Abstract: Systems and methods for analog to digital conversion that may be implemented using a digital to analog converter (DAC) to provide negative feedback to at least Partially cancel one or more signals (e.g., one or more interfering signals present with one or more desired signals, one or more strong desired signals etc.) at the analog input of an analog to digital converter (ADC), and that may be used to extend the effective dynamic range of an ADC. The effective dynamic range of an ADC may be extended by detecting and isolating signals and using digital adaptive digital filtering along with a digital to analog converter (DAC) to provide negative feedback to cancel the signal/s at the input of the ADC.