Patents by Inventor Roy Cleeland

Roy Cleeland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorogenic materials and labeling techniques
    Patent number: 4238589
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: December 9, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Radiolabelled rubella virus and method
    Patent number: 4178360
    Abstract: A novel labelled antigen consisting of .sup.125 I-rubella virus and its use in a radioimmunoassay for rubella virus specific antibodies in human serum is disclosed.
    Type: Grant
    Filed: March 15, 1978
    Date of Patent: December 11, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Joanne Durkin, Michael J. Kramer
  • 1-Dimethylamino-2,4-diphenyl-1-butene-3,4-dione
    Patent number: 4045487
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: August 30, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Certain 2-hydroxy-2,4-diaryl-3-furanones
    Patent number: 4038289
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl: R.sub.2 is phenyl or substituted phenyl: and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: July 26, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Fluorogenic materials and labeling techniques
    Patent number: 4018884
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl or phenyl lower alkyl: R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: April 19, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele
  • Diagnostic test for opium alkaloids
    Patent number: 3972992
    Abstract: Amino lower alkyl ethers of the phenolic hydroxyl group of opium alkaloids are linked via a peptide linkage to carboxylated latex polymers to form reagents which are useful in a sensitive diagnostic test to detect the presence of opium alkaloids in body fluids.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: August 3, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Hans Jacob Hager
  • Fluorogenic 2-oxy-3(2H)-furanone materials
    Patent number: 3969373
    Abstract: Compounds of the formula ##SPC1##Wherein R.sub.1 is lower alkyl or phenyl lower alkyl; R.sub.2 is phenyl or substituted phenyl; and R.sub.3 is substituted or unsubstituted phenyl, naphthyl or indolyl;Are fluorogenic reagents which react with primary amino groups to form fluorophors. The above compounds are useful for fluorescent labeling of materials of biological importance.
    Type: Grant
    Filed: June 26, 1975
    Date of Patent: July 13, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roy Cleeland, Jr., Emanuel Grunberg, Willy Leimgruber, Manfred Weigele