Patents by Inventor Ross J. Whittaker

Ross J. Whittaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10928308
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths. The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials, calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: February 23, 2021
    Assignee: Vala Sciences, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Publication number: 20190353586
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths. The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials, calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Application
    Filed: July 15, 2019
    Publication date: November 21, 2019
    Applicant: Vala Sciences, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Patent number: 10359357
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths. The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials, calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: July 23, 2019
    Assignee: Vala Sciences, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Publication number: 20180299371
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths. The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials, calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 18, 2018
    Applicant: Vala Sciences, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Patent number: 9939372
    Abstract: Video recordings from two or more optical channels are produced, processed, and analyzed simultaneously in order to provide quantitative analysis of action potentials, calcium transients and ionic flux in excitable cells loaded with voltage or ion sensitive dyes with distinct excitation and emission wavelengths, The specific wavelengths of fluorescent light emitted from each dye are separated and recorded. The recordings are mutually registered and cytometric analysis is performed to provide a quantitative analysis of the action potentials calcium transient, and/or ionic flux on a cell-by-cell and well-by-well basis in microtiter plates. The cells are then fixed, labeled for other biomarkers, and scanned again. The resulting fixed cell images are registered with the live cell recordings and analyzed; missing cells that were washed off are detected relative to the live recordings, and cytometry data from live and fixed cell scans is collated cell-by-cell.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: April 10, 2018
    Assignee: Vala Science, Inc.
    Inventors: Fabio Cerignoli, Piyush Gehalot, Patrick M. McDonough, Jeffrey H. Price, Ross J. Whittaker
  • Publication number: 20120124684
    Abstract: The invention provides a modified version of alpha B-Crystallin (?BC), and methods for delivering this modified version of alpha B-Crystallin (?BC) to tissues and cells; the invention provides a modified version of ?BC in which the serine at position 59 has been changed to glutamate to mimic phosphorylation and the serine at positions 19 and 45 have been changed to alanine to prevent phosphorylation of those residues. The invention also provides compositions and methods for ameliorating a cell from ischemia/reperfusion injury or protecting a cell from ischemia/reperfusion injury.
    Type: Application
    Filed: December 1, 2009
    Publication date: May 17, 2012
    Applicant: SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION
    Inventors: Christopher C. Glembotski, Ross J. Whittaker