Abstract: Surgical systems and methods for robotically-assisted insertion of a stem implant into a cavity of a bone. A manipulator includes a robotic arm that supports an end effector which detachably receives the stem implant. A navigation system includes a localizer to track poses of the bone and the end effector. Controller(s) coupled to the manipulator and the navigation system obtain a surgical plan defining a planned relationship between the stem implant and the bone. Based on the tracked poses and the surgical plan, the controller(s) control the manipulator to enable movement of the end effector and the stem implant to facilitate insertion of the stem implant into the cavity.

Abstract: Devices, systems, and methods for performing a transcorporeal microdecompression are described. The transcorporeal microdecompression may include a bone void plug allograft and specialized instruments for performing the procedure. This procedure may be performed under navigation and/or with robotic assistance.

Abstract: Surgical systems, methods and surgical planning programs to facilitate preparation of an anatomical cavity to receive a cup implant. The system includes a control system, a localizer and a robotic manipulator configured to move an energy applicator that is adapted to remove tissue. The control system obtains or generates a surgical plan that defines characteristics of cement holes to be formed within a wall of the anatomical cavity for receiving bone cement. The control system registers the surgical plan to the anatomical cavity with the localizer and controls the robotic manipulator to utilize the energy applicator to form the cement holes within the wall of the anatomical cavity according to the surgical plan.

Abstract: An ophthalmic imaging apparatus comprising: an illumination light source and an optical assembly for directing light from the light source into an eye of a subject; a photosensor array comprising a plurality of photosensors positioned for acquiring images of portions of a fundus of the eye; an objective lens positioned along an imaging axis intersecting a point on the fundus of the eye wherein the objective lens is positioned for refracting light that has been reflected by the fundus to form an image of the fundus on an image plane of the objective lens such that the image plane is positioned away from the photosensor array; and a microlens array comprising a plurality of microlenses wherein the microlens array is spaced away from and positioned behind the image plane and wherein the microlens array is positioned in between the image plane and the photosensor array such that each microlens in the array projects a different view of the image formed at the image plane thereby forming an array of elemental image

Abstract: Surgical systems, methods and surgical planning programs to facilitate preparation of an anatomical cavity to receive a cup implant. The system includes a control system, a localizer and a robotic manipulator configured to move an energy applicator that is adapted to remove tissue. The control system obtains or generates a surgical plan that defines characteristics of cement holes to be formed within a wall of the anatomical cavity for receiving bone cement. The control system registers the surgical plan to the anatomical cavity with the localizer and controls the robotic manipulator to utilize the energy applicator to form the cement holes within the wall of the anatomical cavity according to the surgical plan.

Abstract: An ophthalmic imaging apparatus comprising: an illumination light source and an optical assembly for directing light from the light source into an eye of a subject; a photosensor array comprising a plurality of photosensors positioned for acquiring images of portions of a fundus of the eye; an objective lens positioned along an imaging axis intersecting a point on the fundus of the eye wherein the objective lens is positioned for refracting light that has been reflected by the fundus to form an image of the fund us on an image plane of the objective lens such that the image plane is positioned away from the photosensor array; and a microlens array comprising a plurality of microlenses wherein the microlens array is spaced away from and positioned behind the image plane and wherein the microlens array is positioned in between the image plane and the photosensor array such that each microlens in the array projects a different view of the image formed at the image plane thereby forming an array of elemental imag

Abstract: An ophthalmic imaging apparatus comprising: an illumination light source and an optical assembly for directing light from the light source into an eye of a subject; a photosensor array comprising a plurality of photosensors positioned for acquiring images of portions of a fundus of the eye; an objective lens positioned along an imaging axis intersecting a point on the fundus of the eye wherein the objective lens is positioned for refracting light that has been reflected by the fundus to form an image of the fund us on an image plane of the objective lens such that the image plane is positioned away from the photosensor array; and a microlens array comprising a plurality of microlenses wherein the microlens array is spaced away from and positioned behind the image plane and wherein the microlens array is positioned in between the image plane and the photosensor array such that each microlens in the array projects a different view of the image formed at the image plane thereby forming an array of elemental imag

Abstract: There is provided an apparatus for providing an output signal to an audio transducer, comprising: a first signal path for receiving a first digital audio input signal, applying a first digital gain, and outputting an amplified first digital audio input signal; a second signal path, for receiving a second digital audio input signal, applying a second digital gain, and outputting an amplified second digital audio input signal; converter circuitry, coupled to the first and second signal paths, for converting at least the amplified first and second digital audio input signals into the analogue domain, and outputting an analogue audio input signal; and an analogue gain element, for applying an analogue gain to the analogue audio input signal and outputting the output signal.

Abstract: The present disclosure provides a system comprising: a) a modified RNA-binding protein (RBP) comprising: i) an RBP; and ii) one or more endosomolytic peptides (ELPs) covalently linked, directly or via a linker, to the RBP; and b) a modified cargo RNA complexed to the RBP, wherein the modified cargo RNA comprises a cargo RNA modified to include one or more RBP binding sites that are bound by the RBP present in the modified RBP. The present disclosure also provides a method of delivering a cargo RNA to a eukaryotic cell, the method comprising contacting the cell with the system of the present disclosure. The present disclosure provides methods of delivering a cargo RNA to the cytoplasm of a cell. The present disclosure provides methods of delivering a cargo RNA to the cytosol of a cell.

Abstract: Methods and systems are provided for robotic assisted surgery. A robotic system includes a localizer, a surgical robotic manipulator, an end effector configured to be removably coupled to the manipulator, and a controller. The controller is configured to receive signals from the localizer, determine a final position of a cavity creation tool used to penetrate a portion of a patient's anatomy based on the signals received from the localizer, and determine an implant insertion path for an implant to be inserted into a final implant position within the portion of the patient's anatomy, wherein the final implant position corresponds to the final position of the cavity creation tool. The controller is also configured to move the end effector with the implant coupled thereto such that the implant moves along the implant insertion path, and terminate the movement of the end effector when the implant reaches the final implant position.

Abstract: There is provided an apparatus for providing an output signal to an audio transducer, comprising: a first signal path for receiving a first digital audio input signal, applying a first digital gain, and outputting an amplified first digital audio input signal; a second signal path, for receiving a second digital audio input signal, applying a second digital gain, and outputting an amplified second digital audio input signal; converter circuitry, coupled to the first and second signal paths, for converting at least the amplified first and second digital audio input signals into the analogue domain, and outputting an analogue audio input signal; and an analogue gain element, for applying an analogue gain to the analogue audio input signal and outputting the output signal.

Abstract: An ophthalmic imaging apparatus comprising: an illumination light source and an optical assembly for directing light from the light source into an eye of a subject; a photosensor array comprising a plurality of photosensors positioned for acquiring images of portions of a fundus of the eye; an objective lens positioned along an imaging axis intersecting a point on the fundus of the eye wherein the objective lens is positioned for refracting light that has been reflected by the fundus to form an image of the fund us on an image plane of the objective lens such that the image plane is positioned away from the photosensor array; and a microlens array comprising a plurality of microlenses wherein the microlens array is spaced away from and positioned behind the image plane and wherein the microlens array is positioned in between the image plane and the photosensor array such that each microlens in the array projects a different view of the image formed at the image plane thereby forming an array of elemental imag

Abstract: There is provided an apparatus for providing an output signal to an audio transducer, comprising: a first signal path for receiving a first digital audio input signal, applying a first digital gain, and outputting an amplified first digital audio input signal; a second signal path, for receiving a second digital audio input signal, applying a second digital gain, and outputting an amplified second digital audio input signal; converter circuitry, coupled to the first and second signal paths, for converting at least the amplified first and second digital audio input signals into the analogue domain, and outputting an analogue audio input signal; and an analogue gain element, for applying an analogue gain to the analogue audio input signal and outputting the output signal.

Abstract: Methods and systems are provided for robotic assisted surgery. A robotic system includes a localizer, a surgical robotic manipulator, an end effector configured to be removably coupled to the manipulator, and a controller. The controller is configured to receive signals from the localizer, determine a final position of a cavity creation tool used to penetrate a portion of a patient's anatomy based on the signals received from the localizer, and determine an implant insertion path for an implant to be inserted into a final implant position within the portion of the patient's anatomy, wherein the final implant position corresponds to the final position of the cavity creation tool. The controller is also configured to move the end effector with the implant coupled thereto such that the implant moves along the implant insertion path, and terminate the movement of the end effector when the implant reaches the final implant position.

Abstract: There is provided an apparatus for providing an output signal to an audio transducer, comprising: a first signal path for receiving a first digital audio input signal, applying a first digital gain, and outputting an amplified first digital audio input signal; a second signal path, for receiving a second digital audio input signal, applying a second digital gain, and outputting an amplified second digital audio input signal; converter circuitry, coupled to the first and second signal paths, for converting at least the amplified first and second digital audio input signals into the analogue domain, and outputting an analogue audio input signal; and an analogue gain element, for applying an analogue gain to the analogue audio input signal and outputting the output signal.

Abstract: Computer implemented methods and systems for generating a brand site for an internet website is provided. The method includes defining the internet website to include a plurality of modules, and each of the plurality of modules for the internet website being directed toward a brand. Further included, is identifying one or more instance sites where content components related to the brand are presented and linking the content components, from the identified one or more instance sites, to selected ones of the plurality of modules. The method further includes presenting the plurality of modules on the internet website to promote the brand, and the presenting is configured to integrate the content components from the instance sites into the internet website, such that the presenting further enables user interactivity with the plurality of modules and the user interactivity feeds data regarding one or more of module popularity, usage or revenue generating potential.

Abstract: Computer implemented methods and systems for generating a brand site for an internet website is provided. The method includes defining the internet website to include a plurality of modules, and each of the plurality of modules for the internet website being directed toward a brand. Further included, is identifying one or more instance sites where content components related to the brand are presented and linking the content components, from the identified one or more instance sites, to selected ones of the plurality of modules. The method further includes presenting the plurality of modules on the internet website to promote the brand, and the presenting is configured to integrate the content components from the instance sites into the internet website, such that the presenting further enables user interactivity with the plurality of modules and the user interactivity feeds data regarding one or more of module popularity, usage or revenue generating potential.

Abstract: A drinking device for use with a container of potable liquid having a vessel portion for holding liquid and an attachment structure for attaching the device to the container of potable liquid is provided. In one embodiment, the device includes an illuminator to provide illumination to the device. In another embodiment, the device includes a sound generator to produce sound from the device. The device can also include both the illuminator and the sound generator.

Abstract: A process of dying a seat belt within a dye range, the seat belt comprising a woven polyester material containing a blended hybrid fiber of the type known as PET-polycaprolactone diblock copolymer fiber, the process comprising the steps of: heating the webbing to a preferred range while under tension and subsequently washing, steaming, finish coating and drying the webbing.