Abstract: Provided is a sevoflurane anesthetic product which can remain substantially undegraded after long periods of storage, as well as a method for preparing the product. The product comprises sevoflurane in a glass container having a water content of less than 130 ppm. The method comprises drying sevoflurane having a water content of greater than 130 ppm to a water content les than 130 ppm. A preferred method of drying comprises contacting a sevoflurane composition having a water content of greater than 130 ppm with alumina-containing molecular sieves such that the water content is reduced to less than 130 ppm.

Abstract: A method for the preparation of (CF3)2CHOCH2F (Sevoflurane) is presented, which comprises providing a mixture of (CF3)2CHOCH2Cl, potassium fluoride, water, and a phase transfer catalyst and reacting the mixture to form (CF3)2CHOCH2F.

Abstract: A method for the preparation of 1,2,2,2-tetrafluoroethyl difluoromethyl ether (CF3CHFOCHF2, Desflurane) is provided, which comprises reacting CF3CHClOCHF2 (isoflurane) and hydrogen fluoride in the presence of antimony pentafluoride such that desflurane is formed.