Abstract: The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.

Abstract: The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.

Abstract: The present invention relates to the discovery that signaling via a serotonin type 1B, 2, 4 and 6 receptor is important in T cell activation such that inhibiting such signaling can be used to modulate the immune response. This immunomodulation is useful for the treatment of immune diseases or conditions, and for the development of potential therapeutics for such diseases or conditions. It has been further discovered that, in cells proceeding through the cell cycle process, inhibition of serotonin signaling inhibits the process and induces apoptosis and morphological changes to a cell. These effects of inhibiting serotonergic signaling can be useful for effecting selective cell killing and for identifying compounds that inhibit the signaling.

Abstract: The present invention is directed toward a method and an apparatus for cutting material, such as paper and/or fabric, while simultaneously marking the material with a decorative border. The present invention utilizes an air pump and replaceable coloring means source affixed on a cutting apparatus, such as scissors, having an air pump and replaceable coloring dispenser along the blade(s) of the scissors. The pumping mechanism utilizes check valves to regulate the flow of air through the system. In another embodiment, a colorant may be used along the blade of the scissors wherein each cut leaves a decorative border along the cut area of the material.

Abstract: The present invention provides a toy doll for the amusement of a subject, that includes a torso, body, ahead and limbs, designed, sized and dimensioned for enabling the doll to be worn on the body of the subject in a position thereon sufficient for engaging in a “piggy back” and/or “horsey” style play. The child may engage the instant doll in such “piggy back” and/or “horse” style play, while in sitting, crawling and upright (or standing) play. The toy doll includes an electronic sound emanating module portions of which can be activated by releasably connecting one limb of the doll to another limb of the doll about the body of the subject. The doll includes a motion sensor including an averaging circuit for enabling substantially continuous sound such as galloping, while the doll is in motion. Optionally, the doll includes a tilt sensor for emanating a “neighing” sound when the longitudinal axis of the doll is tilted relative to the vertical axis.