Patents by Inventor Ross MACDONALD
Ross MACDONALD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250145712Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.Type: ApplicationFiled: October 15, 2024Publication date: May 8, 2025Applicant: Bristol-Myers Squibb CompanyInventors: Jason Samuel SIMON, Petra B. ROSS-MACDONALD
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Patent number: 12152075Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.Type: GrantFiled: July 9, 2021Date of Patent: November 26, 2024Assignee: Bristol-Myers Squibb CompanyInventors: Jason Samuel Simon, Petra B. Ross-Macdonald
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Publication number: 20220002413Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.Type: ApplicationFiled: July 9, 2021Publication date: January 6, 2022Applicant: Bristol-Myers Squibb CompanyInventors: Jason Samuel SIMON, Petra B. ROSS-MACDONALD
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Patent number: 11078278Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.Type: GrantFiled: May 27, 2016Date of Patent: August 3, 2021Assignee: Bristol-Myers Squibb CompanyInventors: Jason Samuel Simon, Petra B. Ross-Macdonald
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Patent number: 10919794Abstract: A method having steps of placing a glass sheet having a front surface, a reverse surface and a thickness onto a sacrificial substrate; directing a beam from a laser at the front surface and through the glass sheet; pulsing the beam at a frequency of between 10 kHz and 30 kHz, and at the sacrificial substrate; moving the beam across the glass sheet at a rate of between 30 millimeters per second and 90 millimeters per second; ablating the sacrificial substrate with the beam; generating a superheated vapor in response to the ablating of the sacrificial substrate; and ablating the reverse surface of the glass sheet with the superheated vapor, whereby the glass sheet is cut.Type: GrantFiled: December 4, 2017Date of Patent: February 16, 2021Assignee: GENERAL ATOMICSInventors: James Ross MacDonald, Esteban Balarezo Bagdy, Mark Aoraha Cacause, Jeffrey James Trial
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Publication number: 20200161054Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.Type: ApplicationFiled: January 22, 2020Publication date: May 21, 2020Inventors: James Ross MacDonald, Esteban Balarezo Bagdy, Mark Aoraha Cacause, Mark Allen Schneider
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Patent number: 10586654Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.Type: GrantFiled: December 21, 2017Date of Patent: March 10, 2020Assignee: GENERAL ATOMICSInventors: James Ross MacDonald, Esteban Balarezo Bagdy, Mark Aoraha Cacause, Mark Allen Schneider
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Publication number: 20190198247Abstract: A method for making a glass dielectric capacitor may include providing a plurality of foil sheets, cutting each of the plurality of foil sheets with a laser beam by melting each of the plurality of foil sheets, forming a respective smooth foil edge on each of said plurality of foil sheets during the cutting, providing a plurality of glass sheets, and stacking the plurality of foil sheets in alternating layers with the plurality of glass sheets.Type: ApplicationFiled: December 21, 2017Publication date: June 27, 2019Inventors: James Ross MacDonald, Esteban Balarezo Bagdy, Mark Aoraha Cacause, Mark Allen Schneider
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Publication number: 20190169062Abstract: A method having steps of placing a glass sheet having a front surface, a reverse surface and a thickness onto a sacrificial substrate; directing a beam from a laser at the front surface and through the glass sheet; pulsing the beam at a frequency of between 10 kHz and 30 kHz, and at the sacrificial substrate; moving the beam across the glass sheet at a rate of between 30 millimeters per second and 90 millimeters per second; ablating the sacrificial substrate with the beam; generating a superheated vapor in response to the ablating of the sacrificial substrate; and ablating the reverse surface of the glass sheet with the superheated vapor, whereby the glass sheet is cut.Type: ApplicationFiled: December 4, 2017Publication date: June 6, 2019Inventors: James Ross MacDonald, Esteban Balarezo Bagdy, Mark Aoraha Cacause, Jeffrey James Trial
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Publication number: 20180228969Abstract: An implantable device for reversing an overdose of a substance in a person. The device measures the person's respiratory rate and/or the person's activity state and automatically injects a dose of overdose reversal agent in the person if the person's respiratory rate and/or the person's activity state indicate that the person may over overdosed on the substance. The device can administer subsequent doses if the person's respiratory rate and/or the person's activity state continue have not improved after the first dose. The device can include a wireless communication device to contact a third party after one or more doses have been administered.Type: ApplicationFiled: February 13, 2017Publication date: August 16, 2018Inventor: Ross MacDonald
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Publication number: 20180162942Abstract: This disclosure provides methods for treating a subject afflicted with a tumor derived from a renal cell carcinoma. The methods comprise administering a first dose to a subject of an anti-PD-1 antibody or antigen-binding portion thereof and/or an anti-PD-L1 antibody or antigen-binding portion thereof, and administering a second dose to the subject, wherein the subject exhibited differential expression in one or more biomarker genes, e.g., CTLA-4, TIGIT, and/or PD-L2, following administration of the first dose.Type: ApplicationFiled: May 27, 2016Publication date: June 14, 2018Applicant: Bristol-Myers Squibb CompanyInventors: Jason Samuel SIMON, Petra B. ROSS-MACDONALD
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Patent number: 9802077Abstract: There is accordingly provided an exercise apparatus including an inner housing upon which a user may stand. The apparatus includes an outer housing rotatably coupled to the inner housing. The apparatus includes a handlebar coupled to and extending upwards from the outer housing. The apparatus includes a mount for retaining one or more weights thereon. The mount operatively connects to the outer housing and is enclosed within one of the housings.Type: GrantFiled: July 10, 2015Date of Patent: October 31, 2017Assignee: My Turn Health and Fitness LimitedInventor: Ross MacDonald
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Publication number: 20160074702Abstract: There is accordingly provided an exercise apparatus including an inner housing upon which a user may stand. The apparatus includes an outer housing rotatably coupled to the inner housing. The apparatus includes a handlebar coupled to and extending upwards from the outer housing. The apparatus includes a mount for retaining one or more weights thereon. The mount operatively connects to the outer housing and is enclosed within one of the housings.Type: ApplicationFiled: July 10, 2015Publication date: March 17, 2016Inventor: Ross MacDonald
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Patent number: 8576074Abstract: A capacitor warning circuit, and method of providing a warning are provided, the circuit comprising a capacitor capable of being charged to a charged state and a warning circuit coupled to the capacitor and adapted to provide an indication that the capacitor is in the charged state, wherein the warning circuit is powered by energy accumulated in the capacitor when the capacitor is in the charged state.Type: GrantFiled: June 22, 2010Date of Patent: November 5, 2013Assignee: General AtomicsInventors: Frederick W. MacDougall, Mark Allen Schneider, Ross MacDonald
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Publication number: 20110012740Abstract: A capacitor warning circuit, and method of providing a warning are provided, the circuit comprising a capacitor capable of being charged to a charged state and a warning circuit coupled to the capacitor and adapted to provide an indication that the capacitor is in the charged state, wherein the warning circuit is powered by energy accumulated in the capacitor when the capacitor is in the charged state.Type: ApplicationFiled: June 22, 2010Publication date: January 20, 2011Applicant: GENERAL ATOMICSInventors: Frederick W. MACDOUGALL, Mark Allen SCHNEIDER, Ross MACDONALD
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Publication number: 20040142888Abstract: The present invention provides methods for inducing apoptosis in a cell, the methods generally involving contacting the cell with an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for treating a disorder related to unwanted cell proliferation in an individual, the methods generally involving administering to the individual an agent that reduces the level and/or activity of RabGGT. The present invention further provides methods for reducing apoptosis in a cell, the methods generally involving increasing the level and/or activity of RabGGT in the cell. The present invention further provides methods for treating disorders associated with excessive apoptosis. The present invention further provides methods for identifying a cell that is amenable to treatment with the methods of the present invention. The present invention further provides methods for modulating a binding event between RabGGT and a RabGGT interacting protein.Type: ApplicationFiled: August 7, 2003Publication date: July 22, 2004Inventors: Veeraswamy Manne, Mark Lynch, Petra B. Ross-MacDonald, Terry Stouch, Naomi Laing, Pamela Carroll, Kevin Fitzgerald, Louis J. Lombardo, Michael R. Costa, Mark E. Maxwell, Rachel M. Kindt, Mark R. Lackner, Tak Hung, Carol L. O'Brian, Hai Guang Zhang, Katherine S. Brown, Jae Moon Lee