaccharides and use of same to inhibit innate immune response
    Patent number: 6444654
    Abstract: The isolation and purification of lipopolysaccharides from several related strains of eukaryotic algae is disclosed. These lipopolysaccharides have been shown to be structurally and functionally similar to the lipopolysaccharides of gram negative bacteria, or endotoxins, which have been shown to be a cause of sepsis or septic shock. The present invention also relates to the use of these algal lipopolysaccharides to inhibit the release of TNF-a from macrophages, which has been associated with the initiation and escalation of sepsis as a result of bacterial endotoxins. The present invention further relates to the use of these algal lipopolysaccharides to inhibit the innate immune system of insects and mammals.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: September 3, 2002
    Assignee: Board of Regents of University of Nebraska
    Inventor: Rosevelt L. Pardy
  • Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis
    Patent number: 6172220
    Abstract: The isolation and purification of lipopolysaccharides from several related strains of eukaryotic algae is disclosed. These lipopolysaccharides have been shown to be structurally and functionally similar to the lipopolysaccharides of gram negative bacteria, or endotoxins, which have been shown to be a cause of sepsis or septic shock. The present invention also relates to the use of these algal lipopolysaccharides to inhibit the release of TNF-a from macrophages, which has been associated with the initiation and escalation of sepsis as a result of bacterial endotoxins.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: January 9, 2001
    Assignee: Board of Regents of University of Nebraska
    Inventors: Rosevelt L. Pardy, Clare L. Royce