Abstract: Embodiments of syringes and components thereof described herein provide reduced compliance from flexing or deformation, of not only the syringe barrel but also of the syringe plunger rod and plunger seal. Embodiments of syringes and components thereof described herein also provide improved sealing between the barrel and the syringe plunger rod, and improved resistance to pressure. Embodiments of syringes and components thereof described herein are advantageously suited for use with an infusion pump which may subject syringes to many start/stop operations over a period of hours, sometimes at very low flow rates.