Patents by Inventor Rotem Edgar

Rotem Edgar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KLEBSIELLA BACTERIOPHAGE AND USES THEREOF
    Publication number: 20240075084
    Abstract: A composition comprising at least two different strains of isolated bacteriophages, each capable of infecting a bacteria of the species Klebsiella pneumoniae, wherein at least one of said at least two different strains of isolated bacteriophages has a genomic nucleic acid sequence at least 90% identical to one of the nucleic acid sequence as set forth in SEQ ID NOs: 1-30. Uses thereof are also disclosed.
    Type: Application
    Filed: January 20, 2022
    Publication date: March 7, 2024
    Applicant: Biomx Ltd.
    Inventors: Eyal WEINSTOCK, Iddo Nadav WEINER, Maya KAHAN-HANUM, Efrat KHABRA, Noa BEN-YISHAI, Dana INBAR, Rotem EDGAR
  • Bacteriophages for reducing toxicity of bacteria
    Patent number: 8865158
    Abstract: A genetically modified bacteriophage is disclosed which comprises: (i) an exogenous polynucleotide which encodes an agent which reduces the toxicity of a bacterium; and (ii) an exogenous polynucleotide which encodes a selectable marker. Uses thereof and kits comprising same are also disclosed.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: October 21, 2014
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Qimron, Rotem Edgar, Nir Friedman
  • BACTERIOPHAGES FOR REDUCING TOXICITY OF BACTERIA
    Publication number: 20130315869
    Abstract: A genetically modified bacteriophage is disclosed which comprises: (i) an exogenous polynucleotide which encodes an agent which reduces the toxicity of a bacterium; and (ii) an exogenous polynucleotide which encodes a selectable marker. Uses thereof and kits comprising same are also disclosed.
    Type: Application
    Filed: May 22, 2012
    Publication date: November 28, 2013
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud QIMRON, Rotem Edgar, Nir Friedman
  • Bacteriophage/Quantum-Dot (Phage-QD) Nanocomplex to Detect Biological Targets in Clinical and Environmental Isolates
    Publication number: 20110086338
    Abstract: The invention is related to a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, a complex that comprises a biotinylated bacteriophage and a biotin-specific ligand conjugated bioconjugate, and a method of detecting a bacterial cell in a sample comprising contacting the sample with a non-biotinylated bacteriophage that comprises a nucleic acid sequence encoding a biotinylation domain, wherein the bacteriophage is specific to the bacterial cell.
    Type: Application
    Filed: February 16, 2006
    Publication date: April 14, 2011
    Inventors: Jeeseong Hwang, Rotem Edgar, Michael Mckinstry, Gary Giulian, Carl Merril, Sankar Adhya
  • Reporter plasmid phage packaging system for detection of bacteria
    Publication number: 20090155768
    Abstract: The invention is related to a transducing particle that comprises a bacteriophage coat and a DNA core that comprises plasmid DNA comprising: a) a host-specific bacteriophage packaging site wherein the packaging site is substantially in isolation from sequences naturally occurring adjacent thereto in the bacteriophage genome, b) a reporter gene, c) a bacteria-specific promoter operably linked to said reporter gene, d) a bacteria-specific origin of replication, and optionally e) an antibiotic resistance gene. The invention includes phage transducing particles, methods of making transducing particles, and methods of using the transducing particles in bacterial detection.
    Type: Application
    Filed: April 7, 2005
    Publication date: June 18, 2009
    Inventors: Dean Scholl, Carl R. Merril, Sankar Adhya, Michael McKinstry, Rotem Edgar