Abstract: A system and method are disclosed for a morphable pad and display configured for tactile control. The system comprises a display for displaying a user interface comprising a layout of vehicle control features. The display is configured to highlight a portion of the layout associated with a received highlight input, and to update the layout based on a received selection input. A morphable pad is connected to the display and comprises an array of switches. Each switch is configured to receive high-light input and selection input. The switches are also configured to adjust in tactile feel to match the layout, and to reconfigure in tactile feel responsive to a change in the layout.

Abstract: A portable microscope is provided comprising a body; a light source comprising a flash light for generating illumination, an objective lens having an optical axis, a stage for holding an object to be observed, and a mirror positioned along the objective optical axis on the other side of the objective lens, wherein the mirror reflects the illumination from the light source along the objective optical axis to an eyepiece. In some embodiments, the light source may be a fluorescent light source.

Abstract: Preparing the heart for connection with a ventricular assist device (VAD) can include attaching an attachment ring to a ventricular apex of the heart. The attachment ring optionally includes a seal or a valve to allow the procedure to be performed with or without a heart-lung bypass. A valve can be temporarily attached to the attachment ring. Tissue is removed from the ventricular apex through the attachment ring to form a hole through which an inflow conduit of the VAD can be inserted. A slit can first be made in the ventricular apex to facilitate removal of the tissue. A clamp can be closed around the attachment ring to secure the inflow conduit.

Abstract: An efficient process is disclosed for producing a compound that is an inhibitor of CETP. The last step of the process is the coupling of an oxazolidinone derivative with a biphenyl moiety to provide a compound of formula (I). In a specific embodiment of this synthesis, a crystalline product is produced which is characterized as a non-solvated crystalline polymorph.

Abstract: Processes for preparing certain N-arylalkyl-1-(alkyl or aralkyl)-2-acylaminoalkyl-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamides are disclosed. In one embodiment, the process comprises acylating the free amine in the corresponding N-arylalkyl-1-(alkyl or aralkyl)-2-aminoalkyl-5-ester protected hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide and then deprotecting the 5-hydroxy by base hydrolysis. The hydroxypyrimidinone carboxamide products of the process are HTV integrase inhibitors which are useful for treating HTV infection, treating AIDS, or delaying the onset or progression of AIDS. Certain esterified N-arylalkyl hydroxypyrimidinone carboxamides that can be employed as process intermediates are also disclosed.

Abstract: An efficient process is disclosed for producing a compound that is an inhibitor of CETP. The last step of the process is the coupling of an oxazolidinone derivative with a biphenyl moiety to provide a compound of formula (I). In a specific embodiment of this synthesis, a crystalline product is produced which is characterized as a non-solvated crystalline polymorph.

Abstract: A dental treatment planning system includes an input form to receive one or more dental patient inputs; and an engine adapted to receive the dental patient data from the input form and validating the dental patient data in a predetermined sequence.

Abstract: The present invention provides a manipulable or reconfigurable dental model system and methods for its use to model a series of tooth configurations corresponding to sequential tooth movements during an orthodontic treatment. When a patient undergoes orthodontic treatment, teeth and bite configurations are realigned in a series of stages. Each stage represents a new pattern or dental configuration that will eventually lead to a proper final positioning of the entire dentition. Progress from the initial configuration, through the intermediate stages and finally to the final configuration may be accomplished using any one or a combination of different dental appliances. Of particular interest to the present invention, many of these appliances may be made using a dental mold representing the patient's dental configuration. In particular, thermoformable plastic positioning appliances which fit over the patient's teeth may be formed over a three-dimensional mold of the patient's dentition.

Abstract: A system for repositioning teeth comprises a plurality of individual appliances used with braces. The appliances are configured to be placed successively on the patient's teeth and to incrementally reposition the teeth from an initial tooth arrangement, through a plurality of intermediate tooth arrangements, and to a final tooth arrangement. The appliances may be substituted with braces as appropriate to optimize the treatment of the teeth.

Abstract: A system for repositioning teeth comprises a plurality of individual appliances used with braces. The appliances are configured to be placed successively on the patient's teeth and to incrementally reposition the teeth from an initial tooth arrangement, through a plurality of intermediate tooth arrangements, and to a final tooth arrangement. The appliances may be substituted with braces as appropriate to optimize the treatment of the teeth.

Abstract: Traditional orthodontic treatment often involves the use of basic repositioning devices, such as braces, and the use of supplementary devices, components or accessories to achieve desired end results. Such components may be mounted on fixed, non-removable devices or they may be part of a removable appliance typically worn prior to the application of the fixed devices. As with traditional treatment, it may be desired to utilize similar components when repositioning teeth with removable elastic repositioning appliances. Due to the nature of elastic appliances, such components may take a variety of forms ranging from readily available traditional accessories to specially created devices. Thus, traditional components may be mounted on or embedded in an elastic appliance, or the appliance may be formed to provide similar components. Likewise, the appliance may be modified to provide additional features for specific orthodontic treatments.

Abstract: Traditional orthodontic treatment often involves the use of basic repositioning devices, such as braces, and the use of supplementary devices, components or accessories to achieve desired end results. Such components may be mounted on fixed, non-removable devices or they may be part of a removable appliance typically worn prior to the application of the fixed devices. As with traditional treatment, it may be desired to utilize similar components when repositioning teeth with removable elastic repositioning appliances. Due to the nature of elastic appliances, such components may take a variety of forms ranging from readily available traditional accessories to specially created devices. Thus, traditional components may be mounted on or embedded in an elastic appliance, or the appliance may be formed to provide similar components. Likewise, the appliance may be modified to provide additional features for specific orthodontic treatments.

Abstract: The present invention relates to the stereoselective preparation of 2,2-disubstituted-4-carbonatepyrroles from readily available chiral starting materials. Such pyrroles are useful as intermediates in the preparation of 2,2,4-trisubstituted 2,5-dihydropyrroles, that are inhibitors of mitotic kinesins and are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The product of the process of the invention may be illustrated by the Formula (I).

Abstract: Orthodontic treatment is achieved using a series of successive, removable repositioning appliances, such as thin polymeric shell appliances referred to as aligners. A set of aligners is originally provided to the patient. If the patient's treatment goes off course using the original set of aligners, further aligners are designed and fabricated to move the deviant tooth arrangement back to a target tooth arrangement which was part of the original treatment program.

Abstract: Systems and methods are disclosed that evaluate orthodontic care and treatment of a patient by receiving an orthodontic treatment plan, applying a clinical knowledge database that matches, at least approximately, the orthodontic condition of the patient; and generating a report for the treatment plan.

Abstract: A computer is used to create a plan for repositioning an orthodontic patient's teeth. The computer receives an initial digital data set representing the patient's teeth at their initial positions and a final digital data set representing the teeth at their final positions. The computer then uses the data sets to generate treatment paths along which the teeth will move from the initial positions to the final positions.

Abstract: A system for repositioning teeth comprises a plurality of individual appliances used with braces. The appliances are configured to be placed successively on the patient's teeth and to incrementally reposition the teeth from an initial tooth arrangement, through a plurality of intermediate tooth arrangements, and to a final tooth arrangement. The appliances may be substituted with braces as appropriate to optimize the treatment of the teeth.

Abstract: The present invention provides improved devices, systems and methods for repositioning teeth from an initial tooth arrangement to a final tooth arrangement. Repositioning is accomplished with a system comprising a series of polymeric shell appliances configured to receive the teeth and incrementally reposition individual teeth in a series of successive steps. The individual appliances may be formed from layers having different stiffnesses (elastic moduluses), and the stiffnesses of successive appliances may be different, or both.

Abstract: A system and method for managing an on board entertainment system is disclosed. The system and method can wirelessly receive music files from a computer and store those music files on an on board unit associated with a motor vehicle. The system and method can also include provisions to associate music information with a received music file and can include provisions to manage the music collection on board a motor vehicle.

Abstract: Orthodontic treatment is achieved using a series of successive, removable repositioning appliances, such as thin polymeric shell appliances referred to as aligners. A set of aligners is originally provided to the patient. If the patient's treatment goes off course using the original set of aligners, further aligners are designed and fabricated to move the deviant tooth arrangement back to a target tooth arrangement which was part of the original treatment program.