Patents by Inventor Roshni SINGARAJA

Roshni SINGARAJA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT/PREVENTION OF DISEASE BY LINC COMPLEX INHIBITION
    Publication number: 20220370570
    Abstract: Methods for the treatment and prevention of laminopathies and diseases characterised by hyperlipidemia through LING complex inhibition are disclosed. In particular, LING complex disruption by expression of dominant-negative LING complex proteins alleviates pathophysiology in Lmna mutation-associated muscular dystrophy, progeria, and dilated cardiomyopathy. In addition, LING complex disruption by expression of dominant-negative LING complex proteins also alleviates pathophysiology in mouse models of atherosclerosis and familial hypercholesterolemia.
    Type: Application
    Filed: July 14, 2020
    Publication date: November 24, 2022
    Inventors: Colin Lawson STEWART, Roshni SINGARAJA, Brian BURKE, Yin Loon LEE, Yann Chong TAN