Abstract: An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.

Abstract: A device that can warm a hand of a user and/or patient to facilitate collection of blood samples (e.g., capillary blood sample collection) is described herein. The device provides controlled amounts of heat directed to the palm of a user and/or patient to facilitate collection of high-quality capillary blood samples. The device is designed in such a way to provide a comfortable resting position for the hand that allows heating the hand of the user and/or patient while simultaneously providing access to the finger of the user and/or patient to carry out one or more steps in preparation for collection of capillary blood samples from the finger. The device will also monitor the temperature to limit the max temperature to a safe level, control the palm temperature to a desired level, and use a conductive material to enable rapid heating.

Abstract: A random access automated molecular testing system and method is used with a planar polymerase chain reaction (PCR) chip to provide molecular detection covering a wide variety of assays/tests in a small footprint. An automated transport mechanism moves the PCR chip between a pipette loading station, a sealing station and an amplification and detection module to provide batchless and random-access amplification and detection of a biological sample fluid. The PCR chip a planar rectangular body, a U-shaped channel for receiving sample fluid from an inlet port and a gripping feature laterally extending from an upper surface of the body above the inlet port for use by the automated transport mechanism. An amplification and detection module includes a heating block, a clip with a viewing window for retaining the PCR chip and a detection platform for identifying a content characteristic of interest of the sample fluid.

Abstract: An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.

Abstract: An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.

Abstract: An analyzer system for in vitro diagnostics includes a sample handler module having a robot arm that delivers samples from drawers into carriers on a linear synchronous motor automation track. Samples are delivered via the automation track to individual track sections associated with individual analyzer modules. Analyzer modules aspirate sample portions directly from the sample carriers and perform analysis thereon.

Abstract: A multi-view stereo approach generates an inventory of objects located on an object holder. An object may be a sample tube and an object holder may be a tube rack as used in lab automation for healthcare diagnostics. A processor performs 3D tracking of the object holder and the geometric analysis of multiple images generated by a calibrated camera. A homography mapping between images is utilized to warp a second image to a viewpoint of a first image. Plane induced parallax causes a normalized cross-correlation score between the first image and the warped second image of a location on the holder that has an object that is significantly different from a normalized cross-correlation score of a location that has not an object and enables the processor to infer tube inventory and absence or presence of a tube at a location in a rack.

Abstract: Disclosed are methods adapted to calibrate a robot gripper to a camera. The method includes providing a robot with a coupled moveable gripper, providing one or more cameras, providing a target scene having one or more fixed target points, moving the gripper and capturing images of the target scene at two or more imaging locations, recording positions in the gripper coordinate system for each of the imaging locations, recording images in a camera coordinate system, and processing the images and positions to determine a gripper-to-camera transformation between the gripper coordinate system and the camera coordinate system. The transformation may be accomplished by nonlinear least-squares minimization, such as the Levenberg-Marquardt method. Robot calibration apparatus for carrying out the method are disclosed, as are other aspects.

Abstract: A multi-view stereo approach generates an inventory of objects located on an object holder. An object may be a sample tube and an object holder may be a tube rack as used in lab automation for healthcare diagnostics. A processor performs 3D tracking of the object holder and the geo-metric analysis of multiple images generated by a calibrated camera. A homography mapping between images is utilized to warp a second image to a viewpoint of a first image. Plane induced parallax causes a normalized cross-correlation score between the first image and the warped second image of a location on the holder that has an object that is significantly different from a normalized cross-correlation score of a location that has not an object and enables the processor to infer tube inventory and absence or presence of a tube at a location in a rack.

Abstract: A method of scheduling an operation and a method of salvaging a launched test on a sample analyzer having a plurality of system resources for which there is a discrete, redundant subsystem Methods include scheduling real-time actions for execution on the subsystem or its redundant subsystem, linking the subsystem or a first redundant subsystem to another subsystem or to a second redundant subsystem, commanding the subsystem or the redundant subsystem to execute the actions for execution, executing each of the actions, monitoring execution of the actions, and re-scheduling an action for execution on a first subsystem on a corresponding discrete, redundant subsystem when an error or malfunction has occurred that may impact the launched test If re-scheduling is not possible, then the method includes trying to pause the launched test When pausing fails, the method includes marking the test bad an removing the test with minimal interference.

Abstract: Disclosed is an apparatus for automated synthesis containing a shaker deck with a plurality of reaction blocks containing a plurality of reaction wells, an arm containing an array of extending units capable of actuating physical steps along a plurality of axes of each reaction block, each reaction block being situated on a turntable, each turntable being further capable of rotating the reaction block along a central axis. Also disclosed are methods of preparing a peptide, oligonucleotide an small molecules using the apparatus.