Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.

Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.

Abstract: A method having steps of placing a glass sheet having a front surface, a reverse surface and a thickness onto a sacrificial substrate; directing a beam from a laser at the front surface and through the glass sheet; pulsing the beam at a frequency of between 10 kHz and 30 kHz, and at the sacrificial substrate; moving the beam across the glass sheet at a rate of between 30 millimeters per second and 90 millimeters per second; ablating the sacrificial substrate with the beam; generating a superheated vapor in response to the ablating of the sacrificial substrate; and ablating the reverse surface of the glass sheet with the superheated vapor, whereby the glass sheet is cut.

Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.

Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.

Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.

Abstract: A method having steps of placing a glass sheet having a front surface, a reverse surface and a thickness onto a sacrificial substrate; directing a beam from a laser at the front surface and through the glass sheet; pulsing the beam at a frequency of between 10 kHz and 30 kHz, and at the sacrificial substrate; moving the beam across the glass sheet at a rate of between 30 millimeters per second and 90 millimeters per second; ablating the sacrificial substrate with the beam; generating a superheated vapor in response to the ablating of the sacrificial substrate; and ablating the reverse surface of the glass sheet with the superheated vapor, whereby the glass sheet is cut.

Abstract: An implantable device for reversing an overdose of a substance in a person. The device measures the person's respiratory rate and/or the person's activity state and automatically injects a dose of overdose reversal agent in the person if the person's respiratory rate and/or the person's activity state indicate that the person may over overdosed on the substance. The device can administer subsequent doses if the person's respiratory rate and/or the person's activity state continue have not improved after the first dose. The device can include a wireless communication device to contact a third party after one or more doses have been administered.

Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.

Abstract: There is accordingly provided an exercise apparatus including an inner housing upon which a user may stand. The apparatus includes an outer housing rotatably coupled to the inner housing. The apparatus includes a handlebar coupled to and extending upwards from the outer housing. The apparatus includes a mount for retaining one or more weights thereon. The mount operatively connects to the outer housing and is enclosed within one of the housings.

Abstract: There is accordingly provided an exercise apparatus including an inner housing upon which a user may stand. The apparatus includes an outer housing rotatably coupled to the inner housing. The apparatus includes a handlebar coupled to and extending upwards from the outer housing. The apparatus includes a mount for retaining one or more weights thereon. The mount operatively connects to the outer housing and is enclosed within one of the housings.

Abstract: A capacitor warning circuit, and method of providing a warning are provided, the circuit comprising a capacitor capable of being charged to a charged state and a warning circuit coupled to the capacitor and adapted to provide an indication that the capacitor is in the charged state, wherein the warning circuit is powered by energy accumulated in the capacitor when the capacitor is in the charged state.

Abstract: A capacitor warning circuit, and method of providing a warning are provided, the circuit comprising a capacitor capable of being charged to a charged state and a warning circuit coupled to the capacitor and adapted to provide an indication that the capacitor is in the charged state, wherein the warning circuit is powered by energy accumulated in the capacitor when the capacitor is in the charged state.

Abstract: The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein.