Patents by Inventor Ross Wadsworth

Ross Wadsworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reverse transcriptase variants
    Patent number: 11639499
    Abstract: The present invention provides MMLV reverse transcriptase enzymes with increased thermal stability as compared with wild type MMLV and AMV reverse transcriptases. The improved thermal stability allows for reverse transcription of RNA to cDNA at temperatures above 37° C., thereby reducing error rates introduced during cDNA synthesis. As a result, the reverse transcriptases of the invention allow for increased accuracy in the determination of transcriptomes of living organisms.
    Type: Grant
    Filed: September 8, 2022
    Date of Patent: May 2, 2023
    Assignee: Watchmaker Genomics, Inc.
    Inventors: Julie Walker, Bjarne Faurholm, Ross Wadsworth, Brian A. Kudlow
  • SYSTEM AND METHOD FOR NUCLEIC ACID LIBRARY PREPARATION VIA TEMPLATE SWITCHING MECHANISM
    Publication number: 20220380823
    Abstract: The disclosure provides a composition comprising a double-stranded deoxyribonucleic acid (dsDNA) sequence comprising from 5? to 3?, a sequence comprising a first adaptor sequence, a template sequence, and a second adaptor sequence, wherein the second adaptor sequence comprises a hybridization site for a template switching oligonucleotide (TSO). The disclosure provides methods for making the compositions of the disclosure using a template switching mechanism to add non-templated basepairs to the ends of a DNA molecule, hybridize a TSO to the non-templated basepairs, and then extend the sequence complementary to the TSO to add an adaptor.
    Type: Application
    Filed: July 19, 2022
    Publication date: December 1, 2022
    Inventors: Jennifer Hsieh, Paul McEwan, Martin Ranik, Marliz Iain McAllister Strydom, Eric van der Walt, Ross Wadsworth
  • System and method for nucleic acid library preparation via template switching mechanism
    Patent number: 11427846
    Abstract: The disclosure provides a composition comprising a double-stranded deoxyribonucleic acid (dsDNA) sequence comprising from 5? to 3?, a sequence comprising a first adaptor sequence, a template sequence, and a second adaptor sequence, wherein the second adaptor sequence comprises a hybridization site for a template switching oligonucleotide (TSO). The disclosure provides methods for making the compositions of the disclosure using a template switching mechanism to add non-templated basepairs to the ends of a DNA molecule, hybridize a TSO to the non-templated basepairs, and then extend the sequence complementary to the TSO to add an adaptor.
    Type: Grant
    Filed: June 4, 2020
    Date of Patent: August 30, 2022
    Assignee: Kapa Biosystems, Inc.
    Inventors: Jennifer Hsieh, Paul McEwan, Martin Ranik, Marliz Strydom, Eric van der Walt, Ross Wadsworth
  • SYSTEM AND METHOD FOR NUCLEIC ACID LIBRARY PREPARATION VIA TEMPLATE SWITCHING MECHANISM
    Publication number: 20200291440
    Abstract: The disclosure provides a composition comprising a double-stranded deoxyribonucleic acid (dsDNA) sequence comprising from 5? to 3?, a sequence comprising a first adaptor sequence, a template sequence, and a second adaptor sequence, wherein the second adaptor sequence comprises a hybridization site for a template switching oligonucleotide (TSO). The disclosure provides methods for making the compositions of the disclosure using a template switching mechanism to add non-templated basepairs to the ends of a DNA molecule, hybridize a TSO to the non-templated basepairs, and then extend the sequence complementary to the TSO to add an adaptor.
    Type: Application
    Filed: June 4, 2020
    Publication date: September 17, 2020
    Inventors: Jennifer Hsieh, Paul McEwan, Martin Ranik, Marliz Strydom, Eric van der Walt, Ross Wadsworth