Patents by Inventor Ross Wentworth Stephens
Ross Wentworth Stephens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11896683Abstract: The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising a polycation with multiple pendant metal-chelating side-chains. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.Type: GrantFiled: December 15, 2017Date of Patent: February 13, 2024Assignee: THE AUSTRALIAN NATIONAL UNIVERSITYInventors: Ross Wentworth Stephens, Gregory David Tredwell, Karen Joanne Knox, Lee Andrew Philip, Rebecca Greenlees, Keira Beattie
-
Publication number: 20200038528Abstract: The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising a polycation with multiple pendant metal-chelating side-chains. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.Type: ApplicationFiled: December 15, 2017Publication date: February 6, 2020Inventors: Ross Wentworth Stephens, Gregory David Tredwell, Karen Joanne Knox, Lee Andrew Philip, Rebecca Greenlees, Keira Beattie
-
Patent number: 10232062Abstract: The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising electron donating groups. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging, and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.Type: GrantFiled: December 20, 2013Date of Patent: March 19, 2019Assignee: The Australian National UniversityInventors: Ross Wentworth Stephens, Jessica Louise Bell
-
Patent number: 9381262Abstract: The present invention relates to a method for preparing a radiolabeled synthetic polymer, the method comprising contacting a synthetic polymer with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising an electrolyte concentration or pH selected to promote short-range attractive forces between the nanoparticles and the synthetic polymer by attenuating long-range electrostatic repulsive forces.Type: GrantFiled: April 23, 2009Date of Patent: July 5, 2016Assignee: The Australian National UniversityInventors: Ross Wentworth Stephens, Timothy John Senden, David Wallace King
-
Patent number: 9283291Abstract: The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.Type: GrantFiled: April 23, 2009Date of Patent: March 15, 2016Assignee: The Australian National UniversityInventors: Ross Wentworth Stephens, Timothy John Senden, David Wallace King
-
Patent number: 9226939Abstract: The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.Type: GrantFiled: November 29, 2011Date of Patent: January 5, 2016Assignee: THE AUSTRALIAN NATIONAL UNIVERSITYInventors: Ross Wentworth Stephens, Christopher Richard Parish, Craig Geoffrey Freeman, Timothy John Senden
-
Patent number: 8778300Abstract: A method of forming an injectable radioactive composition, the method comprising the steps of: (a) depositing a solid form of technetium onto a carbon crucible; (b) preheating the solid form of technetium to remove any carrier; (c) plasma ablating the technetium and portions of the carbon crucible; (d) allowing the carbon and technetium metal to co-condense from the gas phase to produce a nanoparticle composite aerosol in an inert gas; (e) dispersing the nanoparticle composite in water containing a low concentration of surfactant using an electrostatic precipitator; (f) size fractionating the nanoparticle dispersion by filtration with hydrophilic membranes of known pore size.Type: GrantFiled: April 28, 2006Date of Patent: July 15, 2014Assignee: The Australian National UniversityInventors: William Martin Burch, Timothy John Senden, Ross Wentworth Stephens, Beverley Ann Browitt
-
Publication number: 20130338097Abstract: The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.Type: ApplicationFiled: November 29, 2011Publication date: December 19, 2013Applicant: THE AUSTRALIAN NATIONAL UNIVERSITYInventors: Ross Wentworth Stephens, Christopher Richard Parish, Craig Geoffrey Freeman, Timothy John Senden
-
Publication number: 20110165070Abstract: The present invention relates to a method for preparing a radiolabeled synthetic polymer, the method comprising contacting a synthetic polymer with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising an electrolyte concentration or pH selected to promote short-range attractive forces between the nanoparticles and the synthetic polymer by attenuating long-range electrostatic repulsive forces.Type: ApplicationFiled: April 23, 2009Publication date: July 7, 2011Applicant: The Australian National UniversityInventors: Ross Wentworth Stephens, Timothy John Senden, David Wallace King
-
Publication number: 20110165069Abstract: The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous medium comprising a pH selected to promote short-range attractive forces between the nanoparticles and the macromolecule by attenuating repulsive electrostatic forces.Type: ApplicationFiled: April 23, 2009Publication date: July 7, 2011Applicant: The Australian National UniversityInventors: Ross Wentworth Stephens, Timothy John Senden, David Wallace King
-
Publication number: 20110002847Abstract: A method of forming an injectable radioactive composition, the method comprising the steps of: (a) depositing a solid form of technetium onto a carbon crucible; (b) preheating the solid form of technetium to remove any carrier; (c) plasma ablating the technetium and portions of the carbon crucible; (d) allowing the carbon and technetium metal to co-condense from the gas phase to produce a nanoparticle composite aerosol in an inert gas; (e) dispersing the nanoparticle composite in water containing a low concentration of surfactant using an electrostatic precipitator; (f) size fractionating the nanoparticle dispersion by filtration with hydrophilic membranes of known pore size.Type: ApplicationFiled: April 28, 2006Publication date: January 6, 2011Applicant: The Australian National UniversityInventors: Rodney James Browitt, Beverley Ann Browitt, William Martin Burch, Timothy John Senden, Ross Wentworth Stephens
-
Patent number: 7722856Abstract: A method for forming an inhalable isotope compound suitable for use in patient medical diagnosis, the method comprising the steps of: (a) electrolytic loading of a carbon crucible with the isotope; (b) sublimating any isotope carrier in the crucible; (c) ablating the isotope in a carbon crucible, forming an ablation aerosol; (d) directly delivering the aerosol for immediate use by a patient. The isotope can comprise technetium.Type: GrantFiled: February 24, 2006Date of Patent: May 25, 2010Assignee: Cyclomedica Australia Pty LimitedInventors: Rodney James Browitt, William Martin Burch, Timothy John Senden, Ross Wentworth Stephens, David DeForest Shaw
-
Patent number: 5962418Abstract: The present invention relates to compounds comprising the amino acid sequences of the formulae (IA): -CVNENGGCEQYCSD-, (IB): -FCLPAFEGRNCE- and/or (IC): -RCHEGYSLLADGVSCT- as well as peptide fragments thereof, esters, amides, salts and cyclic derivatives thereof, functional analogues thereof and extended peptide chains carrying amino acids or peptides at the termini of the above sequences or fragments, for use in the prevention or inhibition of binding of tissue factor to FVII.Type: GrantFiled: May 28, 1996Date of Patent: October 5, 1999Assignee: Nycomed Imaging A/SInventors: Kjell Steinar Sakariassen, Ross Wentworth Stephens, Lars Orning