Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Systems, methods, and computer-readable media for providing low-latency markets for wagering on sporting events are disclosed. In some embodiments, an outcome matrix may be generated by a plurality of contest simulations utilizing statistical data of a history of sporting events. Outcome data of the outcome matrix may be indicative of probabilities of events occurring during an upcoming contest. The probabilities may be calculated, and markets may be priced based on the calculated probabilities. The priced markets may be provided to users by a graphical user interface by user computing device. Furthermore, users may request user-requested markets by inputting different markets into the GUI. The user-requested markets may then be priced using the outcome data of the outcome matrix and stored calculations thus, providing new markets based on the user-requested markets from the outcome matrix without generating new simulations.

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

Abstract: Example implementations include a method, apparatus and computer-readable medium for attested verification of personal data, comprising transmitting an access request to a verifying entity, wherein the access request is for a service, product, or information accessible solely to an authorized user. The implementations include receiving, from the verifying entity, a verification request that indicates at least one attribute of personal data that classifies a user as the authorized user. The implementations include generating a verification response indicating possession of the at least one attribute. The implementations include identifying, in a digital wallet, attested data issued by a trusted entity that confirms possession of the at least one attribute of the personal data. The implementations include transmitting, to the verifying entity, the verification response and the attested data without including the personal data.

Abstract: The disclosure relates to gene repressor systems comprising catalytically-dead Class 2 CRISPR proteins and one or more transcription repressor domains linked to the catalytically-dead Class 2 CRISPR protein as a fusion protein, as well as a guide ribonucleic acid (gRNA); and methods of making and using same.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: A system of identifying and tracking occupants of a building is provided. The system includes multiple detector devices that each receive an identification signal from an identification device and multiple image capture devices that each output an image signal depicting a respective monitored location of the building. The system further includes a processing circuit that receives the identification signal from one of the detector devices, associates the detector device with a detector location, retrieves a user attribute, and receives the image signal from one of the image capture devices depicting a monitored location corresponding to the detector location. The processing circuit further generates an annotated video signal including the user attribute overlaid on the video signal, and displays the annotated video signal on a display device.

Abstract: A system of identifying and tracking occupants of a building is provided. The system includes multiple detector devices that each receive an identification signal from an identification device and multiple image capture devices that each output an image signal depicting a respective monitored location of the building. The system further includes a processing circuit that receives the identification signal from one of the detector devices, associates the detector device with a detector location, retrieves a user attribute, and receives the image signal from one of the image capture devices depicting a monitored location corresponding to the detector location. The processing circuit further generates an annotated video signal including the user attribute overlaid on the video signal, and displays the annotated video signal on a display device.