Abstract: Apparatus and methods are described including an additional lens (24) made from an amorphous viscoelastic material and having an optical design. A curvature of the additional lens (24) is changed such as to conform with a curvature of abase eyeglasses lens (22), without causing a loss of the optical design of the additional lens (24), by heating the additional lens (24) to a temperature at which a Tan Delta of the amorphous viscoelastic material is between 0.2 and 0.8, and shaping the additional lens (24). Subsequently, the additional lens (24) is adhered to the base eyeglasses lens (22). The optical design of the additional lens (24) is such that, upon being adhered to the base eyeglasses lens (22), the adhered base eyeglasses lens (22) and the additional lens (24) provide a combined lens (20) having a desired optical prescription. Other applications are also described.

Abstract: A coupled enzyme reaction point of care lateral assay system detects and measures an active enzyme biomarker from a patient's blood sample. The lateral assay system has a point of care blood collector for collecting blood into a blood collection vial. A biomarker detection mechanism has at least three lateral flow strips. Each lateral flow strip has a fluid input zone, a corresponding reaction zone and a pretreatment band. The fluid flow strips include a test strip for separation of cells from the patient's blood sample. The reaction zones include components from a multiplicity of substrates, cofactors, buffers and cryoprotectants, and a multiplicity of tethered enzymes. At least one of the tethered enzymes is an enzyme that produces luminescence. The tethered enzymes are adapted to react to a constituent such as a biomarker. A photonic luminescence reader measures light emitted from an active enzyme biomarker present in the patient's blood.

Abstract: Systems and methods for assessing mental health of a person, including: recording digital activity data of the user on the mobile device, wherein the digital activity data does not include personal content of the user, applying the digital activity data to a plurality of machine learning models, wherein each of the machine learning models represents a digital phenotype for a different mental health condition, determining a similarity score for each mental health condition corresponding to each of the plurality of machine learning models based on comparing an output of the respective machine learning model to a digital phenotype for the corresponding mental health condition, outputting, at a user's display, the at least one mental health similarity score, and predicting, by the processor, at least one mental health condition of the user based on the calculated similarity scores.

Abstract: The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.

Abstract: A coupled enzyme reaction assay to measure the activity of a first enzyme in a sample taken from a patient. The reaction assay includes a test well which includes a freeze-dried mixture having two layers where the first layer includes first tethered enzyme nanobots, where each nanobot has a nanoparticle tethered to a set of second enzymes. A second layer is introduced into the test well. The set of second enzymes are adapted to react with a substrate within the test well. The first layer of the freeze-dried mixture includes second tethered nanobots formed by tethering a nanoparticle to a set of third enzymes to provide oriented immobilization of the set of the third enzymes. The third enzymes react to produce a signal for determining the amount of enzymatic activity of the first enzyme in the sample from the patient.

Abstract: A coupled enzyme reaction point of care assay system detects and measures an active enzyme biomarker from a patient's blood sample. The assay system has a point of care blood collector for collecting blood into a blood collection vial. A biomarker detection mechanism has at least three fluid flow entities. Each fluid flow entity has a fluid input zone and a corresponding reaction zone. The fluid flow entities include a test strip, a negative control strip and a positive control strip. The reaction zones include components from a multiplicity of substrates, co-factors, buffers and cryoprotectants, and a multiplicity of tethered enzymes. At least one of the tethered enzymes is an enzyme that produces luminescence. The tethered enzymes are adapted to react to a constituent which may be a biomarker. A photonic luminescence reader measures light emitted from an active enzyme biomarker present in the patient's blood.

Abstract: The invention disclosed herein concerns an amperometric enzyme-based biosensor which exhibits high accuracy, high bioelectrocatalytic currents, linear response, low overpotentials and stability.

Abstract: The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.

Abstract: The present invention relates to a method of detecting a target at least partially single-stranded viral genome in a sample. Also disclosed are kits and reaction mixtures.

Abstract: A system for determining a fluid level includes a front end and a measurement probe. The measurement probe receives a pulse from the front end and returns a partially reflected pulse and a fully reflected pulse to the front end. The partially reflected pulse is evaluated to determine a liquid level within a tank that includes the measurement probe. The measurement probe includes a conductive trace configuration to provide a time delay to prevent pulse build up.

Abstract: Apparatus and methods are described including an additional lens (24) made from an amorphous viscoelastic material and having an optical design. A curvature of the additional lens (24) is changed such as to conform with a curvature of abase eyeglasses lens (22), without causing a loss of the optical design of the additional lens (24), by heating the additional lens (24) to a temperature at which a Tan Delta of the amorphous viscoelastic material is between 0.2 and 0.8, and shaping the additional lens (24). Subsequently, the additional lens (24) is adhered to the base eyeglasses lens (22). The optical design of the additional lens (24) is such that, upon being adhered to the base eyeglasses lens (22), the adhered base eyeglasses lens (22) and the additional lens (24) provide a combined lens (20) having a desired optical prescription. Other applications are also described.

Abstract: Systems and methods for assessing mental health of a person, including: recording digital activity data of the user on the mobile device, wherein the digital activity data does not include personal content of the user, applying the digital activity data to a plurality of machine learning models, wherein each of the machine learning models represents a digital phenotype for a different mental health condition, determining a similarity score for each mental health condition corresponding to each of the plurality of machine learning models based on comparing an output of the respective machine learning model to a digital phenotype for the corresponding mental health condition, outputting, at a user's display, the at least one mental health similarity score, and predicting, by the processor, at least one mental health condition of the user based on the calculated similarity scores.

Abstract: Apparatus and methods are described including adhering a first lens to a second lens such as to form a combined lens having a given optical design, by placing the first lens and the second lens in respective first and second pressure chambers with an adhesive layer disposed between the first lens and the second lens, bringing a convex surface of the first lens into contact with the adhesive layer, and bringing a concave surface of the second lens into contact with the adhesive layer. Other applications are also described.

Abstract: The present invention relates to methods of detecting a neural injury biomarker in a biological sample. The method includes subjecting a biological sample to an assay according to the present invention that produces a measurable signal and detecting the measurable signal. The presence or absence of the measurable signal indicates the presence or absence of the biomarker in the sample. The present invention also relates to methods of determining the state of a subject's neural injury. The present invention also relates to systems and devices useful in carrying out the methods of the present invention.

Abstract: The present application relates to methods of detecting a target nucleic acid molecule in a sample. The method includes providing a sample containing a target nucleic acid molecule and a capture oligonucleotide molecule. In one embodiment, the capture oligonucleotide molecule has (i) a length of 30-60 base pairs, (ii) a 4-8 base pair overhang on its 3? end, (iii) a 5? tail, (iv) a target-specific portion between the 3? end and the 5? tail, (v) a deoxy-adenosine diphosphate content of 40-50%, (vi) no deoxy thymidine phosphate in the 3? end or the 5? tail, and (vii) the 3? end and the 5? tail having an ATP content which is 40-50% of that of the capture oligonucleotide molecule. In another aspect of the method of detecting, certain reagents are coupled to a solid support. The present application also relates to compositions and kits useful in carrying out the methods of the present application.