Abstract: An auto-injector may include a container capable of comprising a medicament; a shuttle coupled to the container and on a horizontal path with a first state and a second state; an energy source configured to release energy to translate the container and to translate the shuttle, preferably the energy source is pressurized fluid from a can; an impediment preventing horizontal movement of the shuttle before activation of the auto-injector; and a needle having a first end configured to extend out of the auto-injector, and a second end configured to extend into the container, wherein the second end of the needle and the container are not in fluid communication with one another before activation of the auto-injector.

Abstract: Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

Abstract: Disclosed herein are devices and methods for generating and/or verifying a predictive temperature stress and time creep modulus, approving or rejecting a medical device, verifying a medical device design using a linear device model, and generating coefficients using thermal analysis.

Abstract: A method of developing a predictive model may include identifying mixing protocol parameters for the predictive model, identifying an evaluation criterion for the predictive model, selecting test values for the mixing protocol parameters, identifying a computational fluid dynamics (CFD) simulation required to be performed in order to generate the evaluation criteria, conducting the CFD simulation for each combination of test values, thereby generating evaluation criteria corresponding to each combination of test values, generating a domain of potential predictive models relating the mixing protocol parameters to the evaluation criterion, identifying a pool of candidate predictive models from the domain of potential predictive models, and ranking the pool of candidate predictive models.

Abstract: An auto-injector may include a container capable of comprising a medicament; a shuttle coupled to the container and on a horizontal path with a first state and a second state; an energy source configured to release energy to translate the container and to translate the shuttle, preferably the energy source is pressurized fluid from a can; an impediment preventing horizontal movement of the shuttle before activation of the auto-injector; and a needle having a first end configured to extend out of the auto-injector, and a second end configured to extend into the container, wherein the second end of the needle and the container are not in fluid communication with one another before activation of the auto-injector.

Abstract: An auto-injector may include a housing having a longitudinal axis and a transverse axis, the housing having a shorter dimension along the transverse axis than along the longitudinal axis, wherein the transverse axis is perpendicular to the longitudinal axis; a flowpath having a first end and a second end; and a container enclosing a first fluid, the container extending from a first end toward a second end along or parallel to the longitudinal axis and being movable from a first position to a second position along or parallel to the longitudinal axis, the container being fluidly isolated from the flowpath in the first position and fluidly connected to the flowpath in the second position.

Abstract: Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

Abstract: An auto-injector may include a housing having a longitudinal axis and a transverse axis, the housing having a shorter dimension along the transverse axis than along the longitudinal axis, wherein the transverse axis is perpendicular to the longitudinal axis; a flowpath having a first end and a second end; and a container enclosing a first fluid, the container extending from a first end toward a second end along or parallel to the longitudinal axis and being movable from a first position to a second position along or parallel to the longitudinal axis, the container being fluidly isolated from the flowpath in the first position and fluidly connected to the flowpath in the second position.

Abstract: According to one aspect of the disclosure, an apparatus for manipulating a sclera to facilitate delivery of a medicament to a suprachoroidal space of an eye may include a needle with a sharp distalmost tip, a needle hub connected to a proximal end of the needle, a housing surrounding the needle hub and extending from a proximal end of the needle hub, and an adaptor surrounding a portion of the needle.

Abstract: A pulse detonation combustor includes at least one plenum located along the length of the pulse detonation combustor. The plenum can be located: 1) proximate an air valve; 2) between a fuel injection port and an ignition source; 3) downstream of both the fuel injection port and the ignition source; and 4) proximate an exit nozzle of the pulse detonation combustor. In addition, the pulse detonation combustor can have multiple plenums, for example, proximate the air valve and proximate the exit nozzle. The location and dimensions of the plenum can be selectively adjusted to control mechanical loading on the wall, the velocity of fluid flowing within the combustor, and the pressure generated by the pulse detonation combustor.

Abstract: A system for efficiently creating cyclic detonations is provided. The system includes at least a first initiator chamber configured to generate an initial wave, at least one main chamber coupled to the first initiator chamber. The main chamber is configured to generate a main wave and to output products of supersonic combustion. The products are generated within the main chamber. The main chamber is configured to enable the main wave to travel upstream and downstream within the main chamber when the first initiator chamber is located outside the main chamber. The system further includes an initial connection section located between the first initiator chamber and the main chamber that enhances a combustion process via shock focusing and shock reflection.