Abstract: Provided is a new disintegrin polypeptide, methods of making such polypeptides, and methods of using them to treat disintegrin-associated disorders and conditions and to identify agents that modulate Metalloproteinase-Disintegrin polypeptide activities.

Abstract: There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1? and for a substrate comprising: R1-Asp-R2-R3 wherein R1 and R3 are independently any D or L isomer amino acid, R2 is Ala or Gly, and wherein the specific protease cleavage site is between Asp and R2. Inhibitor compounds, compositions and methods for inhibiting Interleukin 1? protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp.

Abstract: The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration, and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.

Abstract: A method and device for illuminating a lighting element include an input for receiving an electrical signal from a separate mobile device, a lighting element, a memory for storing a plurality of user-selectable lighting modes, and a processor. The processor illuminates the lighting elements according to both the selected lighting mode and the electrical signal received from the separate device. The separate device may be a digital audio player, and the processor may vary the intensity of mode-specific lighting according to the signal from the audio player. Further, the selected mode may cause a strobe or text message to be displayed when another signal indicates that a page or email has been received. The lighting element may be an LED, an array of them, or a display screen with pixel lighting elements.