Patents by Inventor Ross D. Jones

Ross D. Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200291428
    Abstract: Provided herein are engineered HSV-1 vectors comprising a modified HSV-1 genome. The engineered HSV-1 vectors can be used to deliver genetic circuits (e.g., up to 100 kb) to cells in vitro or in vivo. Methods of treating or diagnosing a disease (e.g., cancer) using the engineered HSV-1 vectors described herein are also provided.
    Type: Application
    Filed: January 14, 2020
    Publication date: September 17, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Maria Hottelet Foley, Jin Huh, Ross D. Jones
  • Publication number: 20200056189
    Abstract: Provided herein are genetic circuits and cell state classifiers for detecting the microRNA profile of a cell. The cell state classifiers of the present disclosure utilize phosphorylation state of a transcription factor to control classifier output. Kinases and phosphatase pairs that function in phosphorylating or dephosphorylating the transcription factor are integrated into the circuit, their expression tuned by the presence of microRNAs of interest (e.g., in a cell). The genetic circuits and cell state classifiers may be used in various applications (e.g., therapeutic or diagnostic applications).
    Type: Application
    Filed: August 1, 2019
    Publication date: February 20, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Ross D. Jones, Jin Huh