Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to crystalline polymorph forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one.

Abstract: The present disclosure relates to crystalline polymorph forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazol[1,5-a]pyrazin-8-one.

Abstract: Systems of weldable wires, powder, and materials comprising an aluminum-magnesium-scandium alloy, and methods for additive manufacturing the alloy are described. The alloy can be utilized in additive manufacturing to additively manufacture at industrial scales. With post treatment, the additive manufactured alloys can have advantageous properties for aerospace applications.

Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)b enzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.

Abstract: A sealing device generally includes a rotatable support cylinder having an outer, circumferential surface and a heating element disposed about such surface and secured thereto such that the heating element rotates therewith. The heating element is coiled about the outer surface of the cylinder in the form of an overlapping helical pattern. Juxtaposed film plies may be sealed together by bringing the sealing device into rotational contact with the juxtaposed film plies and heating the heating element to a temperature sufficient to cause the film plies to seal together.

Abstract: The present invention is directed to processes for making various polymorphs of tucatinib, designated herein as Form I, Form II, and Form III of tucatinib. These forms can then be used to prepare pharmaceutical formations containing tucatinib. Tucatinib is a tyrosine kinase inhibitor that is indicated for the treatment of breast cancer.

Abstract: A sealing device generally includes a rotatable support cylinder having an outer, circumferential surface and a heating element disposed about such surface and secured thereto such that the heating element rotates therewith. The heating element is coiled about the outer surface of the cylinder in the form of an overlapping helical pattern. Juxtaposed film plies may be sealed together by bringing the sealing device into rotational contact with the juxtaposed film plies and heating the heating element to a temperature sufficient to cause the film plies to seal together.

Abstract: The present disclosure relates to crystalline polymorph forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazol[1,5-a]pyrazin-8-one.

Abstract: A sealing device generally includes a rotatable support cylinder having an outer, circumferential surface and a heating element disposed about such surface and secured thereto such that the heating element rotates therewith. The heating element is coiled about the outer surface of the cylinder in the form of an overlapping helical pattern. Juxtaposed film plies may be sealed together by bringing the sealing device into rotational contact with the juxtaposed film plies and heating the heating element to a temperature sufficient to cause the film plies to seal together.

Abstract: A sealing device generally includes a rotatable support cylinder having an outer, circumferential surface and a heating element disposed about such surface and secured thereto such that the heating element rotates therewith. The heating element is coiled about the outer surface of the cylinder in the form of an overlapping helical pattern. Juxtaposed film plies may be sealed together by bringing the sealing device into rotational contact with the juxtaposed film plies and heating the heating element to a temperature sufficient to cause the film plies to seal together.

Abstract: A sealing device generally includes a rotatable support cylinder having an outer, circumferential surface and a heating element disposed about such surface and secured thereto such that the heating element rotates therewith. The heating element is coiled about the outer surface of the cylinder in the form of an overlapping helical pattern. Juxtaposed film plies may be sealed together by bringing the sealing device into rotational contact with the juxtaposed film plies and heating the heating element to a temperature sufficient to cause the film plies to seal together.

Abstract: A sealing device generally includes a rotatable support cylinder having an outer, circumferential surface and a heating element disposed about such surface and secured thereto such that the heating element rotates therewith. The heating element is coiled about the outer surface of the cylinder in the form of an overlapping helical pattern. Juxtaposed film plies may be sealed together by bringing the sealing device into rotational contact with the juxtaposed film plies and heating the heating element to a temperature sufficient to cause the film plies to seal together.

Abstract: An apparatus for making inflated containers from a film web having two juxtaposed film plies generally includes (a) a first sealing device for producing a series of transverse seals that bond the film plies together, (b) an inflation assembly for directing gas between the film plies, (c) a second sealing device for producing one or more longitudinal seals that bond the film plies together, the transverse seals and the longitudinal seals intersecting to enclose the gas between the film plies to thereby form one or more inflated containers, and (d) at least one intermediate sealing element for producing one or more intermediate seals within each inflated container, the intermediate seals partitioning the containers into two or more compartments and providing at least one flow passageway between the compartments to allow the compartments to fluidly communicate with one another.

Abstract: A packaging apparatus wherein each product is packaged by enveloping the product in flexible packaging material. A programmed microprocessor calculates the length of flexible packaging material needed to package the product based on the physical dimensions of the product, calculates the weight of the flexible packaging material needed, and calculates a total package weight as the sum of the weight of the product and the calculated weight of the flexible packaging material. A printer prints information specific to the product that is being packaged onto a label that is then affixed to the flexible packaging material prior to the product being packaged. The information can be a function of the package weight, and the calculated total package weight can be communicated from the microprocessor to the printer. Finally, the product is packaged in the flexible packaging material having the label already affixed thereto.

Abstract: A packaging apparatus wherein each product is packaged by enveloping the product in flexible packaging material. A programmed microprocessor calculates the length of flexible packaging material needed to package the product based on the physical dimensions of the product, calculates the weight of the flexible packaging material needed, and calculates a total package weight as the sum of the weight of the product and the calculated weight of the flexible packaging material. A printer prints information specific to the product that is being packaged onto a label that is then affixed to the flexible packaging material prior to the product being packaged. The information can be a function of the package weight, and the calculated total package weight can be communicated from the microprocessor to the printer. Finally, the product is packaged in the flexible packaging material having the label already affixed thereto.

Abstract: A packaging method and apparatus wherein each product is packaged by enveloping the product in flexible packaging material. A programmed microprocessor calculates the length of flexible packaging material needed to package the product based on the physical dimensions of the product, calculates the weight of the flexible packaging material needed, and calculates a total package weight as the sum of the weight of the product and the calculated weight of the flexible packaging material. A printer prints information specific to the product that is being packaged onto a label that is then affixed to the flexible packaging material prior to the product being packaged. The information can be a function of the package weight, and the calculated total package weight can be communicated from the microprocessor to the printer. Finally, the product is packaged in the flexible packaging material having the label already affixed thereto.

Abstract: A packaging method and apparatus wherein each product is packaged by capturing the product in flexible packaging material. The packing apparatus includes a product detector for detecting the presence or absence of a product to be packaged. The detection of the product may cause the advancement of packaging material and the product through a nipping station to form a package. The failure to detect a product may cause the advancement of the packaging material to stop and conserve packaging material until a product is detected. The product detector may be a color sensor trained to detect a color of the first web, a luminescence sensor trained to detect a luminance of the first web, or a light-sensitive sensor trained to detect a difference in light passing through the first web. Also, a luminescence additive may be joined with the lower web to provide a distinct luminance.

Abstract: A packaging method and apparatus wherein each product is packaged by enveloping the product in flexible packaging material. A programmed microprocessor calculates the length of flexible packaging material needed to package the product based on the physical dimensions of the product, calculates the weight of the flexible packaging material needed, and calculates a total package weight as the sum of the weight of the product and the calculated weight of the flexible packaging material. A printer prints information specific to the product that is being packaged onto a label that is then affixed to the flexible packaging material prior to the product being packaged. The information can be a function of the package weight, and the calculated total package weight can be communicated from the microprocessor to the printer. Finally, the product is packaged in the flexible packaging material having the label already affixed thereto.