Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: A folding knife includes a blade having a tang. The tang has a cylindrical wall defining a pivot hole. A bearing counter bore pocket is disposed in at least one side of the tang. At least one bearing is disposed in the bearing counter bore pocket. An axis lock pin is slidingly mounted within slots in either side of a handle. At least one axis lock spring applies a spring bias between the handle and the axis lock pin, pressing the axis lock pin against an outside edge of the tang to transmit a force of the spring bias to the bearing perpendicular to a blade pivot axis to set a manual blade opening force.

Abstract: A multiple purpose pocket tool having an elongated housing defining an open cavity, a plurality of elongated ancillary tools pivotally attached to one end of the housing at their proximal ends, and an elongated cover plate pivotally attached to the opposite end of the housing. Each of the ancillary tools includes a slot formed transversely across the top and bottom edges thereof, adjacent their proximal ends. The cover plate includes a downwardly extending flange which engages one of the slots formed in each of the tools when positioned in its terminal closed position, thereby locking the tools in place. The cover plate further includes a protrusion formed on the inwardly facing surface of one of its sidewalls which engages an aperture formed through the corresponding sidewall of the housing when in either its terminal open or closed position, thereby locking the cover plate in such position.

Abstract: A trap for insects such as ants is described which fits over the insect hill or mound and traps both emerging and returning members of the insect community. The trap is provided with a unique cover which prevents winged members of the community from flying out of the trap to establish nests and reproduce elsewhere. Provision is also made in the trap for drainage so that water does not accumulate and destroy the effectiveness of the trap.

Abstract: A retractable goal post device is provided which comprises telescoping upright sections which are retracted when not in use into a casing disposed below ground level with a hinged top cover flush with the surface of the playing field. The top cover can be raised to permit raising and lowering of the goal post but is lowered at other times so as to not interfere with the play on the field. A hydraulic activating device is provided for raising and lowering the goal post and the top cover of the casing. Artificial turf is provided to cover the top cover portion of the casing.