Patents by Inventor Roxane SIMEONE

Roxane SIMEONE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant BCG expressing antigens of the ESX-1 secretion system
    Patent number: 10010597
    Abstract: Recombinant strains of Mycobacterium bovis bacille Calmette-Guerin (M. bovis BCG) comprising a heterologous nucleic acid sequence of Mycobacterium marinum (M. marinum) are provided. In some embodiments the heterologous nucleic acid sequence of M. marinum comprises a plurality of open reading frames, wherein the plurality of open reading frames comprise open reading frames that encode proteins each at least 95% homologous to the Mycobacterium marinum (M. marinum) proteins MMAR5445, MMAR5446, MMAR5447, MMAR5448, MMAR5449, MMAR5450, MMAR5451, MMAR5452, MMAR5453, and MMAR5455. In some embodiments the plurality of open reading frames further comprise an open reading frame that encodes a protein at least 95% homologous to the M. marinum proteins MMAR5443, MMAR5444, and MMAR5457. In some embodiments the plurality of open reading frames further comprise open reading frames that encode proteins at least 95% homologous to the M.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: July 3, 2018
    Assignee: INSTITUT PASTEUR
    Inventors: Roland Brosch, Laleh Majlessi, Nadine Honore, Matthias Groschel, Fadel Sayes, Roxane Simeone
  • RECOMBINANT MYCOBACTERIUM BOVIS BCG EXPRESSING ANTIGENS OF THE MYCOBACTERIUM MARINUM ESX-1 SECRETION SYSTEM
    Publication number: 20170106073
    Abstract: Recombinant strains of Mycobacterium bovis bacille Calmette-Guerin (M. bovis BCG) comprising a heterologous nucleic acid sequence of Mycobacterium marinum (M. marinum) are provided. In some embodiments the heterologous nucleic acid sequence of M. marinum comprises a plurality of open reading frames, wherein the plurality of open reading frames comprise open reading frames that encode proteins each at least 95% homologous to the Mycobacterium marinum (M. marinum) proteins MMAR5445, MMAR5446, MMAR5447, MMAR5448, MMAR5449, MMAR5450, MMAR5451, MMAR5452, MMAR5453, and MMAR5455. In some embodiments the plurality of open reading frames further comprise an open reading frame that encodes a protein at least 95% homologous to the M. marinum proteins MMAR5443, MMAR5444, and MMAR5457. In some embodiments the plurality of open reading frames further comprise open reading frames that encode proteins at least 95% homologous to the M.
    Type: Application
    Filed: June 3, 2015
    Publication date: April 20, 2017
    Inventors: Roland BROSCH, Laleh MAJLESSI, Nadine HONORE, Matthias GROSCHEL, Fadel SAYES, Roxane SIMEONE