Patents by Inventor Roujian Zhang

Roujian Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Measurement of protein using inclusion body dry weight
    Patent number: 8492113
    Abstract: The present invention is directed to improved methods for efficiently producing recombinant proteins. More specifically, the invention relates to a process for calculating the protein in inclusion bodies before the refolding step in large scale recombinant protein production, thereby improving the efficiency of the refolding step and overall yield and quality of the sample protein.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: July 23, 2013
    Assignee: Amgen Inc.
    Inventor: Roujian Zhang
  • Materials and methods for controlling isotope effects during fractionation of analytes
    Patent number: 7901943
    Abstract: Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy isotopes other than deuterium. The invention facilitates intelligent data acquisition. After sample fractionation, isotope abundance ratios are calculated using mass spectrometry, and analytes of interest are identified in real time.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: March 8, 2011
    Assignee: Purdue Research Foundation
    Inventors: Fred E. Regnier, Roujian Zhang
  • MEASUREMENT OF PROTEIN USING INCLUSION BODY DRY WEIGHT
    Publication number: 20110045527
    Abstract: The present invention is directed to improved methods for efficiently producing recombinant proteins. More specifically, the invention relates to a process for calculating the protein in inclusion bodies before the refolding step in large scale recombinant protein production, thereby improving the efficiency of the refolding step and overall yield and quality of the sample protein.
    Type: Application
    Filed: July 9, 2008
    Publication date: February 24, 2011
    Applicant: AMGEN INC.
    Inventor: Roujian Zhang
  • Materials and methods for controlling isotope effects during fractionation of analytes
    Publication number: 20090148952
    Abstract: Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy isotopes other than deuterium. The invention facilitates intelligent data acquisition. After sample fractionation, isotope abundance ratios are calculated using mass spectrometry, and analytes of interest are identified in real time.
    Type: Application
    Filed: November 3, 2008
    Publication date: June 11, 2009
    Applicant: Purdue Research Foundation
    Inventors: Fred E. Regnier, Roujian Zhang
  • Materials and methods for controlling isotope effects during fractionation of analytes
    Patent number: 7449170
    Abstract: Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy isotopes other than deuterium. The invention facilitates intelligent data acquisiton. After sample fractionation, isotope abundance ratios are calculated using mass spectrometry, and analytes of interest are identified in real time.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: November 11, 2008
    Assignee: Purdue Research Foundation
    Inventors: Fred E. Regnier, Roujian Zhang
  • Materials and methods for controlling isotope effects during fractionation of analytes
    Publication number: 20030186326
    Abstract: Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy isotopes other than deuterium. The invention facilitates intelligent data acquisiton. After sample fractionation, isotope abundance ratios are calculated using mass spectrometry, and analytes of interest are identified in real time.
    Type: Application
    Filed: September 27, 2002
    Publication date: October 2, 2003
    Applicant: Purdue Research Foundation
    Inventors: Fred E. Regnier, Roujian Zhang