Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.

Abstract: The present invention relates to a heat resistant composition comprising polycarbonate and polyester, wherein said polyester comprises poly(ethylene terephthalate), that is substantially free of isophthalic acid moieties. The composition has a Vicat softening point, as determined by ISO-306 B120 at a load of 50N and a speed of 120° C./hr that is higher than the Vicat softening point of an otherwise identical composition wherein the poly(ethylene terephthalate) component contains isophthalic acid moieties. The present invention further relates to an article comprising or consisting of such a composition.

Abstract: Provided is a tape including a composition having a copolyester including polymeric units derived from ethylene glycol and terephthalic acid or a diester thereof and >0.50 and <5.00 wt % of polymeric units with regard to the total weight of the polyester derived from an oligomeric dihydroxy compound having a number average molecular weight of >500 g/mol and <5000 g/mol. Such tape has an improved tensile-impact strength and a reduced proneness to splitting during weaving.

Abstract: The present invention relates to a composition comprising from 25-75 wt. % of aromatic polycarbonate comprising melt polycarbonate and from 75-25 wt. % of polyester based on the combined weight of the aromatic polycarbonate and the polyester, wherein said polyester comprises poly(butylene terephthalate), and wherein said aromatic polycarbonate has an endcap level of at least 75 mol %. The present invention further relates to an article comprising or consisting of such a composition.

Abstract: The present invention relates to a composition comprising from 25-75 wt. % of aromatic polycarbonate comprising melt polycarbonate and from 75-25 wt. % of polyester based on the combined weight of the aromatic polycarbonate and the polyester, wherein said aromatic polycarbonate has an endcap level of at most 75 mol % and said polyester comprises polybutylene terephthalate, and wherein i) said polyester comprises a polymer miscible with poly(butylene terephthalate), said polymer having a glass transition temperature higher than the glass transition temperature of said poly(butylene terephthalate) and/or, ii) said aromatic polycarbonate comprises a polymer miscible with said melt polycarbonate, said polymer having a glass transition temperature higher than the glass transition temperature of said melt polycarbonate.

Abstract: The present invention relates to a composition comprising at least 60 wt. % aromatic polycarbonate and at most 40 wt. % of polyester comprising poly(butylene terephthalate), based on the combined amounts of aromatic polycarbonate and polyester, from 1-10 wt. % of impact modifier, based on the weight of the composition, wherein the composition comprises the aromatic polycarbonate and the polyester, the aromatic polycarbonate has an endcap level of at least 75 mol % and the aromatic polycarbonate comprises melt polycarbonate.

Abstract: Aspects of the present disclosure provide systems, methods, and computer-readable storage media that support automated optimization of product management systems. In embodiments, automated optimization of component tools of the product management system is provided by automated evaluation and optimization of associated rules and metadata. In embodiments, metadata and rules may be associated to each other by an assessment engine. A recommendation engine may then identify non-compliant metadata, may determine a condition of the rule, and/or may generate recommendations for the rules based on the non-compliant metadata. Automated optimization of the product management system may include automated creation and mapping of decomposition relationships between commercial products and technical products. In embodiments, input data may be parsed into a set of object with unique attribute fields, which may then be validated.

Abstract: A system includes an electric mobile application having a configurable charging circuit, the configurable charging circuit including an AC charging circuit couplable to a charging station on a first side, a DC charging circuit selectively couplable to a high voltage battery of the electric mobile application on a first side, and a switch interposed between the AC and DC charging circuits, where the switch provides selective coupling between the AC charging circuit on a second side and the DC charging circuit on a second side, where the switch in a first position couples the AC charging circuit to the DC charging circuit through a first inductive coupling arrangement utilizing a magnetic component, and where the switch in a second position couples the AC charging circuit to the DC charging circuit through a second inductive coupling arrangement utilizing the magnetic component.

Abstract: A method for preparing a modified polycarbonate comprising i) providing a polycarbonate prepared by the melt transesterification of a bisphenol and a diaryl carbonate preferably having a Fries branching level of from 750 to 2000 ppm, ii) combining said polycarbonate and from 0.10-0.75 wt. %, based on the amount of polycarbonate, of a modifier, iii) reacting said modifier and said polycarbonate in molten state at a temperature of from 250-300° C. and a reaction time of at least 30 seconds so as to form the modified polycarbonate, wherein said modifier is a styrene-(meth)acrylate copolymer containing glycidyl groups and having i) from 250 to 500 gram epoxy groups per mol and ii) a weight average molecular weight of from 3000 to 8500 g/mol, and wherein said modified polycarbonate has a transmittance of at least 85% and a haze of at most 5% as determined in accordance with ASTM D1003-13 on an injection moulded sheet having a thickness of 3 mm.

Abstract: The present invention relates to a tape comprising a composition comprising a copolyester comprising polymeric units derived from ethylene glycol and terephthalic acid or a diester thereof and >0.50 and <5.00 wt % of polymeric units with regard to the total weight of the polyester derived from an oligomeric dihydroxy compound having a number average molecular weight of >500 g/mol and <5000 g/mol. Such tape has an improved tensile-impact strength and a reduced proneness to splitting during weaving.

Abstract: The invention is directed to a composition comprising 90.00 to 99.95 wt % of a polyolefin and 0.05 to 10.00 weight % of an antimicrobial additive based on the total weight of the polyolefin composition wherein the antimicrobial additive comprises a phenolic group and wherein a carrier for the antimicrobial additive is present. The antimicrobial additive may be dispersed through the polyolefin composition. Preferred antimicrobial additives include for example eugenol, isoeugenol, thymol, carvacrol, sesamol, curcumin, p-hydroxybenzoic acid, gallic acid and its ester derivatives (propyl gallate, octyl gallate and dodecyl gallate), ferulic acid, syringic acid, coumaric acid, protocatechuic acid, caffeic acid and/or tannic acid.

Abstract: The present invention relates to a thermoplastic polyester copolymer comprising 50-1000 ppm with regard to the total weight of the thermoplastic polyester copolymer of moieties derived from an alcohol having ?3 hydroxy moieties. Such thermoplastic polyester copolymer allows for the production of high-quality foamed articles, whilst reducing the need for additives that are to be incorporated in the copolymer.

Abstract: Techniques for mapping from one or more source information sets to one or more target information sets are provided. Mapping ontologies associate a first declarative expression with a first information set from which to read first information, and a second declarative expression with a second information set to which second information determined based upon the read first information is written. A mapping graph having a nodes arranged according to an execution flow for obtaining the one or more target information sets is generated, at least some of these nodes representing respective ones of the mapping ontologies. The one or more target information sets are generated, each including information determined from the one or more source information sets, by traversing the mapping graph according to the execution flow. Each of the first and second declarative expressions may be associated with a mapping resolver for accessing one or more information sets.

Abstract: Embodiments herein described relate to methods for providing a user of an electronic marketplace with the option to add additional items to an order placed in the electronic marketplace, the additional items being either or both of physical goods under the control of the user, or goods under the control of a third party seller unassociated with the marketplace.

Abstract: The invention is directed to a composition comprising 90.00 to 99.95 wt % of a polyolefin and 0.05 to 10.00 weight % of an antimicrobial additive based on the total weight of the polyolefin composition wherein the antimicrobial additive comprises a phenolic group and wherein a carrier for the antimicrobial additive is present. The antimicrobial additive may be dispersed through the polyolefin composition. Preferred antimicrobial additives include for example eugenol, isoeugenol, thymol, carvacrol, sesamol, curcumin, p-hydroxybenzoic acid, gallic acid and its ester derivatives (propyl gallate, octyl gallate and dodecyl gallate), ferulic acid, syringic acid, coumaric acid, protocatechuic acid, caffeic acid and/or tannic acid.

Abstract: Techniques for mapping from one or more source information sets to one or more target information sets are provided. Mapping ontologies associate a first declarative expression with a first information set from which to read first information, and a second declarative expression with a second information set to which second information determined based upon the read first information is written. A mapping graph having a nodes arranged according to an execution flow for obtaining the one or more target information sets is generated, at least some of these nodes representing respective ones of the mapping ontologies. The one or more target information sets are generated, each including information determined from the one or more source information sets, by traversing the mapping graph according to the execution flow. Each of the first and second declarative expressions may be associated with a mapping resolver for accessing one or more information sets.

Abstract: The present disclosure provides an optical fiber cable. The optical fiber cable includes a buffer tube substantially present along a longitudinal axis. Further, the optical fiber cable includes a first layer. The first layer surrounds the buffer tube. Furthermore, the optical fiber cable includes a second layer. The second layer surrounds the first layer. Moreover, the optical fiber cable includes one or more strength members embedded inside the second layer. Further, the buffer tube encloses a plurality of optical fibers. Moreover, each of the plurality of optical fibers is color coded from a set of standard fiber colors and wherein the set of standard fiber colors comprises twelve colors. The first layer and the second layer provide a kink resistance, a crush resistance and flexibility to the optical fiber cable. Each of the one or more strength members is coated with a layer of ethylene acrylic acid.

Abstract: This invention relates to polymer particles for use in electrowetting fluids and electrowetting displays devices comprising such particles.

Abstract: This invention relates to electrowetting fluids, the use of these fluids for the preparation of an electrowetting displays devices, and electrowetting display devices comprising such fluids.

Abstract: A thermoplastic composition comprises: a compatibilized blend of a poly(arylene ether), an aliphatic-aromatic polyamide and a polymeric compatibilizer; and an impact modifier; wherein the aliphatic-aromatic polyamide is composed of units derived from a dicarboxylic acid and units derived from a diamine and the units derived from a dicarboxylic acid comprise 60 to 100 mol % of units derived from terephthalic acid and the units derived from a diamine comprise 60 to 100 mol % of units derived from 1,9-nonanediamine, 2-methyl-1,8-octanediamine, or a combination of 1,9-nonanediamine and 2-methyl-1,8-octanediamine.