Patents by Inventor Ross L. Stein

Ross L. Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 7531526
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: January 2, 2008
    Date of Patent: May 12, 2009
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Boronic ester and acid compounds, synthesis and uses
    Publication number: 20080132678
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: January 2, 2008
    Publication date: June 5, 2008
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Boronic ester and acid compounds, synthesis and uses
    Patent number: 7119080
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: October 10, 2006
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Method for monitoring proteasome inhibitor drug action
    Patent number: 6613541
    Abstract: The invention relates to methods for measuring proteasome activity in biological samples. More particularly, then invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: September 2, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Gopalakrishna R. Vaddi, Ross L. Stein, Lawrence R. Dick, Vito J. Palombella, Eric S. Lightcap, Peter J. Elliott, Julian Adams, Teresa A. McCormack, Stephen J. Brand, Dan R. Burns
  • Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein
    Patent number: 5693617
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain proteasome inhibitors. The structure of the inhibitors are also disclosed.
    Type: Grant
    Filed: January 15, 1995
    Date of Patent: December 2, 1997
    Assignee: ProScript, Inc.
    Inventors: Ross L. Stein, Yu-Ting Ma, Stephen Brand
  • Therapeutic agent for the prevention or treatment of adult respiratory distress syndrome
    Patent number: 5338727
    Abstract: There is provided a novel therapeutic agent for use in the prevention or treatment of adult respiratory distress syndrome and for use in the manufacture of a medicament for the prevention or treatment of adult respiratory distress syndrome, as well as a method of prevention or treatment of adult respiratory distress syndrome with the therapeutic agent and a method of treatment of cystic fibrosis with the therapeutic agent in combination with one or more other agents indicated for the treatment of adult respiratory distress syndrome.
    Type: Grant
    Filed: August 3, 1992
    Date of Patent: August 16, 1994
    Assignee: Imperial Chemical Industries PLC
    Inventors: Mitchell Glass, Joseph C. Williams, Ross L. Stein
  • Proline derivatives
    Patent number: 4691007
    Abstract: Proline derivatives of the formulae: ##STR1## wherein R.sup.1 through R.sup.11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.
    Type: Grant
    Filed: December 6, 1985
    Date of Patent: September 1, 1987
    Assignees: ICI Americas Inc., Imperial Chemical Industries PLC
    Inventors: Anand S. Dutta, Ross L. Stein, Diane A. Trainor, Richard A. Wildonger
  • Proline derivatives
    Patent number: 4596789
    Abstract: Proline derivatives of the formulae: ##STR1## wherein R.sup.1 through R.sup.11 have defined values, and acid- and base-addition salts thereof, and equilibrium addition compounds of the aldehyde group thereof; processes for their preparation; pharmaceutical compositions; and intermediates for preparing said proline derivatives. The proline derivatives are human leukocyte elastase inhibitors which are useful, for example, in treating pulmonary emphysema.
    Type: Grant
    Filed: April 24, 1984
    Date of Patent: June 24, 1986
    Assignees: ICI Americas Inc., Imperial Chemical Industries PLC
    Inventors: Anand S. Dutta, Ross L. Stein, Diane A. Trainor, Richard A. Wildonger