Patents by Inventor Ross Cheloha

Ross Cheloha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered ligands and uses thereof
    Patent number: 11878063
    Abstract: Described herein are engineered ligand that binds a cell surface receptor (e.g., GPCR), with improved affinity, potency, and specificity. By conjugating a sub-optimal ligand for a cell surface receptor (e.g., GPCR) to a targeting molecule that binds an epitope (natural or exogenous epitope) in the extracellular portion of the cell surface receptor (e.g., GPCR), the affinity, potency, and/or specificity of the sub-optimal ligand is enhanced.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: January 23, 2024
    Assignees: Children's Medical Center Corporation, The General Hospital Corporation
    Inventors: Ross Cheloha, Hidde L. Ploegh, Thomas J. Gardella
  • ENGINEERED LIGANDS AND USES THEREOF
    Publication number: 20200316217
    Abstract: Described herein are engineered ligand that binds a cell surface receptor (e.g., GPCR), with improved affinity, potency, and specificity. By conjugating a sub-optimal ligand for a cell surface receptor (e.g., GPCR) to a targeting molecule that binds an epitope (natural or exogenous epitope) in the extracellular portion of the cell surface receptor (e.g., GPCR), the affinity, potency, and/or specificity of the sub-optimal ligand is enhanced.
    Type: Application
    Filed: March 5, 2020
    Publication date: October 8, 2020
    Applicants: Children's Medical Center Corporation, The General Hospital Corporation
    Inventors: Ross Cheloha, Hidde L. Ploegh, Thomas J. Gardella