Patents by Inventor Rotem Karni

Rotem Karni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF GENETIC DISEASES CHARACTERIZED BY UNSTABLE mRNAs
    Publication number: 20220339236
    Abstract: Methods of treating a disease characterized by mRNA instability or nonsense-mediated decay of an mRNA of a disease-associated gene in a subject by administering a pharmaceutical composition comprising at least one agent that decreases FTO expression, function or both are provided. Kits and pharmaceutical compositions comprising an agent that decreases FTO expression, function or both and a read-through promoting agent are also provided, as are methods of determining suitability of a subject to be treated with an agent that decreases FTO expression, function or both.
    Type: Application
    Filed: September 23, 2020
    Publication date: October 27, 2022
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Rotem KARNI, Adi AMAR-SCHWARTZ
  • NEOANTIGENS CREATED BY ABERRANT-INDUCED SPLICING AND USES THEREOF IN ENHANCING IMMUNOTHERAPY
    Publication number: 20220098578
    Abstract: The invention relates to methods, compositions, and splicing modulating agents comprising nucleic acid sequences, specifically, antisense oligonucleotides and gene editing compounds. The splicing modulating agents of the invention are used in methods for producing neoantigens in subjects suffering from neoplastic disorders, by the induction of aberrant splicing events. The modulators of the invention are further used by the invention in enhancing immunotherapy.
    Type: Application
    Filed: January 30, 2020
    Publication date: March 31, 2022
    Inventors: Erez LEVANON, Rotem KARNI, Ariel FEIGLIN, Adi MOGILEVSKY, Eli KOPEL, Michal BARAK
  • Decoy oligonucleotides for the treatment of diseases
    Patent number: 10781445
    Abstract: An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a splicing-factor binding site. The oligonucleotide is no more than 150 bases and may be devoid of a sequence that allows hybridization thereof to cellular RNA under physiological conditions. The oligonucleotide inhibits overall cellular splicing activity of a specific splicing factor. Pharmaceutical compositions comprising the oligonucleotide and uses thereof are further disclosed.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: September 22, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventor: Rotem Karni
  • DECOY OLIGONUCLEOTIDES FOR THE TREATMENT OF DISEASES
    Publication number: 20170327825
    Abstract: An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a splicing-factor binding site. The oligonucleotide is no more than 150 bases and may be devoid of a sequence that allows hybridization thereof to cellular RNA under physiological conditions. The oligonucleotide inhibits overall cellular splicing activity of a specific splicing factor. Pharmaceutical compositions comprising the oligonucleotide and uses thereof are further disclosed.
    Type: Application
    Filed: March 10, 2016
    Publication date: November 16, 2017
    Inventor: Rotem KARNI
  • Methods of treating and diagnosing diseases using agents that regulate the alternative splicing pathway
    Patent number: 9745581
    Abstract: A method of determining a treatment for an inflammatory disorder in a subject, is disclosed. The method comprises determining an amount of SRSF6 in a sample from the subject, wherein an amount of the SRSF6 is indicative of the treatment. Methods of diagnosing inflammatory disorders and treating same are also disclosed.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: August 29, 2017
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Rotem Karni, Vered Ben Hur, Avraham Maimon
  • METHODS OF TREATING AND DIAGNOSING DISEASES USING AGENTS THAT REGULATE THE ALTERNATIVE SPLICING PATHWAY
    Publication number: 20150141489
    Abstract: A method of determining a treatment for an inflammatory disorder in a subject, is disclosed. The method comprises determining an amount of SRSF6 in a sample from the subject, wherein an amount of the SRSF6 is indicative of the treatment. Methods of diagnosing inflammatory disorders and treating same are also disclosed.
    Type: Application
    Filed: May 16, 2013
    Publication date: May 21, 2015
    Inventors: Rotem Karni, Vered Ben Hur, Avraham Maimon