Abstract: A method for the manufacture of an improved graphene substrate and applications therefor There is provided a method (100) for the manufacture of an electronic device precursor, the method comprising: (i) providing a silicon wafer (200) having a growth surface (205); (ii) forming (105) an insulative layer (210) on the growth surface (205) having a thickness of from 1 nm to 10 nm, preferably 2 nm to 1 nm; (iii) forming (110) a graphene monolayer or multi-layer structure (215) on the insulative layer (210); (iv) optionally forming (115, 120) one or more further layers (220) and/or electrical contacts (225, 230) on the graphene monolayer or multi-layer structure (215); (v) forming (125) a polymer coating (235) over the graphene monolayer or multi-layer structure (215) and any further layers (115) and/or electrical contacts (225, 230); (vi) thinning (130) the silicon wafer (200), or removing the silicon wafer (200) to provide an exposed surface of the insulative layer (210), by etching with an etchant, wherein the

Abstract: A seal includes: a seal ring, having at least one dynamically stressed seal lip; a supporting ring made of a toughened material; and a connecting device made of an elastomeric material. The seal ring and the supporting ring are connected to one another. The supporting ring includes a radial leg, to which, in a radial direction, the seal lip is fixed. The radial leg is formed of two parts and, in the radial direction, has arranged a first partial leg and, in an other radial direction has arranged a second partial leg. The partial legs are associated adjacent with a first radial distance and delineate a first gap. The first partial leg is connected with the seal lip. The first and the second partial legs are fixed to one another by the connecting device. The connecting device, when viewed in cross section, has an axial length and a radial height.

Abstract: In an embodiment, the present invention provides a sealing arrangement for sealing two chambers that are adjacent to one another in an axial direction and are to be sealed with respect to one another, including: a first machine element; a second machine element, the second machine element surrounding the first machine element with a radial spacing therebetween, the sealing ring being arranged in the gap formed by the radial spacing; and a sealing ring, the sealing ring including at least one dynamically loaded first sealing lip, which sealingly surrounds a surface to be sealed of the first machine element, the sealing ring being arranged in an installation chamber of the second machine element and the sealing ring comprising a first and a second end face, the first end face axially facing the first chamber to be sealed and the second end face axially facing the second chamber to be sealed.

Abstract: A seal includes: a seal ring, having at least one dynamically stressed seal lip; a supporting ring made of a toughened material; and a connecting device made of an elastomeric material. The seal ring and the supporting ring are connected to one another. The supporting ring includes a radial leg, to which, in a radial direction, the seal lip is fixed. The radial leg is formed of two parts and, in the radial direction, has arranged a first partial leg and, in an other radial direction has arranged a second partial leg. The partial legs are associated adjacent with a first radial distance and delineate a first gap. The first partial leg is connected with the seal lip. The first and the second partial legs are fixed to one another by the connecting device. The connecting device, when viewed in cross section, has an axial length and a radial height.

Abstract: In an embodiment, the present invention provides a sealing arrangement for sealing two chambers that are adjacent to one another in an axial direction and are to be sealed with respect to one another, including: a first machine element; a second machine element, the second machine element surrounding the first machine element with a radial spacing therebetween, the sealing ring being arranged in the gap formed by the radial spacing; and a sealing ring, the sealing ring including at least one dynamically loaded first sealing lip, which sealingly surrounds a surface to be sealed of the first machine element, the sealing ring being arranged in an installation chamber of the second machine element and the sealing ring comprising a first and a second end face, the first end face axially facing the first chamber to be sealed and the second end face axially facing the second chamber to be sealed.

Abstract: A gasket, which is configured as a single block (1), includes a guide ring (2) made of a tough material, at least one dynamically loaded sealing lip (3, 4) and at least one statically loaded sealing lip (5), wherein the dynamically loaded sealing lip (3, 4) and the statically loaded sealing lip (5) are formed of a rubber elastic material and are connected with the guide ring (2), wherein at least one first (3) and one second dynamically loaded sealing lip (4) are connected with the guide ring (2), wherein the first dynamically loaded sealing lip (3) is configured for sealing a medium (6) from a space (7) to be sealed and the second dynamically loaded sealing lip (4) is configured for sealing out contaminants (8) from the surrounding environment (9), and wherein the first sealing lip (3) is placed behind the second sealing lip (4), viewed from the surrounding environment (9) in the direction of the space (7) to be sealed off.

Abstract: A pre-packaged food or beverage product is provided which includes macronutrients in the form of protein, carbohydrate and fat, wherein each complete serving of the product has the same relative proportions of the NRV for each macronutrient, and wherein the fibre content in the serving provides a proportion of the NRV that is at least 5% greater than the proportions of the NRV provided by the fat, protein or carbohydrate in a serving.

Abstract: A pre-packaged food or beverage product is provided in which each complete serving of the product includes at least two macronutrients selected from protein, fat, or carbohydrates wherein each selected macronutrient is in an amount which provides the same relative proportion of the NRV as the selected other macronutrient, but wherein the third macronutrient is not present in the same relative proportion as the two selected macronutrients, and wherein each complete serving of the product also includes fibre in the same relative proportions of the NRV as the two selected macronutrients.

Abstract: This invention relates to kits, compositions, and formulations comprising AICA riboside and analogs thereof and methods of using the same. The kits may comprise the compositions and/or formulations within a pH range, in a sterilized form. The kits may further comprise containers with a second therapeutic agent. The kits and compositions herein can be used to prevent morbidity/mortality in a patient or to prevent/treat an ischemic condition, a condition regulated by adenosine, or a condition associated with reduced blood flow to a tissue in a patient.

Abstract: Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.

Abstract: Intestine-specific delivery of an opioid antagonist can be accomplished without substantial central nervous system effects by administering the antagonist orally in the form of the glucuronide derivative.

Abstract: The preparation of antigens and their selective antibodies for antipyrine therefrom as well as an immunoassay for antipyrine using said antibodies is described. Such radioimmunoassay can be utilized to determine an individual's antipyrine half-life which has been correlated with the genetically controlled level of benzo[a]pyrene hydroxylase induction. The latter measurement has been associated with risk to bronchogenic carcinoma. Thus determination of the antipyrine half-life by means of the instant radioimmunoassay can be used as a screening test for identifying individuals at special risk to lung cancer.